| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pralsetinib perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pralsetinib_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | 0.155231 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.117398 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.103631 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.101669 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0899237 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0859245 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0858858 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0834705 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0820167 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.079907 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0723348 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0719152 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0710898 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0709861 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0688382 |
| FAM107B | family with sequence similarity 107, member B | 0.0651123 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0622614 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0611779 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0604278 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0582489 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0550362 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.053655 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0525405 |
| MSN | moesin | 0.0491437 |
| HLA-B | major histocompatibility complex, class I, B | 0.0490278 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0487764 |
| LDHA | lactate dehydrogenase A | 0.0480843 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0478274 |
| RUNX1 | runt-related transcription factor 1 | 0.0476368 |
| ATXN1 | ataxin 1 | 0.0467707 |
| PYGL | phosphorylase, glycogen, liver | 0.0460439 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.045796 |
| MYOF | myoferlin | 0.0455273 |
| RPS6 | ribosomal protein S6 | 0.0453969 |
| B2M | beta-2-microglobulin | 0.0453329 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.044225 |
| NDRG1 | N-myc downstream regulated 1 | 0.0436784 |
| MYO1E | myosin IE | 0.0426398 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.040486 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0403337 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.03808 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0380345 |
| GOLGA4 | golgin A4 | 0.0377664 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0372522 |
| HLA-A | major histocompatibility complex, class I, A | 0.0372485 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | 0.0363012 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0361444 |
| LAMC2 | laminin, gamma 2 | 0.0360571 |
| ANGPTL4 | angiopoietin-like 4 | 0.0354674 |
| GOLGB1 | golgin B1 | 0.0351798 |
| TPI1 | triosephosphate isomerase 1 | 0.0349107 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0345999 |
| C15ORF48 | chromosome 15 open reading frame 48 | 0.0345386 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0343232 |
| EGFR | epidermal growth factor receptor | 0.0338591 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0337607 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0332663 |
| CCL5 | chemokine (C-C motif) ligand 5 | 0.032961 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0327535 |
| RPLP0 | ribosomal protein, large, P0 | 0.0323753 |
| PDE10A | phosphodiesterase 10A | 0.0319128 |
| MED13 | mediator complex subunit 13 | 0.0316436 |
| MORF4L2 | mortality factor 4 like 2 | 0.0312601 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.03122 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0311845 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.031046 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0306998 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0305091 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0301947 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0301683 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0295554 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0294449 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.028031 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0280001 |
| EFNA1 | ephrin-A1 | 0.027811 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0277986 |
| FMNL2 | formin-like 2 | 0.027732 |
| STC2 | stanniocalcin 2 | 0.0273422 |
| COPA | coatomer protein complex, subunit alpha | 0.0271715 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.027041 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0269769 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.0266428 |
| IL6 | interleukin 6 | 0.0265085 |
| BZW2 | basic leucine zipper and W2 domains 2 | 0.0262242 |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | 0.0260585 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0259539 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0254991 |
| CYTH1 | cytohesin 1 | 0.025443 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0253533 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.025198 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0249024 |
| PRRC2C | proline-rich coiled-coil 2C | 0.024874 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0248078 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | 0.0247802 |
| PSEN1 | presenilin 1 | 0.0245064 |
| RPS12 | ribosomal protein S12 | 0.0244625 |
| INTS6 | integrator complex subunit 6 | 0.0242671 |
