| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pralsetinib perturbation in NCI-H1792 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pralsetinib_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.245029 |
| CD44 | CD44 molecule (Indian blood group) | 0.10883 |
| SMAD3 | SMAD family member 3 | 0.0935009 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0899137 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0892864 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0846342 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0759581 |
| DST | dystonin | 0.0752417 |
| PCBP2 | poly(rC) binding protein 2 | 0.0688607 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.066131 |
| NTN4 | netrin 4 | 0.0656411 |
| MYO10 | myosin X | 0.0635956 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0608245 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0573322 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0562215 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0562118 |
| ANGPTL4 | angiopoietin-like 4 | 0.0544994 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0541594 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0540265 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0527151 |
| ASPH | aspartate beta-hydroxylase | 0.051801 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0508502 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0508098 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0494908 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0487025 |
| LOX | lysyl oxidase | 0.048124 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0466563 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0463619 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0451339 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0437531 |
| RAD51B | RAD51 paralog B | 0.0426333 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0422156 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0407881 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0397266 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0395769 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0390897 |
| ECE1 | endothelin converting enzyme 1 | 0.038901 |
| APP | amyloid beta (A4) precursor protein | 0.0385887 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.038113 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0380318 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0376477 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0374847 |
| MAP1B | microtubule-associated protein 1B | 0.0374204 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0373548 |
| LDHA | lactate dehydrogenase A | 0.0372909 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | 0.0367372 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0365988 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0365817 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0364403 |
| IFI44L | interferon-induced protein 44-like | 0.0364048 |
| FAM107B | family with sequence similarity 107, member B | 0.0360105 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0358269 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.035821 |
| CA12 | carbonic anhydrase XII | 0.0352257 |
| EHBP1 | EH domain binding protein 1 | 0.0352067 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0351931 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0348194 |
| LOXL2 | lysyl oxidase-like 2 | 0.0347686 |
| SIK3 | SIK family kinase 3 | 0.0343963 |
| ENO1 | enolase 1, (alpha) | 0.033724 |
| RUNX1 | runt-related transcription factor 1 | 0.0333021 |
| ADAMTS14 | ADAM metallopeptidase with thrombospondin type 1 motif, 14 | 0.0330781 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0327267 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0326878 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0324084 |
| B2M | beta-2-microglobulin | 0.0322345 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0318741 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0317987 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0312792 |
| NAV2 | neuron navigator 2 | 0.0308163 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0307817 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0307672 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0304438 |
| KSR1 | kinase suppressor of ras 1 | 0.0303866 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0299444 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | 0.0293064 |
| KIAA1217 | KIAA1217 | 0.029189 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0289051 |
| IL1R1 | interleukin 1 receptor, type I | 0.0285664 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0283256 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0283123 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.0282783 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0267179 |
| RPL4 | ribosomal protein L4 | 0.0266211 |
| SYNJ2 | synaptojanin 2 | 0.0263899 |
| CDK6 | cyclin-dependent kinase 6 | 0.0263107 |
| CANX | calnexin | 0.0258202 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0256257 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0255933 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.02557 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | 0.025506 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0253742 |
| NRP1 | neuropilin 1 | 0.0253427 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.0251813 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0249771 |
| CORO1C | coronin, actin binding protein, 1C | 0.0249724 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0249683 |
| ZNF638 | zinc finger protein 638 | 0.024831 |
