| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pralsetinib perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pralsetinib_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| COL11A1 | collagen, type XI, alpha 1 | 0.174985 |
| ANKRD33B | ankyrin repeat domain 33B | 0.101796 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0998887 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.080174 |
| PARD3B | par-3 family cell polarity regulator beta | 0.0735658 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0724423 |
| ENO1 | enolase 1, (alpha) | 0.066488 |
| FOXP2 | forkhead box P2 | 0.0662114 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0619847 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0614703 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0566774 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.053485 |
| COL5A2 | collagen, type V, alpha 2 | 0.0513817 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0513484 |
| RASAL2 | RAS protein activator like 2 | 0.0508836 |
| B2M | beta-2-microglobulin | 0.0505634 |
| PEG10 | paternally expressed 10 | 0.0503452 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0456806 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | 0.0455821 |
| CCDC88A | coiled-coil domain containing 88A | 0.0455588 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0449245 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0448876 |
| CSRNP3 | cysteine-serine-rich nuclear protein 3 | 0.0429959 |
| RPLP0 | ribosomal protein, large, P0 | 0.0425179 |
| SERTAD2 | SERTA domain containing 2 | 0.0406409 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.040614 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0405334 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0402959 |
| PTMA | prothymosin, alpha | 0.0398911 |
| PCBP2 | poly(rC) binding protein 2 | 0.0398546 |
| SYT1 | synaptotagmin I | 0.0386715 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0386407 |
| DENND4C | DENN/MADD domain containing 4C | 0.0386402 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0382249 |
| GPHN | gephyrin | 0.0381083 |
| LMO7 | LIM domain 7 | 0.0379154 |
| RAD51B | RAD51 paralog B | 0.0378787 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0375395 |
| ASPH | aspartate beta-hydroxylase | 0.0372898 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0368735 |
| FBXO11 | F-box protein 11 | 0.0366623 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0363607 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0362655 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0358819 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.035861 |
| XPO1 | exportin 1 | 0.035748 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0354051 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0350144 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0350141 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0349268 |
| DIAPH3 | diaphanous-related formin 3 | 0.034123 |
| APP | amyloid beta (A4) precursor protein | 0.0339396 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0339091 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0338497 |
| INTS6 | integrator complex subunit 6 | 0.0336038 |
| COL3A1 | collagen, type III, alpha 1 | 0.0324078 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0319408 |
| PCDH18 | protocadherin 18 | 0.0319139 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0316969 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.0310274 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | 0.030959 |
| FOXO1 | forkhead box O1 | 0.0305606 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0302524 |
| CALR | calreticulin | 0.0301414 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | 0.0300958 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0300883 |
| GOLGA4 | golgin A4 | 0.0300805 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0299701 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0297601 |
| RAB30 | RAB30, member RAS oncogene family | 0.0297531 |
| UBC | ubiquitin C | 0.0297287 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | 0.0295145 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0293414 |
| NDRG1 | N-myc downstream regulated 1 | 0.0293017 |
| ACIN1 | apoptotic chromatin condensation inducer 1 | 0.0286704 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | 0.0285763 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0285549 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.028495 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0284858 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0284774 |
| PHF3 | PHD finger protein 3 | 0.0284604 |
| FNBP1L | formin binding protein 1-like | 0.0280414 |
| ELOF1 | elongation factor 1 homolog (S. cerevisiae) | 0.0275982 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.027453 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0273452 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.027065 |
| PCM1 | pericentriolar material 1 | 0.0269359 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0269024 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | 0.0268061 |
| HDAC9 | histone deacetylase 9 | 0.0267398 |
| CTNNBL1 | catenin, beta like 1 | 0.0266184 |
| HMGB2 | high mobility group box 2 | 0.0265407 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0261759 |
| ZNF638 | zinc finger protein 638 | 0.0261685 |
| CDH19 | cadherin 19, type 2 | 0.0261148 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0260821 |
