| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pralsetinib perturbation in SNU-423 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Pralsetinib_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SOD2 | superoxide dismutase 2, mitochondrial | 0.223037 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.184687 |
| HDAC9 | histone deacetylase 9 | 0.151043 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.135538 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.105508 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0911356 |
| LDHA | lactate dehydrogenase A | 0.0845042 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0843234 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0771648 |
| B2M | beta-2-microglobulin | 0.0746444 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0744938 |
| ENO1 | enolase 1, (alpha) | 0.0734912 |
| CANX | calnexin | 0.0652422 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0632171 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0621184 |
| INTS6 | integrator complex subunit 6 | 0.0592485 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0574196 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0566045 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0563161 |
| CALR | calreticulin | 0.0555496 |
| VCL | vinculin | 0.0552259 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0549676 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0499123 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0468535 |
| VEGFA | vascular endothelial growth factor A | 0.0450608 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.04485 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0439766 |
| KYNU | kynureninase | 0.0417823 |
| SFTPA2 | surfactant protein A2 | 0.041061 |
| ASPH | aspartate beta-hydroxylase | 0.0405533 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0398659 |
| ATXN1 | ataxin 1 | 0.0395254 |
| BICC1 | BicC family RNA binding protein 1 | 0.0393935 |
| RPS12 | ribosomal protein S12 | 0.0391095 |
| SP100 | SP100 nuclear antigen | 0.0388464 |
| MSN | moesin | 0.0387022 |
| CTSA | cathepsin A | 0.0380828 |
| PCBP2 | poly(rC) binding protein 2 | 0.0372844 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.036632 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0365453 |
| SQSTM1 | sequestosome 1 | 0.0356935 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0356892 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0356747 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0355631 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0352997 |
| FNIP1 | folliculin interacting protein 1 | 0.035132 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0350746 |
| APP | amyloid beta (A4) precursor protein | 0.0349484 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0337444 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0329702 |
| RPLP0 | ribosomal protein, large, P0 | 0.0328842 |
| FUT11 | fucosyltransferase 11 (alpha (1,3) fucosyltransferase) | 0.0328619 |
| PLIN2 | perilipin 2 | 0.0321443 |
| DUSP10 | dual specificity phosphatase 10 | 0.0316789 |
| MYOF | myoferlin | 0.0313895 |
| TLE4 | transducin-like enhancer of split 4 | 0.0312183 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0310448 |
| C6ORF62 | chromosome 6 open reading frame 62 | 0.0309802 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0308766 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0307867 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0307198 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0300489 |
| VCAN | versican | 0.0299723 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0295942 |
| GOLGB1 | golgin B1 | 0.0294343 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.029434 |
| FLNA | filamin A, alpha | 0.029125 |
| PRELID2 | PRELI domain containing 2 | 0.0290568 |
| TRIM55 | tripartite motif containing 55 | 0.0287675 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0281059 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 0.0279483 |
| KIAA1217 | KIAA1217 | 0.0272205 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0271744 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0270418 |
| RPS4X | ribosomal protein S4, X-linked | 0.0269212 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.026798 |
| HLA-E | major histocompatibility complex, class I, E | 0.0265254 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0259157 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0257093 |
| ARRDC3 | arrestin domain containing 3 | 0.0256912 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.025152 |
| TPM3 | tropomyosin 3 | 0.0251351 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.025087 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0250765 |
| MORF4L2 | mortality factor 4 like 2 | 0.0246625 |
| RUNX1 | runt-related transcription factor 1 | 0.0246227 |
| GPC6 | glypican 6 | 0.0240497 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0239541 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0238975 |
| SVIL | supervillin | 0.023534 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0233742 |
| VIM | vimentin | 0.0233608 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.0231526 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0228609 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0224691 |
| BSG | basigin (Ok blood group) | 0.0224606 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0223667 |
| RPL7 | ribosomal protein L7 | 0.0222569 |