| VEGFA | vascular endothelial growth factor A | 0.0246638 |
| TNNC1 | troponin C type 1 (slow) | 0.024612 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.152803 |
| TMSB10 | thymosin beta 10 | -0.125836 |
| FTL | ferritin, light polypeptide | -0.116769 |
| CDH13 | cadherin 13 | -0.0846418 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.074561 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0716033 |
| RPL35A | ribosomal protein L35a | -0.0691084 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0688935 |
| NRG1 | neuregulin 1 | -0.063313 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0619175 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.055003 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0515801 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0512037 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0505705 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0496733 |
| RPL37A | ribosomal protein L37a | -0.0493394 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0473297 |
| RPS29 | ribosomal protein S29 | -0.0444011 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.0436253 |
| RBM39 | RNA binding motif protein 39 | -0.0431524 |
| RPL31 | ribosomal protein L31 | -0.0426737 |
| RPLP1 | ribosomal protein, large, P1 | -0.0421667 |
| RPS25 | ribosomal protein S25 | -0.0416617 |
| DNER | delta/notch-like EGF repeat containing | -0.0414322 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0409219 |
| PID1 | phosphotyrosine interaction domain containing 1 | -0.0409199 |
| RPS8 | ribosomal protein S8 | -0.0404365 |
| RPLP2 | ribosomal protein, large, P2 | -0.0389344 |
| TMEM165 | transmembrane protein 165 | -0.0382786 |
| MTSS1 | metastasis suppressor 1 | -0.0375711 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0367858 |
| RPS11 | ribosomal protein S11 | -0.0355565 |
| RPL34 | ribosomal protein L34 | -0.0349735 |
| RPS24 | ribosomal protein S24 | -0.0349417 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0344569 |
| RPS19 | ribosomal protein S19 | -0.0342605 |
| RPS13 | ribosomal protein S13 | -0.0340095 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0338193 |
| PTMA | prothymosin, alpha | -0.0336402 |
| RPL11 | ribosomal protein L11 | -0.0331061 |
| STC1 | stanniocalcin 1 | -0.0326095 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0324553 |
| RPL9 | ribosomal protein L9 | -0.0321672 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0320891 |
| RPL28 | ribosomal protein L28 | -0.0318844 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0316719 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0307354 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0306914 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0306327 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0298012 |
| RPL7A | ribosomal protein L7a | -0.0297334 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0294228 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0291376 |
| RPS23 | ribosomal protein S23 | -0.0285639 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0277026 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0274643 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0273688 |
| RPL32 | ribosomal protein L32 | -0.0272128 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0270782 |
| RPS5 | ribosomal protein S5 | -0.0270566 |
| OXR1 | oxidation resistance 1 | -0.0264765 |
| TMEM263 | transmembrane protein 263 | -0.0259241 |
| RPL38 | ribosomal protein L38 | -0.0259238 |
| RPL36 | ribosomal protein L36 | -0.0259158 |
| IER3 | immediate early response 3 | -0.0257665 |
| VIM | vimentin | -0.0254862 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0251706 |
| LRRC8C | leucine rich repeat containing 8 family, member C | -0.0250522 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0250496 |
| TMTC1 | transmembrane and tetratricopeptide repeat containing 1 | -0.0247755 |
| HM13 | histocompatibility (minor) 13 | -0.0243467 |
| GNAS | GNAS complex locus | -0.0243017 |
| RPL12 | ribosomal protein L12 | -0.0241682 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0239174 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0238076 |
| PRRX1 | paired related homeobox 1 | -0.0235529 |
| HIP1 | huntingtin interacting protein 1 | -0.0235041 |
| RPS21 | ribosomal protein S21 | -0.023318 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0232397 |
| RPS16 | ribosomal protein S16 | -0.0231702 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0229671 |
| GNA12 | guanine nucleotide binding protein (G protein) alpha 12 | -0.0229294 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0225843 |
| RPL19 | ribosomal protein L19 | -0.0224008 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0222131 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0221404 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0221097 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0216568 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.021576 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | -0.0215493 |
| ATG7 | autophagy related 7 | -0.0213298 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0211212 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0210061 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0209777 |
| FAM20C | family with sequence similarity 20, member C | -0.0209223 |
| RPL26 | ribosomal protein L26 | -0.0207494 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0204957 |
| HMGA1 | high mobility group AT-hook 1 | -0.0204691 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0203068 |
| RPL23 | ribosomal protein L23 | -0.0201425 |