| NF1 | neurofibromin 1 | 0.0240722 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0239475 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0239071 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | -0.227549 |
| GRAMD1B | GRAM domain containing 1B | -0.20333 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.117037 |
| TMSB10 | thymosin beta 10 | -0.103749 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0933055 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0733301 |
| FGB | fibrinogen beta chain | -0.07175 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.069744 |
| RTN4 | reticulon 4 | -0.0692366 |
| RPS27A | ribosomal protein S27a | -0.0674443 |
| IGF2 | insulin-like growth factor 2 | -0.0674362 |
| BICC1 | BicC family RNA binding protein 1 | -0.0664612 |
| HDAC9 | histone deacetylase 9 | -0.063665 |
| FTL | ferritin, light polypeptide | -0.0624127 |
| RPL23 | ribosomal protein L23 | -0.0622925 |
| WDR43 | WD repeat domain 43 | -0.0594088 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0578859 |
| ERBIN | erbb2 interacting protein | -0.0567661 |
| LANCL1 | LanC lantibiotic synthetase component C-like 1 (bacterial) | -0.0547282 |
| NRG1 | neuregulin 1 | -0.0541872 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0504304 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0502441 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0488743 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0481395 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0465343 |
| PKM | pyruvate kinase, muscle | -0.0462269 |
| UBC | ubiquitin C | -0.0450136 |
| ECT2 | epithelial cell transforming 2 | -0.0446316 |
| YBX3 | Y box binding protein 3 | -0.0445307 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.0438234 |
| RHEB | Ras homolog enriched in brain | -0.0432477 |
| USP3 | ubiquitin specific peptidase 3 | -0.0431195 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0422442 |
| MKI67 | marker of proliferation Ki-67 | -0.0420705 |
| PTMA | prothymosin, alpha | -0.0415759 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0408079 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | -0.0401335 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0399392 |
| THBS1 | thrombospondin 1 | -0.0399099 |
| ANLN | anillin, actin binding protein | -0.0397887 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0387262 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0386852 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0383592 |
| PAWR | PRKC, apoptosis, WT1, regulator | -0.0379525 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.03787 |
| CYRIB | CYFIP related Rac1 interactor B | -0.0361173 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0346075 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0345235 |
| RFWD3 | ring finger and WD repeat domain 3 | -0.0344458 |
| YBX1 | Y box binding protein 1 | -0.033821 |
| KHDC4 | KH domain containing 4, pre-mRNA splicing factor | -0.0331708 |
| KLF6 | Kruppel-like factor 6 | -0.0328168 |
| PLEKHB2 | pleckstrin homology domain containing, family B (evectins) member 2 | -0.0326897 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0323639 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | -0.0323106 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0321334 |
| CHN1 | chimerin 1 | -0.0310612 |
| FGG | fibrinogen gamma chain | -0.0306576 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | -0.0304564 |
| TNPO1 | transportin 1 | -0.0303078 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0303027 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0302517 |
| ACACA | acetyl-CoA carboxylase alpha | -0.030225 |
| CENPF | centromere protein F, 350/400kDa | -0.0302083 |
| MORF4L1 | mortality factor 4 like 1 | -0.0298377 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -0.0297192 |
| EFNA5 | ephrin-A5 | -0.0296389 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0294275 |
| LAMB1 | laminin, beta 1 | -0.0293084 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | -0.0287433 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | -0.0287222 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -0.0287165 |
| SRGN | serglycin | -0.0284195 |
| RPS21 | ribosomal protein S21 | -0.0282645 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -0.028259 |
| RASAL2 | RAS protein activator like 2 | -0.028215 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0279962 |
| TPX2 | TPX2, microtubule-associated | -0.0278435 |
| TMEM123 | transmembrane protein 123 | -0.0276423 |
| AHR | aryl hydrocarbon receptor | -0.0270384 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0269453 |
| RPS29 | ribosomal protein S29 | -0.0268173 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0263383 |
| RHOA | ras homolog family member A | -0.0262774 |
| ZNF292 | zinc finger protein 292 | -0.0258577 |
| NEGR1 | neuronal growth regulator 1 | -0.0257846 |
| WTAP | Wilms tumor 1 associated protein | -0.0257288 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0257133 |
| AHNAK | AHNAK nucleoprotein | -0.0256103 |
| AK1 | adenylate kinase 1 | -0.0255245 |
| ZNF804A | zinc finger protein 804A | -0.0253859 |
| TPD52 | tumor protein D52 | -0.0251774 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0250264 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0248842 |
| NUSAP1 | nucleolar and spindle associated protein 1 | -0.0247671 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0245553 |
| ZFAND6 | zinc finger, AN1-type domain 6 | -0.0243451 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0242742 |
| VMP1 | vacuole membrane protein 1 | -0.0241217 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0239904 |
