| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pralsetinib perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Pralsetinib_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.187466 |
| MYOF | myoferlin | 0.107619 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0963514 |
| FN1 | fibronectin 1 | 0.088749 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0767611 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0731354 |
| FAM13A | family with sequence similarity 13, member A | 0.0730668 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0724188 |
| WDR26 | WD repeat domain 26 | 0.0717766 |
| HELZ | helicase with zinc finger | 0.0716384 |
| FUT11 | fucosyltransferase 11 (alpha (1,3) fucosyltransferase) | 0.0694599 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0683899 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0674299 |
| PTMA | prothymosin, alpha | 0.0635265 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0631092 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0611701 |
| WDR45B | WD repeat domain 45B | 0.0602107 |
| CERS6 | ceramide synthase 6 | 0.0595757 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0592078 |
| GOLGA4 | golgin A4 | 0.0574103 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0546606 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0544983 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | 0.0539663 |
| FMNL2 | formin-like 2 | 0.0533569 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.052715 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | 0.0525689 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0524197 |
| RUNX1 | runt-related transcription factor 1 | 0.0520892 |
| HMGA2 | high mobility group AT-hook 2 | 0.051457 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.0512687 |
| LAMC2 | laminin, gamma 2 | 0.0511643 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0503403 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0500341 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0488255 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0488136 |
| IRS2 | insulin receptor substrate 2 | 0.0480036 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0476545 |
| CCDC186 | coiled-coil domain containing 186 | 0.047593 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0471908 |
| ZNF207 | zinc finger protein 207 | 0.0464154 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0464074 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0460849 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0459223 |
| MCTP2 | multiple C2 domains, transmembrane 2 | 0.0458508 |
| RPS12 | ribosomal protein S12 | 0.0457125 |
| PKM | pyruvate kinase, muscle | 0.0449723 |
| CDC73 | cell division cycle 73 | 0.0441466 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0438197 |
| GRHL1 | grainyhead-like 1 (Drosophila) | 0.0432994 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0431147 |
| INTS6 | integrator complex subunit 6 | 0.0429253 |
| CDK13 | cyclin-dependent kinase 13 | 0.0424739 |
| ADNP | activity-dependent neuroprotector homeobox | 0.0422711 |
| AFDN | afadin, adherens junction formation factor | 0.0422529 |
| UHMK1 | U2AF homology motif (UHM) kinase 1 | 0.0420614 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0418682 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0413655 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0413072 |
| FBXL13 | F-box and leucine-rich repeat protein 13 | 0.0412959 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0412623 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0411871 |
| ADM | adrenomedullin | 0.0408221 |
| CLTC | clathrin, heavy chain (Hc) | 0.0401808 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0400022 |
| FLNB | filamin B, beta | 0.0399513 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0396326 |
| ENO1 | enolase 1, (alpha) | 0.0395901 |
| PKP4 | plakophilin 4 | 0.0393516 |
| NLGN1 | neuroligin 1 | 0.0389872 |
| ITSN2 | intersectin 2 | 0.0387883 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0383359 |
| PIBF1 | progesterone immunomodulatory binding factor 1 | 0.0382015 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0381883 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0379363 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0375294 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0374726 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0374531 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.0372567 |
| MYO1E | myosin IE | 0.0371425 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0370356 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0369881 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0369449 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.0369433 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.03691 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | 0.0368055 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0367025 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0365733 |
| TXNIP | thioredoxin interacting protein | 0.0363878 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0360603 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0358235 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0357252 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0354321 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0347671 |
| SRP54 | signal recognition particle 54kDa | 0.0346624 |
| COG5 | component of oligomeric golgi complex 5 | 0.0345565 |
| MON2 | MON2 homolog (S. cerevisiae) | 0.0345425 |
| CANX | calnexin | 0.0344349 |
| SETD5 | SET domain containing 5 | 0.0343506 |
