| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pralsetinib perturbation in SNU-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pralsetinib_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.140705 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.106934 |
| TMSB4X | thymosin beta 4, X-linked | 0.104704 |
| EZR | ezrin | 0.0788592 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0757333 |
| ANXA1 | annexin A1 | 0.0700061 |
| HDAC9 | histone deacetylase 9 | 0.0591605 |
| PDGFC | platelet derived growth factor C | 0.0577072 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0487901 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0482819 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0474849 |
| ZNF608 | zinc finger protein 608 | 0.0471643 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0468675 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0466051 |
| SQSTM1 | sequestosome 1 | 0.0419114 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0401391 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0381743 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0378477 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.03755 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0371702 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.03618 |
| RPL3 | ribosomal protein L3 | 0.035929 |
| PGK1 | phosphoglycerate kinase 1 | 0.0345966 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.033991 |
| VCL | vinculin | 0.0337387 |
| ENO1 | enolase 1, (alpha) | 0.0336892 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.033554 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0334725 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0331158 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.033099 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | 0.0323602 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0319408 |
| CANX | calnexin | 0.0313735 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0312272 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0311806 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0311555 |
| RPL4 | ribosomal protein L4 | 0.0302981 |
| EML4 | echinoderm microtubule associated protein like 4 | 0.0301786 |
| RPL7 | ribosomal protein L7 | 0.0301293 |
| PLK2 | polo-like kinase 2 | 0.0297901 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0291151 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0286484 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 0.028078 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0280561 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0278841 |
| CREB5 | cAMP responsive element binding protein 5 | 0.0271229 |
| FN1 | fibronectin 1 | 0.026919 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0268503 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0268331 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0265985 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0257564 |
| FAT1 | FAT atypical cadherin 1 | 0.0257448 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0256774 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0256376 |
| USP47 | ubiquitin specific peptidase 47 | 0.025587 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0251645 |
| DST | dystonin | 0.0251372 |
| TRIM24 | tripartite motif containing 24 | 0.0248519 |
| HADHA | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit | 0.0247757 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0244047 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0244011 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0242585 |
| MKI67 | marker of proliferation Ki-67 | 0.0238783 |
| KIF5B | kinesin family member 5B | 0.0238487 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0234338 |
| CDC73 | cell division cycle 73 | 0.0233171 |
| CCDC68 | coiled-coil domain containing 68 | 0.0230338 |
| SOX6 | SRY (sex determining region Y)-box 6 | 0.0228024 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.022789 |
| ECT2 | epithelial cell transforming 2 | 0.0224324 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0223523 |
| CORO1C | coronin, actin binding protein, 1C | 0.0220436 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.021845 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0215664 |
| TAOK1 | TAO kinase 1 | 0.0214133 |
| YAP1 | Yes-associated protein 1 | 0.0213924 |
| CDK13 | cyclin-dependent kinase 13 | 0.0212341 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0212048 |
| LMO7 | LIM domain 7 | 0.021188 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0211773 |
| RAB14 | RAB14, member RAS oncogene family | 0.021002 |
| MED13 | mediator complex subunit 13 | 0.020931 |
| SGMS2 | sphingomyelin synthase 2 | 0.0209011 |
| RNF216 | ring finger protein 216 | 0.0208401 |
| MYOF | myoferlin | 0.0207186 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0203514 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0203054 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0202028 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0200287 |
| PTMA | prothymosin, alpha | 0.0199661 |
| LDHA | lactate dehydrogenase A | 0.0199444 |
| RPS18 | ribosomal protein S18 | 0.0196027 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0195701 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0195218 |
| RLF | rearranged L-myc fusion | 0.0192959 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.019225 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0192126 |
| CLTC | clathrin, heavy chain (Hc) | 0.0191943 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0191367 |
