| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pralsetinib perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pralsetinib_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.255314 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.188593 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.160327 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.153725 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0983323 |
| DSPP | dentin sialophosphoprotein | 0.0926395 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0843184 |
| PTMA | prothymosin, alpha | 0.0823803 |
| ENO1 | enolase 1, (alpha) | 0.0805668 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0741115 |
| MSN | moesin | 0.0739686 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0730166 |
| FTL | ferritin, light polypeptide | 0.0721945 |
| CANX | calnexin | 0.0687871 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0607547 |
| VEGFA | vascular endothelial growth factor A | 0.0594103 |
| TMSB4X | thymosin beta 4, X-linked | 0.0587411 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0559142 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0555644 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0551594 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0547609 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0547587 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0545244 |
| GOLGB1 | golgin B1 | 0.0525748 |
| MCL1 | myeloid cell leukemia 1 | 0.0508667 |
| LAMB3 | laminin, beta 3 | 0.0502679 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0487695 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0482923 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0477732 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0475593 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0466001 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0454885 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0453806 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0445125 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.044393 |
| PCBP2 | poly(rC) binding protein 2 | 0.0443077 |
| DTNA | dystrobrevin, alpha | 0.0439115 |
| UBC | ubiquitin C | 0.043857 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.043226 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0432075 |
| TMF1 | TATA element modulatory factor 1 | 0.0419393 |
| TPM3 | tropomyosin 3 | 0.0415391 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0414939 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0414571 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0410568 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0409273 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0400834 |
| MYOF | myoferlin | 0.0399051 |
| SCFD1 | sec1 family domain containing 1 | 0.038759 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0385596 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0384367 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.0375718 |
| POTEF | POTE ankyrin domain family, member F | 0.0358071 |
| DST | dystonin | 0.0357011 |
| CD109 | CD109 molecule | 0.035307 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0351368 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0349505 |
| BRD2 | bromodomain containing 2 | 0.0348286 |
| LAMC2 | laminin, gamma 2 | 0.0346136 |
| CALR | calreticulin | 0.034104 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0330365 |
| MYO1E | myosin IE | 0.0330057 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0325274 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0325067 |
| MYO5B | myosin VB | 0.032474 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.0321372 |
| GOLGA4 | golgin A4 | 0.0316705 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0311084 |
| RAB10 | RAB10, member RAS oncogene family | 0.0306744 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.0304875 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.030427 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0303965 |
| HMGB2 | high mobility group box 2 | 0.0303804 |
| KIAA1217 | KIAA1217 | 0.0303559 |
| PCM1 | pericentriolar material 1 | 0.030205 |
| RPL3 | ribosomal protein L3 | 0.0300834 |
| LNPEP | leucyl/cystinyl aminopeptidase | 0.0299929 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0299542 |
| ANO6 | anoctamin 6 | 0.0290108 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0287287 |
| EZR | ezrin | 0.0283496 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0282643 |
| FHIT | fragile histidine triad | 0.028239 |
| CLTC | clathrin, heavy chain (Hc) | 0.0281915 |
| MORF4L2 | mortality factor 4 like 2 | 0.0281872 |
| CD44 | CD44 molecule (Indian blood group) | 0.0277558 |
| ARRDC3 | arrestin domain containing 3 | 0.0277506 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0276678 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0273523 |
| NAV2 | neuron navigator 2 | 0.027229 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0271662 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.027094 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0270862 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.0266314 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0265516 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0264609 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0262853 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0260528 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0258645 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.025606 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.103901 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0946295 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0636657 |
