| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pralsetinib perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pralsetinib_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.265367 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.251241 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0786696 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0733512 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0679594 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0619006 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0600911 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0593656 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.058663 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0585121 |
| ENO1 | enolase 1, (alpha) | 0.0578569 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0562355 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0557503 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0555056 |
| TPM3 | tropomyosin 3 | 0.0537349 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0535052 |
| RPS12 | ribosomal protein S12 | 0.0490449 |
| GOLGB1 | golgin B1 | 0.0484127 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.048206 |
| TXNRD1 | thioredoxin reductase 1 | 0.0480075 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0464592 |
| CANX | calnexin | 0.0459721 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0455615 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0452102 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0452013 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.045081 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0450492 |
| HOMER1 | homer scaffolding protein 1 | 0.0435785 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0434531 |
| INTS6 | integrator complex subunit 6 | 0.0422774 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0419705 |
| ASPH | aspartate beta-hydroxylase | 0.0416285 |
| DST | dystonin | 0.0415959 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0406626 |
| MSN | moesin | 0.0400986 |
| SET | SET nuclear proto-oncogene | 0.0396454 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0394151 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0393249 |
| RPL4 | ribosomal protein L4 | 0.0391219 |
| IPO7 | importin 7 | 0.0378219 |
| DSPP | dentin sialophosphoprotein | 0.0364148 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0362293 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0354714 |
| TPI1 | triosephosphate isomerase 1 | 0.0352442 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0347196 |
| RPS3 | ribosomal protein S3 | 0.0343839 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0342671 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0323082 |
| RPL3 | ribosomal protein L3 | 0.0319832 |
| JMJD1C | jumonji domain containing 1C | 0.0311783 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0311255 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0307867 |
| CLTC | clathrin, heavy chain (Hc) | 0.030471 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0294458 |
| PCBP2 | poly(rC) binding protein 2 | 0.0291181 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0290725 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0287688 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0287149 |
| RPLP0 | ribosomal protein, large, P0 | 0.0281485 |
| REL | v-rel avian reticuloendotheliosis viral oncogene homolog | 0.0279566 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0276896 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | 0.0271261 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0270263 |
| TLN1 | talin 1 | 0.026887 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.0265669 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0264635 |
| SPAG9 | sperm associated antigen 9 | 0.026432 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0263242 |
| PTMA | prothymosin, alpha | 0.025824 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0253845 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0252075 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0251846 |
| WNT2B | wingless-type MMTV integration site family, member 2B | 0.0250257 |
| C6ORF62 | chromosome 6 open reading frame 62 | 0.0248342 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.0243432 |
| GDI2 | GDP dissociation inhibitor 2 | 0.0241045 |
| RACK1 | receptor for activated C kinase 1 | 0.0241006 |
| ADAR | adenosine deaminase, RNA-specific | 0.024028 |
| RPS4X | ribosomal protein S4, X-linked | 0.0238711 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.0235931 |
| RPS18 | ribosomal protein S18 | 0.0235182 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0233553 |
| RPS7 | ribosomal protein S7 | 0.0229953 |
| KRT18 | keratin 18, type I | 0.0229927 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.022816 |
| BRD2 | bromodomain containing 2 | 0.0227953 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0224576 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0222726 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.022201 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.022093 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0220638 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0220503 |
| MCL1 | myeloid cell leukemia 1 | 0.0219287 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.021416 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0210094 |
| RPL14 | ribosomal protein L14 | 0.0207829 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0206582 |
| COPA | coatomer protein complex, subunit alpha | 0.0206023 |