| B2M | beta-2-microglobulin | 0.0190775 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.229607 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.133962 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.101987 |
| PKM | pyruvate kinase, muscle | -0.0992428 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0910504 |
| B3GALT1 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 | -0.0823653 |
| AHNAK | AHNAK nucleoprotein | -0.0747494 |
| CACNB4 | calcium channel, voltage-dependent, beta 4 subunit | -0.0746685 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0701041 |
| CCND1 | cyclin D1 | -0.0647634 |
| BMP10 | bone morphogenetic protein 10 | -0.0629055 |
| FLNB | filamin B, beta | -0.0588982 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0574908 |
| NBEA | neurobeachin | -0.0555249 |
| ACTG1 | actin gamma 1 | -0.0515226 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0475841 |
| FHIT | fragile histidine triad | -0.0460159 |
| RPLP2 | ribosomal protein, large, P2 | -0.045156 |
| RPL35A | ribosomal protein L35a | -0.044328 |
| PFN1 | profilin 1 | -0.0428905 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0428644 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0421833 |
| GSE1 | Gse1 coiled-coil protein | -0.0415081 |
| GLI2 | GLI family zinc finger 2 | -0.040828 |
| RPS13 | ribosomal protein S13 | -0.0403791 |
| TXNRD1 | thioredoxin reductase 1 | -0.0389163 |
| S100A6 | S100 calcium binding protein A6 | -0.0376384 |
| RPL9 | ribosomal protein L9 | -0.0376138 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0370559 |
| TMSB10 | thymosin beta 10 | -0.0368873 |
| S100A4 | S100 calcium binding protein A4 | -0.0366657 |
| IGF2 | insulin-like growth factor 2 | -0.0356488 |
| FUS | FUS RNA binding protein | -0.0348538 |
| GPHN | gephyrin | -0.0342207 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.0341338 |
| RPL26 | ribosomal protein L26 | -0.0335796 |
| EVI5 | ecotropic viral integration site 5 | -0.0335742 |
| NFIA | nuclear factor I/A | -0.0332637 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0329093 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | -0.0328154 |
| RPL19 | ribosomal protein L19 | -0.03251 |
| GNAS | GNAS complex locus | -0.032349 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0320267 |
| RPLP1 | ribosomal protein, large, P1 | -0.030691 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0300711 |
| TMEM65 | transmembrane protein 65 | -0.0300145 |
| MT2A | metallothionein 2A | -0.0298997 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0294661 |
| ANKRD36 | ankyrin repeat domain 36 | -0.0294242 |
| GCNT1 | glucosaminyl (N-acetyl) transferase 1, core 2 | -0.0293939 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0291967 |
| RPL28 | ribosomal protein L28 | -0.0289553 |
| POTEF | POTE ankyrin domain family, member F | -0.0288844 |
| ALDH3A2 | aldehyde dehydrogenase 3 family, member A2 | -0.0284574 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | -0.0284345 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0282436 |
| RRBP1 | ribosome binding protein 1 | -0.0280396 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.027879 |
| RPL8 | ribosomal protein L8 | -0.0278494 |
| FTL | ferritin, light polypeptide | -0.0271815 |
| SLC1A3 | solute carrier family 1 (glial high affinity glutamate transporter), member 3 | -0.0270831 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0265936 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0265888 |
| LOXL3 | lysyl oxidase-like 3 | -0.0262962 |
| RPS11 | ribosomal protein S11 | -0.0262888 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0260933 |
| EBNA1BP2 | EBNA1 binding protein 2 | -0.0256172 |
| NEBL | nebulette | -0.0256068 |
| RPL37A | ribosomal protein L37a | -0.0252888 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0251189 |
| RPL23 | ribosomal protein L23 | -0.0250348 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0248237 |
| GCLM | glutamate-cysteine ligase, modifier subunit | -0.0244998 |
| S100A9 | S100 calcium binding protein A9 | -0.024039 |
| UNC13A | unc-13 homolog A (C. elegans) | -0.0239167 |
| PRDX2 | peroxiredoxin 2 | -0.0237851 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0237848 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | -0.0237789 |
| RPS21 | ribosomal protein S21 | -0.023494 |
| DCUN1D4 | DCN1, defective in cullin neddylation 1, domain containing 4 | -0.0231902 |
| NOP56 | NOP56 ribonucleoprotein | -0.0231316 |
| RPL34 | ribosomal protein L34 | -0.022693 |
| RPS25 | ribosomal protein S25 | -0.0226671 |
| PRELID2 | PRELI domain containing 2 | -0.0223722 |
| ANKRD36B | ankyrin repeat domain 36B | -0.0215963 |
| ENOX1 | ecto-NOX disulfide-thiol exchanger 1 | -0.0215822 |
| ONECUT2 | one cut homeobox 2 | -0.0215812 |
| MEIS2 | Meis homeobox 2 | -0.0215629 |
| RFC3 | replication factor C (activator 1) 3, 38kDa | -0.0214975 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0214643 |
| CCNI | cyclin I | -0.0213372 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0212823 |
| CBFB | core-binding factor, beta subunit | -0.0210248 |
| TNFRSF11B | tumor necrosis factor receptor superfamily, member 11b | -0.021013 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0208336 |
| XXYLT1 | xyloside xylosyltransferase 1 | -0.02071 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.0204532 |
| RPL36 | ribosomal protein L36 | -0.0203898 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0203428 |
| PRDX1 | peroxiredoxin 1 | -0.0199656 |