| RPL35A | ribosomal protein L35a | -0.0622583 |
| CCND1 | cyclin D1 | -0.0586726 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0564595 |
| LMO7 | LIM domain 7 | -0.0555289 |
| KRT7 | keratin 7, type II | -0.0549213 |
| RPL9 | ribosomal protein L9 | -0.048599 |
| RPL34 | ribosomal protein L34 | -0.0478203 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0434287 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0392173 |
| RPL11 | ribosomal protein L11 | -0.0389666 |
| RPS24 | ribosomal protein S24 | -0.0389296 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0385015 |
| CD2AP | CD2-associated protein | -0.0376748 |
| RPS25 | ribosomal protein S25 | -0.0376391 |
| TOP1 | topoisomerase (DNA) I | -0.0374986 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0372474 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0358314 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0355691 |
| RPL30 | ribosomal protein L30 | -0.0332757 |
| RPL19 | ribosomal protein L19 | -0.0329305 |
| TFG | TRK-fused gene | -0.032665 |
| RPL37A | ribosomal protein L37a | -0.032617 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0312978 |
| FAM3C | family with sequence similarity 3, member C | -0.0302558 |
| PLAU | plasminogen activator, urokinase | -0.030197 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0301284 |
| RPS13 | ribosomal protein S13 | -0.0300555 |
| ZFAND6 | zinc finger, AN1-type domain 6 | -0.0296869 |
| TMEM263 | transmembrane protein 263 | -0.0296809 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.029517 |
| GNAS | GNAS complex locus | -0.0287105 |
| TMSB10 | thymosin beta 10 | -0.0282536 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0270923 |
| RPS29 | ribosomal protein S29 | -0.0267557 |
| RPS3 | ribosomal protein S3 | -0.0265173 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | -0.0258296 |
| RPS23 | ribosomal protein S23 | -0.0252055 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0250521 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.0245837 |
| DEK | DEK proto-oncogene | -0.0243689 |
| ARF1 | ADP-ribosylation factor 1 | -0.02433 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0241437 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0238536 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | -0.023796 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0230255 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0227181 |
| RPS5 | ribosomal protein S5 | -0.0226266 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0224115 |
| CDC50A | cell division cycle 50 P4-ATPase accessory subunit A | -0.0223948 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | -0.0222027 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0220712 |
| ANXA2 | annexin A2 | -0.0213952 |
| TMEM123 | transmembrane protein 123 | -0.0211176 |
| RPL12 | ribosomal protein L12 | -0.0208716 |
| HMGA1 | high mobility group AT-hook 1 | -0.0208645 |
| TMEM165 | transmembrane protein 165 | -0.0208264 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0207639 |
| RPL26 | ribosomal protein L26 | -0.0202914 |
| PRRC1 | proline-rich coiled-coil 1 | -0.0202835 |
| NPC2 | Niemann-Pick disease, type C2 | -0.0199694 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0199041 |
| RPL31 | ribosomal protein L31 | -0.0196976 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0196558 |
| PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme | -0.0194271 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0191912 |
| SMG7 | SMG7 nonsense mediated mRNA decay factor | -0.0191879 |
| RPLP2 | ribosomal protein, large, P2 | -0.0191284 |
| RPL28 | ribosomal protein L28 | -0.0191231 |
| OSBPL3 | oxysterol binding protein-like 3 | -0.0190291 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.019005 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0189214 |
| MORF4L1 | mortality factor 4 like 1 | -0.0181566 |
| RPL23 | ribosomal protein L23 | -0.0181367 |
| DUSP5 | dual specificity phosphatase 5 | -0.0181065 |
| MSMO1 | methylsterol monooxygenase 1 | -0.0179922 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0178608 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0178441 |
| GNA13 | guanine nucleotide binding protein (G protein), alpha 13 | -0.0177943 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.017433 |
| OSMR | oncostatin M receptor | -0.0171665 |
| RPL6 | ribosomal protein L6 | -0.0168206 |
| RPS16 | ribosomal protein S16 | -0.0168021 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0167778 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | -0.0167481 |
| RPL7A | ribosomal protein L7a | -0.0167132 |
| RPL32 | ribosomal protein L32 | -0.0165427 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0164914 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | -0.0164263 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.0162236 |
| CD46 | CD46 molecule, complement regulatory protein | -0.0160621 |
| RAB1A | RAB1A, member RAS oncogene family | -0.015703 |
| RPL38 | ribosomal protein L38 | -0.0156895 |
| AREG | amphiregulin | -0.0154556 |
| ACTG1 | actin gamma 1 | -0.0151468 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.0151008 |
| CHMP2B | charged multivesicular body protein 2B | -0.0150458 |
| USP3 | ubiquitin specific peptidase 3 | -0.0150194 |
