| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pralsetinib perturbation in NCI-H596 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pralsetinib_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.130488 |
| COL6A3 | collagen, type VI, alpha 3 | 0.120081 |
| STC1 | stanniocalcin 1 | 0.11536 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.113465 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.11299 |
| SMYD3 | SET and MYND domain containing 3 | 0.112881 |
| EXT1 | exostosin glycosyltransferase 1 | 0.108943 |
| CALD1 | caldesmon 1 | 0.108398 |
| FMN1 | formin 1 | 0.106914 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.106698 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.105353 |
| DIAPH2 | diaphanous-related formin 2 | 0.0975125 |
| INHBA | inhibin, beta A | 0.0950428 |
| FMNL2 | formin-like 2 | 0.0914987 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0912013 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0841016 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0824183 |
| VIM | vimentin | 0.0823526 |
| SQSTM1 | sequestosome 1 | 0.079888 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0778089 |
| ASPH | aspartate beta-hydroxylase | 0.0762735 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0755715 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0741906 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0735699 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0716738 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0700646 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0678195 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | 0.0658082 |
| NCOR1 | nuclear receptor corepressor 1 | 0.0626905 |
| SRPK2 | SRSF protein kinase 2 | 0.0618439 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0592984 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0592275 |
| GPC6 | glypican 6 | 0.0583728 |
| RPL35A | ribosomal protein L35a | 0.0576593 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0567079 |
| BBX | bobby sox homolog (Drosophila) | 0.055559 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0547269 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0535168 |
| RPL11 | ribosomal protein L11 | 0.0528335 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0518555 |
| FN1 | fibronectin 1 | 0.0512928 |
| RPS16 | ribosomal protein S16 | 0.0496657 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0495509 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0486891 |
| FAT1 | FAT atypical cadherin 1 | 0.0485482 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0475214 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0474154 |
| MYO1E | myosin IE | 0.0447044 |
| DCAF7 | DDB1 and CUL4 associated factor 7 | 0.0442862 |
| RPL38 | ribosomal protein L38 | 0.0442756 |
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | 0.044207 |
| SERPINB9 | serpin peptidase inhibitor, clade B (ovalbumin), member 9 | 0.0439949 |
| TPR | translocated promoter region, nuclear basket protein | 0.0439776 |
| VCL | vinculin | 0.0439161 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0438039 |
| HELZ | helicase with zinc finger | 0.0431699 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0425488 |
| ZFHX3 | zinc finger homeobox 3 | 0.0422258 |
| DST | dystonin | 0.0417643 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0417112 |
| VMP1 | vacuole membrane protein 1 | 0.0406964 |
| GPHN | gephyrin | 0.0400383 |
| NF1 | neurofibromin 1 | 0.0400285 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0396479 |
| ZNF292 | zinc finger protein 292 | 0.038436 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0375422 |
| SETD5 | SET domain containing 5 | 0.0370954 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0369938 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | 0.0363454 |
| SBF2 | SET binding factor 2 | 0.0356952 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0352031 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0351871 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0345446 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | 0.0342834 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0331748 |
| ERBIN | erbb2 interacting protein | 0.0322716 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0320073 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0317262 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0309437 |
| CALR | calreticulin | 0.0307855 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.0306467 |
| ENO1 | enolase 1, (alpha) | 0.0302655 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0301954 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0290519 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0288813 |
| PDS5B | PDS5 cohesin associated factor B | 0.0286091 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0284722 |
| AHNAK | AHNAK nucleoprotein | 0.0282959 |
| LMNA | lamin A/C | 0.0282674 |
| PTMA | prothymosin, alpha | 0.0282613 |
| GOLGA4 | golgin A4 | 0.0278504 |
| RPL13A | ribosomal protein L13a | 0.0278281 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0277162 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0274557 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0272928 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0271315 |
| ETNK1 | ethanolamine kinase 1 | 0.0258724 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0258209 |
