| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pralsetinib perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Pralsetinib_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.236971 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.170166 |
| MYOF | myoferlin | 0.153315 |
| PM20D1 | peptidase M20 domain containing 1 | 0.117727 |
| DST | dystonin | 0.117423 |
| PDLIM5 | PDZ and LIM domain 5 | 0.111125 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.10072 |
| ENO1 | enolase 1, (alpha) | 0.0921895 |
| COL5A2 | collagen, type V, alpha 2 | 0.0901803 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0840653 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0814819 |
| LDHA | lactate dehydrogenase A | 0.0810998 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0804889 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0784666 |
| CD109 | CD109 molecule | 0.077376 |
| PDE10A | phosphodiesterase 10A | 0.0763686 |
| ASPH | aspartate beta-hydroxylase | 0.075041 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0705518 |
| CANX | calnexin | 0.0694723 |
| P3H2 | prolyl 3-hydroxylase 2 | 0.0663757 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0647541 |
| TXNRD1 | thioredoxin reductase 1 | 0.0643362 |
| RPLP0 | ribosomal protein, large, P0 | 0.0626838 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0623162 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.062305 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0616164 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0611876 |
| AGTPBP1 | ATP/GTP binding protein 1 | 0.0605971 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0596894 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.05774 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.057407 |
| PCBP2 | poly(rC) binding protein 2 | 0.0563429 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0557338 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0556736 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0556221 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0533367 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0524492 |
| SMAD2 | SMAD family member 2 | 0.0523445 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0514112 |
| MAP7 | microtubule-associated protein 7 | 0.0512169 |
| PGK1 | phosphoglycerate kinase 1 | 0.0492333 |
| RPS12 | ribosomal protein S12 | 0.0481891 |
| MB21D2 | Mab-21 domain containing 2 | 0.0476072 |
| PALLD | palladin, cytoskeletal associated protein | 0.0469382 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0467266 |
| SET | SET nuclear proto-oncogene | 0.0463957 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.045495 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0449778 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0434059 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0433825 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0424253 |
| ANXA2 | annexin A2 | 0.0414058 |
| STC2 | stanniocalcin 2 | 0.0413465 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0410776 |
| RPL4 | ribosomal protein L4 | 0.0396263 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0393216 |
| KYNU | kynureninase | 0.0384361 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | 0.0376174 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0373264 |
| MSN | moesin | 0.0371631 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0365029 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0362635 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0352814 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0350031 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0348071 |
| CTIF | CBP80/20-dependent translation initiation factor | 0.0344744 |
| TPM3 | tropomyosin 3 | 0.0344525 |
| LSAMP | limbic system-associated membrane protein | 0.0344399 |
| RACK1 | receptor for activated C kinase 1 | 0.0342599 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | 0.0338316 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.0338034 |
| RPL3 | ribosomal protein L3 | 0.0334171 |
| RPS4X | ribosomal protein S4, X-linked | 0.0326409 |
| ENAH | enabled homolog (Drosophila) | 0.032512 |
| NTN4 | netrin 4 | 0.032507 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | 0.032228 |
| MGST1 | microsomal glutathione S-transferase 1 | 0.0316507 |
| DSTN | destrin (actin depolymerizing factor) | 0.0316459 |
| PRKD3 | protein kinase D3 | 0.0312874 |
| PTEN | phosphatase and tensin homolog | 0.0306774 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | 0.0304139 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0302282 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0301898 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0301324 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0298077 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0296888 |
| FMNL2 | formin-like 2 | 0.0294493 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0294186 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0290431 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | 0.0290125 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0289066 |
| EZR | ezrin | 0.0288468 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0285208 |
| ACBD6 | acyl-CoA binding domain containing 6 | 0.0280882 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0280466 |
| IPO7 | importin 7 | 0.0279367 |
| GRAMD1B | GRAM domain containing 1B | 0.0278149 |
| LAMA1 | laminin, alpha 1 | 0.0277697 |
| APP | amyloid beta (A4) precursor protein | 0.0275265 |