| SEC24A | SEC24 family member A | 0.0342386 |
| PRELID2 | PRELI domain containing 2 | 0.034083 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MUC16 | mucin 16, cell surface associated | -0.120574 |
| ERBIN | erbb2 interacting protein | -0.111966 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.100861 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0958291 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0938587 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0826554 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0766052 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0757 |
| JMJD1C | jumonji domain containing 1C | -0.0733055 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0731593 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | -0.0706694 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0700197 |
| MT2A | metallothionein 2A | -0.0694816 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0685905 |
| IGF2 | insulin-like growth factor 2 | -0.0680292 |
| EGFR | epidermal growth factor receptor | -0.0660445 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0632688 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0618202 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0609829 |
| RPL37 | ribosomal protein L37 | -0.0600558 |
| GRB10 | growth factor receptor-bound protein 10 | -0.059933 |
| TXNRD1 | thioredoxin reductase 1 | -0.058412 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0583156 |
| RPLP1 | ribosomal protein, large, P1 | -0.0582331 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | -0.0563273 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.056322 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0562036 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0561869 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0537809 |
| TACC2 | transforming, acidic coiled-coil containing protein 2 | -0.0532473 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0523717 |
| NF1 | neurofibromin 1 | -0.0517695 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.051465 |
| SMOC1 | SPARC related modular calcium binding 1 | -0.0513152 |
| CLDN4 | claudin 4 | -0.0504163 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.050159 |
| SQSTM1 | sequestosome 1 | -0.0484978 |
| GPC6 | glypican 6 | -0.0477173 |
| ACTG1 | actin gamma 1 | -0.0474263 |
| AK1 | adenylate kinase 1 | -0.0471329 |
| MYO5B | myosin VB | -0.0466737 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.0465031 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.045716 |
| RPS29 | ribosomal protein S29 | -0.0455162 |
| ABLIM1 | actin binding LIM protein 1 | -0.0454634 |
| KRT17 | keratin 17, type I | -0.045391 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0453324 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | -0.0451827 |
| OSBPL10 | oxysterol binding protein-like 10 | -0.0448175 |
| ATXN1 | ataxin 1 | -0.044775 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0440689 |
| MED13L | mediator complex subunit 13-like | -0.0431067 |
| RPS16 | ribosomal protein S16 | -0.0428833 |
| STC1 | stanniocalcin 1 | -0.0426853 |
| DYM | dymeclin | -0.0426236 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | -0.0423774 |
| RPL35A | ribosomal protein L35a | -0.0418086 |
| NEK7 | NIMA-related kinase 7 | -0.0416783 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0415363 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0414764 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0414619 |
| CDK19 | cyclin-dependent kinase 19 | -0.0411497 |
| ITGB4 | integrin, beta 4 | -0.0409472 |
| FBXO11 | F-box protein 11 | -0.0402822 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0397664 |
| ACTN4 | actinin, alpha 4 | -0.0397291 |
| RNF213 | ring finger protein 213 | -0.0395143 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0393949 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.0392618 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0391323 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | -0.0388301 |
| TJP2 | tight junction protein 2 | -0.0387671 |
| SBF2 | SET binding factor 2 | -0.0384105 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0382627 |
| NAV2 | neuron navigator 2 | -0.0371421 |
| MXD1 | MAX dimerization protein 1 | -0.0370802 |
| SRPK2 | SRSF protein kinase 2 | -0.0368093 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0365952 |
| RPL11 | ribosomal protein L11 | -0.0363899 |
| CFDP1 | craniofacial development protein 1 | -0.0363238 |
| TBCA | tubulin folding cofactor A | -0.0360497 |
| DSPP | dentin sialophosphoprotein | -0.0357714 |
| ADAM10 | ADAM metallopeptidase domain 10 | -0.0353376 |
| FNIP1 | folliculin interacting protein 1 | -0.0351194 |
| NBEAL1 | neurobeachin-like 1 | -0.0348911 |
| SEPTIN2 | septin 2 | -0.0348115 |
| RAB8B | RAB8B, member RAS oncogene family | -0.0346676 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0344484 |
| SLC12A6 | solute carrier family 12 (potassium/chloride transporter), member 6 | -0.0339452 |
| TOP1 | topoisomerase (DNA) I | -0.0337563 |
| OSMR | oncostatin M receptor | -0.0335935 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0334274 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0333369 |
| NHSL1 | NHS-like 1 | -0.0332509 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0332461 |
| TMSB10 | thymosin beta 10 | -0.0331611 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.033126 |
| SOS2 | son of sevenless homolog 2 (Drosophila) | -0.0330241 |
| PFKP | phosphofructokinase, platelet | -0.032829 |
| S100A10 | S100 calcium binding protein A10 | -0.0326318 |