| GOLGB1 | golgin B1 | 0.0250696 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0248309 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.202783 |
| LAMA4 | laminin, alpha 4 | -0.130827 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.129914 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.112632 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.109426 |
| EFNA5 | ephrin-A5 | -0.105988 |
| NDRG1 | N-myc downstream regulated 1 | -0.104627 |
| SLTM | SAFB-like, transcription modulator | -0.0986847 |
| RPL15 | ribosomal protein L15 | -0.0968602 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0961171 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0919409 |
| RPS13 | ribosomal protein S13 | -0.0916466 |
| EGR1 | early growth response 1 | -0.0889687 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0870831 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0806295 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0794217 |
| HMGA2 | high mobility group AT-hook 2 | -0.07884 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0748274 |
| RPL12 | ribosomal protein L12 | -0.0746358 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0746033 |
| TJP1 | tight junction protein 1 | -0.0714562 |
| PRKCA | protein kinase C, alpha | -0.070081 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0691523 |
| PRELID2 | PRELI domain containing 2 | -0.0689711 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0676271 |
| RAD51B | RAD51 paralog B | -0.0666636 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0666186 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0655825 |
| ANXA2 | annexin A2 | -0.0650516 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0626103 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0618265 |
| LAMC2 | laminin, gamma 2 | -0.0606124 |
| YAP1 | Yes-associated protein 1 | -0.0594785 |
| RPL36 | ribosomal protein L36 | -0.0583304 |
| RPL37A | ribosomal protein L37a | -0.0559805 |
| RPS19 | ribosomal protein S19 | -0.0556331 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0551944 |
| PDE8A | phosphodiesterase 8A | -0.0551252 |
| CLTC | clathrin, heavy chain (Hc) | -0.0547865 |
| RPL34 | ribosomal protein L34 | -0.0542174 |
| CDK13 | cyclin-dependent kinase 13 | -0.0535604 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0533913 |
| RSF1 | remodeling and spacing factor 1 | -0.0532333 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.052315 |
| RPL8 | ribosomal protein L8 | -0.0515177 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0513065 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0510232 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0505197 |
| S100A10 | S100 calcium binding protein A10 | -0.050302 |
| FAM13A | family with sequence similarity 13, member A | -0.0500606 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0485676 |
| MSI2 | musashi RNA-binding protein 2 | -0.0478633 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0473689 |
| UBC | ubiquitin C | -0.0463736 |
| COL5A1 | collagen, type V, alpha 1 | -0.0459267 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0453799 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0447906 |
| RTN4 | reticulon 4 | -0.0446155 |
| FBXW7 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | -0.0444533 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0435479 |
| TPD52 | tumor protein D52 | -0.0434904 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.042634 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.0424807 |
| CDH13 | cadherin 13 | -0.0421022 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0420292 |
| AREG | amphiregulin | -0.041926 |
| FHIT | fragile histidine triad | -0.0414788 |
| OGA | O-GlcNAcase | -0.0412597 |
| RPL30 | ribosomal protein L30 | -0.0402521 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0399811 |
| LAMB3 | laminin, beta 3 | -0.0399598 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0391275 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0389889 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0387804 |
| RPL31 | ribosomal protein L31 | -0.0381674 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.0381292 |
| OLA1 | Obg-like ATPase 1 | -0.0376357 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0368259 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0364754 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0359545 |
| ATXN1 | ataxin 1 | -0.0358341 |
| FLNB | filamin B, beta | -0.0355842 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0353315 |
| CANX | calnexin | -0.0351627 |
| RPL7 | ribosomal protein L7 | -0.0346155 |
| HDLBP | high density lipoprotein binding protein | -0.0339398 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0330906 |
| RPS4X | ribosomal protein S4, X-linked | -0.0328618 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0328113 |
| ZFC3H1 | zinc finger, C3H1-type containing | -0.0322887 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0318435 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0315936 |
| POTEF | POTE ankyrin domain family, member F | -0.0315037 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0307103 |
| FNIP1 | folliculin interacting protein 1 | -0.0302846 |
| MFF | mitochondrial fission factor | -0.0294687 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0294582 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0290248 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0285765 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0279969 |