| MAN2A1 | mannosidase, alpha, class 2A, member 1 | 0.027337 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.178368 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.143436 |
| EFNA5 | ephrin-A5 | -0.140681 |
| FN1 | fibronectin 1 | -0.123858 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0967918 |
| TMSB10 | thymosin beta 10 | -0.093148 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0853889 |
| MCL1 | myeloid cell leukemia 1 | -0.0821455 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0647377 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0628359 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0612751 |
| STC1 | stanniocalcin 1 | -0.0585342 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0571653 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0561573 |
| HLA-B | major histocompatibility complex, class I, B | -0.0548569 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0539062 |
| RPL35A | ribosomal protein L35a | -0.0529611 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0467242 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0439865 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0433716 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0419497 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0414392 |
| CTNND2 | catenin (cadherin-associated protein), delta 2 | -0.0407068 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0390225 |
| RPL34 | ribosomal protein L34 | -0.0387981 |
| HLA-A | major histocompatibility complex, class I, A | -0.0386612 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.037197 |
| RPS29 | ribosomal protein S29 | -0.0370895 |
| RPS24 | ribosomal protein S24 | -0.0365847 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0348126 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0346216 |
| NRCAM | neuronal cell adhesion molecule | -0.0345958 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0339042 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0332302 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0328129 |
| RTN1 | reticulon 1 | -0.0320178 |
| CDH13 | cadherin 13 | -0.0315709 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0306094 |
| PTMA | prothymosin, alpha | -0.030509 |
| FNDC3B | fibronectin type III domain containing 3B | -0.029178 |
| SRGN | serglycin | -0.028321 |
| NDRG1 | N-myc downstream regulated 1 | -0.0268936 |
| NCKAP5 | NCK-associated protein 5 | -0.0267325 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0266862 |
| ADGRD1 | adhesion G protein-coupled receptor D1 | -0.026515 |
| GNAS | GNAS complex locus | -0.0264588 |
| FTL | ferritin, light polypeptide | -0.0263687 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0256184 |
| EGR1 | early growth response 1 | -0.0255237 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0252767 |
| RPLP2 | ribosomal protein, large, P2 | -0.0252357 |
| RPL38 | ribosomal protein L38 | -0.0251278 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0248786 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0248137 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0246792 |
| RPS11 | ribosomal protein S11 | -0.0246399 |
| RPS19 | ribosomal protein S19 | -0.0244909 |
| RPS8 | ribosomal protein S8 | -0.0237206 |
| ESM1 | endothelial cell-specific molecule 1 | -0.0235464 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0230891 |
| BMERB1 | bMERB domain containing 1 | -0.0229244 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0228552 |
| IL6 | interleukin 6 | -0.0226457 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0224689 |
| RTN4 | reticulon 4 | -0.0221482 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0218922 |
| RIGI | RNA sensor RIG-I | -0.0218215 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.021812 |
| RPLP1 | ribosomal protein, large, P1 | -0.0218065 |
| RPS13 | ribosomal protein S13 | -0.0214447 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0214237 |
| OGA | O-GlcNAcase | -0.021112 |
| RPL23 | ribosomal protein L23 | -0.0210549 |
| RPS15 | ribosomal protein S15 | -0.0209676 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0207906 |
| RPS21 | ribosomal protein S21 | -0.0204764 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | -0.0202718 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0199366 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0199133 |
| RPL31 | ribosomal protein L31 | -0.0196896 |
| CCL5 | chemokine (C-C motif) ligand 5 | -0.0191689 |
| RPS23 | ribosomal protein S23 | -0.0191416 |
| SRPK2 | SRSF protein kinase 2 | -0.018878 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0188752 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0187126 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0187095 |
| RPL37A | ribosomal protein L37a | -0.0187017 |
| VIM | vimentin | -0.0185991 |
| PDGFA | platelet-derived growth factor alpha polypeptide | -0.0182885 |
| LAMA5 | laminin, alpha 5 | -0.0181678 |
| FBXO11 | F-box protein 11 | -0.0181083 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0180275 |
| TMEM165 | transmembrane protein 165 | -0.017905 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0178562 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | -0.0177858 |
| ERO1B | endoplasmic reticulum oxidoreductase 1 beta | -0.0176779 |
| VMP1 | vacuole membrane protein 1 | -0.017639 |
| GLRX | glutaredoxin (thioltransferase) | -0.0175998 |
| RYR2 | ryanodine receptor 2 (cardiac) | -0.0174884 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0174663 |