| CELF1 | CUGBP, Elav-like family member 1 | 0.02594 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | 0.0258984 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.025834 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0257756 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CADM2 | cell adhesion molecule 2 | -0.111646 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.106956 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.0996045 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0823727 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0813027 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0762911 |
| COL1A2 | collagen, type I, alpha 2 | -0.0760677 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | -0.0755087 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.0697378 |
| EMP1 | epithelial membrane protein 1 | -0.0628175 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0608359 |
| HS3ST5 | heparan sulfate (glucosamine) 3-O-sulfotransferase 5 | -0.0554317 |
| SRP54 | signal recognition particle 54kDa | -0.0541282 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0528223 |
| CDH4 | cadherin 4, type 1, R-cadherin (retinal) | -0.0526468 |
| NEBL | nebulette | -0.0519589 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | -0.0513184 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.050316 |
| VIM | vimentin | -0.0501586 |
| THOC2 | THO complex 2 | -0.0499767 |
| UPP1 | uridine phosphorylase 1 | -0.0498134 |
| SNX6 | sorting nexin 6 | -0.0484751 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0482629 |
| ADGRL3 | adhesion G protein-coupled receptor L3 | -0.0480337 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0473893 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0465451 |
| TMSB10 | thymosin beta 10 | -0.0463868 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0459347 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0455177 |
| MEIS2 | Meis homeobox 2 | -0.0443808 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0443765 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0427945 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0423434 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0420561 |
| PFN1 | profilin 1 | -0.0419063 |
| GALNTL6 | polypeptide N-acetylgalactosaminyltransferase-like 6 | -0.0418893 |
| GPC3 | glypican 3 | -0.0411836 |
| NRG1 | neuregulin 1 | -0.0403182 |
| DMD | dystrophin | -0.0402565 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0402085 |
| MAP4 | microtubule-associated protein 4 | -0.0396561 |
| SMYD3 | SET and MYND domain containing 3 | -0.0385492 |
| PLEKHB2 | pleckstrin homology domain containing, family B (evectins) member 2 | -0.0385387 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.0381534 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | -0.0372305 |
| ACTG1 | actin gamma 1 | -0.0369042 |
| CENPF | centromere protein F, 350/400kDa | -0.0368668 |
| RAI1 | retinoic acid induced 1 | -0.0359543 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0353418 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0348766 |
| UBE2K | ubiquitin-conjugating enzyme E2K | -0.034068 |
| RPL8 | ribosomal protein L8 | -0.0336574 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0334943 |
| POTEF | POTE ankyrin domain family, member F | -0.033082 |
| ZNF385D | zinc finger protein 385D | -0.0328742 |
| SETD5 | SET domain containing 5 | -0.0327617 |
| RPS2 | ribosomal protein S2 | -0.032332 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0319795 |
| CEP192 | centrosomal protein 192kDa | -0.0318956 |
| PHF21A | PHD finger protein 21A | -0.0317421 |
| RTN4 | reticulon 4 | -0.0314287 |
| NPAS3 | neuronal PAS domain protein 3 | -0.0312455 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0307377 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0304492 |
| LYST | lysosomal trafficking regulator | -0.0304327 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0302486 |
| FBXO17 | F-box protein 17 | -0.03014 |
| PPM1B | protein phosphatase, Mg2+/Mn2+ dependent, 1B | -0.0298755 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0297176 |
| KLHL5 | kelch-like family member 5 | -0.0296467 |
| RPS6 | ribosomal protein S6 | -0.0295985 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0291223 |
| RPS21 | ribosomal protein S21 | -0.0290114 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0287902 |
| FTL | ferritin, light polypeptide | -0.0286205 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0276777 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.027672 |
| ANXA1 | annexin A1 | -0.0274408 |
| ZDHHC20 | zinc finger, DHHC-type containing 20 | -0.0273859 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0272594 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | -0.0269592 |
| ZMYM4 | zinc finger, MYM-type 4 | -0.0266 |
| DENND5B | DENN/MADD domain containing 5B | -0.02614 |
| NKTR | natural killer cell triggering receptor | -0.0260887 |
| RFPL4B | ret finger protein-like 4B | -0.0257669 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0257351 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.025613 |
| TPX2 | TPX2, microtubule-associated | -0.0255233 |
| ASXL1 | additional sex combs like transcriptional regulator 1 | -0.025262 |
| RPS8 | ribosomal protein S8 | -0.0250675 |
| SBF2 | SET binding factor 2 | -0.0248989 |
| RPS13 | ribosomal protein S13 | -0.0248329 |
| RAB31 | RAB31, member RAS oncogene family | -0.024832 |
| RPS16 | ribosomal protein S16 | -0.0247879 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | -0.0247599 |
| RPL34 | ribosomal protein L34 | -0.024754 |
| RPL6 | ribosomal protein L6 | -0.0247447 |
| CERT1 | ceramide transporter 1 | -0.0246912 |
| RPLP2 | ribosomal protein, large, P2 | -0.024606 |
| SERF2 | small EDRK-rich factor 2 | -0.0245546 |