| RPL4 | ribosomal protein L4 | 0.0220557 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0216715 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NAMPT | nicotinamide phosphoribosyltransferase | -0.182031 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0921187 |
| NDRG1 | N-myc downstream regulated 1 | -0.0902094 |
| FRMD4A | FERM domain containing 4A | -0.087767 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0868944 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0852681 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0844576 |
| MT2A | metallothionein 2A | -0.0832339 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0818258 |
| FN1 | fibronectin 1 | -0.0777727 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0740216 |
| IER3 | immediate early response 3 | -0.0694228 |
| RTN4 | reticulon 4 | -0.066271 |
| RAI14 | retinoic acid induced 14 | -0.0651655 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0646626 |
| ADM | adrenomedullin | -0.0640356 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0637934 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0560397 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0558889 |
| GNAS | GNAS complex locus | -0.0520625 |
| HLA-B | major histocompatibility complex, class I, B | -0.0507791 |
| TPM4 | tropomyosin 4 | -0.0505724 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0504057 |
| COL1A1 | collagen, type I, alpha 1 | -0.0483967 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0483077 |
| ZNF292 | zinc finger protein 292 | -0.0463786 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0463736 |
| GLIS3 | GLIS family zinc finger 3 | -0.0443874 |
| PDE10A | phosphodiesterase 10A | -0.0430342 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0428766 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0409566 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0393748 |
| ATP13A3 | ATPase type 13A3 | -0.0393422 |
| SFRP1 | secreted frizzled-related protein 1 | -0.0388471 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0388384 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0387111 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0380084 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0373614 |
| CDCP1 | CUB domain containing protein 1 | -0.0366817 |
| ARFGAP3 | ADP-ribosylation factor GTPase activating protein 3 | -0.0362538 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.03591 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0356019 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0339133 |
| RBM39 | RNA binding motif protein 39 | -0.0334696 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0332288 |
| ACTG1 | actin gamma 1 | -0.0330521 |
| EGR1 | early growth response 1 | -0.0329774 |
| FTL | ferritin, light polypeptide | -0.0329203 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0325767 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0319845 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0317394 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0316325 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0312626 |
| DUSP5 | dual specificity phosphatase 5 | -0.0308174 |
| TMEM41B | transmembrane protein 41B | -0.0307364 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0304876 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.029778 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0297769 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0294237 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0293429 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0289907 |
| ANLN | anillin, actin binding protein | -0.0289842 |
| PHF21A | PHD finger protein 21A | -0.0283624 |
| RPL38 | ribosomal protein L38 | -0.0282944 |
| NAV1 | neuron navigator 1 | -0.0280112 |
| MAP4 | microtubule-associated protein 4 | -0.0279309 |
| FUS | FUS RNA binding protein | -0.027579 |
| TMSB10 | thymosin beta 10 | -0.0274872 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0274808 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0273763 |
| CLMP | CXADR-like membrane protein | -0.0273253 |
| TPM1 | tropomyosin 1 (alpha) | -0.0273135 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0272933 |
| AFAP1 | actin filament associated protein 1 | -0.0268157 |
| SRGN | serglycin | -0.0268101 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0267531 |
| SBF2 | SET binding factor 2 | -0.0261738 |
| FOXO3 | forkhead box O3 | -0.0260973 |
| DEK | DEK proto-oncogene | -0.0260694 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0256071 |
| CAVIN1 | caveolae associated protein 1 | -0.0252732 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0252289 |
| RRBP1 | ribosome binding protein 1 | -0.0248669 |
| ARF4 | ADP-ribosylation factor 4 | -0.0248048 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | -0.0246831 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0246546 |
| RPS24 | ribosomal protein S24 | -0.0243709 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0241358 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0241323 |
| OSMR | oncostatin M receptor | -0.0241103 |
| CENPF | centromere protein F, 350/400kDa | -0.0238612 |
| CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | -0.0238208 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0235351 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0235058 |
| THBS1 | thrombospondin 1 | -0.0232822 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0231446 |
| THOC2 | THO complex 2 | -0.0229227 |
| WDFY1 | WD repeat and FYVE domain containing 1 | -0.0226135 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0225519 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0225148 |