| RPS17 | ribosomal protein S17 | 0.0205574 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0203225 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.30412 |
| TMSB10 | thymosin beta 10 | -0.0823567 |
| EGR1 | early growth response 1 | -0.0754188 |
| RAD51B | RAD51 paralog B | -0.0749825 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0653691 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0629425 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0548977 |
| PFN1 | profilin 1 | -0.0522469 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0506465 |
| OSMR | oncostatin M receptor | -0.0491645 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.046447 |
| GNAS | GNAS complex locus | -0.0452403 |
| BBX | bobby sox homolog (Drosophila) | -0.0442607 |
| RPS21 | ribosomal protein S21 | -0.0428637 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0425298 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0417901 |
| RYR3 | ryanodine receptor 3 | -0.0416912 |
| PDE10A | phosphodiesterase 10A | -0.0412503 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0399837 |
| IGF2 | insulin-like growth factor 2 | -0.0398174 |
| PTK2 | protein tyrosine kinase 2 | -0.0395493 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0372119 |
| PHIP | pleckstrin homology domain interacting protein | -0.0355423 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0353144 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0351657 |
| RPL35A | ribosomal protein L35a | -0.0349405 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0337539 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0335868 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.033443 |
| EXOC4 | exocyst complex component 4 | -0.0333802 |
| SBF2 | SET binding factor 2 | -0.0330314 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0326359 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0321903 |
| RSF1 | remodeling and spacing factor 1 | -0.0317596 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0317044 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0315502 |
| TMEM165 | transmembrane protein 165 | -0.0312672 |
| USP34 | ubiquitin specific peptidase 34 | -0.0310273 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0308113 |
| HLA-B | major histocompatibility complex, class I, B | -0.0307183 |
| ITSN1 | intersectin 1 (SH3 domain protein) | -0.0306329 |
| PHF21A | PHD finger protein 21A | -0.0305986 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0302329 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.030071 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0292477 |
| HMGA2 | high mobility group AT-hook 2 | -0.0285374 |
| CCDC91 | coiled-coil domain containing 91 | -0.0283668 |
| LATS2 | large tumor suppressor kinase 2 | -0.0282962 |
| ZNF292 | zinc finger protein 292 | -0.0269843 |
| NF1 | neurofibromin 1 | -0.0267908 |
| PCNX1 | pecanex 1 | -0.026728 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0260681 |
| TPM2 | tropomyosin 2 (beta) | -0.0260575 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0260305 |
| CCNL1 | cyclin L1 | -0.0258252 |
| DEK | DEK proto-oncogene | -0.0256498 |
| WDPCP | WD repeat containing planar cell polarity effector | -0.0256485 |
| DCUN1D4 | DCN1, defective in cullin neddylation 1, domain containing 4 | -0.0255321 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0250055 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0249838 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0246379 |
| RPS15 | ribosomal protein S15 | -0.0245369 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | -0.0243912 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0242055 |
| IGF2BP1 | insulin-like growth factor 2 mRNA binding protein 1 | -0.0240177 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0236266 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0236234 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.023254 |
| ATG7 | autophagy related 7 | -0.0230519 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0229296 |
| FMN1 | formin 1 | -0.0228586 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0226593 |
| YBX3 | Y box binding protein 3 | -0.0224749 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0223985 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0221723 |
| RBM25 | RNA binding motif protein 25 | -0.0219536 |
| UBE2K | ubiquitin-conjugating enzyme E2K | -0.0217282 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0215618 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0214817 |
| RPL23 | ribosomal protein L23 | -0.0212058 |
| RFX7 | regulatory factor X, 7 | -0.0207642 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0207317 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.020695 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0205273 |
| HMGA1 | high mobility group AT-hook 1 | -0.0204636 |
| KLHL5 | kelch-like family member 5 | -0.0204544 |
| MT1X | metallothionein 1X | -0.0204433 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0202962 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0202533 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0202219 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0198867 |
| NUP155 | nucleoporin 155kDa | -0.0197812 |
| CBX3 | chromobox homolog 3 | -0.0197202 |
| R3HDM1 | R3H domain containing 1 | -0.0194962 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0194622 |
| POTEF | POTE ankyrin domain family, member F | -0.0193013 |
| CEP192 | centrosomal protein 192kDa | -0.0190276 |
| TUBB | tubulin, beta class I | -0.0188992 |
| PFKP | phosphofructokinase, platelet | -0.0188566 |
| TAGLN2 | transgelin 2 | -0.0186487 |
