| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pralsetinib perturbation in SW 1088 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Pralsetinib_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MYH9 | myosin, heavy chain 9, non-muscle | 0.169583 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.121971 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0945708 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0945134 |
| CANX | calnexin | 0.0869985 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0842777 |
| CD44 | CD44 molecule (Indian blood group) | 0.074735 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0626652 |
| B2M | beta-2-microglobulin | 0.0599772 |
| MSN | moesin | 0.0578615 |
| LDHA | lactate dehydrogenase A | 0.0566426 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0550403 |
| ENO1 | enolase 1, (alpha) | 0.0546124 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0525052 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0500741 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0490806 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0476131 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0470265 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0457763 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0457635 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0453593 |
| ZNF395 | zinc finger protein 395 | 0.0426011 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | 0.042592 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0419404 |
| FMNL2 | formin-like 2 | 0.0403889 |
| PTGES2 | prostaglandin E synthase 2 | 0.0398425 |
| GOLGB1 | golgin B1 | 0.0390182 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0383871 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0378879 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0375832 |
| KYNU | kynureninase | 0.0372965 |
| ECE1 | endothelin converting enzyme 1 | 0.0370154 |
| ARRDC3 | arrestin domain containing 3 | 0.0366661 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | 0.0359615 |
| MYO10 | myosin X | 0.0359562 |
| STC1 | stanniocalcin 1 | 0.0358434 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0356814 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0353356 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0348255 |
| PRELID2 | PRELI domain containing 2 | 0.0345022 |
| DSTN | destrin (actin depolymerizing factor) | 0.0340361 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0338067 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.033447 |
| TMF1 | TATA element modulatory factor 1 | 0.0333776 |
| MON2 | MON2 homolog (S. cerevisiae) | 0.0333757 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0325827 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0320406 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0311045 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0307052 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0305191 |
| SDC4 | syndecan 4 | 0.0304633 |
| MATR3 | matrin 3 | 0.0299314 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0299244 |
| RIGI | RNA sensor RIG-I | 0.0298447 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0298411 |
| PDIA5 | protein disulfide isomerase family A, member 5 | 0.029813 |
| INTS6 | integrator complex subunit 6 | 0.0297644 |
| TPM4 | tropomyosin 4 | 0.0295987 |
| CALR | calreticulin | 0.0294978 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0292735 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0291295 |
| VEGFA | vascular endothelial growth factor A | 0.0289512 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0287578 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | 0.0286022 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.028555 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0276774 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0276561 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0272919 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0271323 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.0270682 |
| HAPSTR1 | HUWE1 associated protein modifying stress responses | 0.0270424 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0267089 |
| ITGAV | integrin, alpha V | 0.0262786 |
| GOLGA4 | golgin A4 | 0.0262636 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0261577 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0260189 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0259762 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0258426 |
| ATXN1 | ataxin 1 | 0.0257584 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | 0.0255616 |
| SKIC3 | SKI3 subunit of superkiller complex | 0.0255156 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0254522 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0252232 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0251685 |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | 0.0251633 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0250192 |
| PCBP2 | poly(rC) binding protein 2 | 0.0249134 |
| ADNP | activity-dependent neuroprotector homeobox | 0.0246335 |
| PGM3 | phosphoglucomutase 3 | 0.0246045 |
| FAT1 | FAT atypical cadherin 1 | 0.0241685 |
| NRXN3 | neurexin 3 | 0.0240903 |
| HDAC9 | histone deacetylase 9 | 0.0239833 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.023963 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0239363 |
| CD47 | CD47 molecule | 0.0237624 |
| FUT11 | fucosyltransferase 11 (alpha (1,3) fucosyltransferase) | 0.0237364 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.0237147 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0236887 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0234839 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0234745 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.149913 |
| COL1A2 | collagen, type I, alpha 2 | -0.116817 |
| COL1A1 | collagen, type I, alpha 1 | -0.115763 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0930608 |
| CDH13 | cadherin 13 | -0.0920729 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0888287 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0855876 |
| FN1 | fibronectin 1 | -0.0719543 |
| HLA-B | major histocompatibility complex, class I, B | -0.0681527 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0587514 |
| MT1X | metallothionein 1X | -0.0559447 |
| POTEF | POTE ankyrin domain family, member F | -0.0558444 |
| KAZN | kazrin, periplakin interacting protein | -0.0539554 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0538884 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0523644 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0494616 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0481901 |
| PTMA | prothymosin, alpha | -0.0478908 |
| RAI14 | retinoic acid induced 14 | -0.0452873 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0440986 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0431219 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0423294 |
| HLA-A | major histocompatibility complex, class I, A | -0.0407096 |
| PRKCA | protein kinase C, alpha | -0.0395732 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0391408 |
| HLA-C | major histocompatibility complex, class I, C | -0.0389944 |
| FTL | ferritin, light polypeptide | -0.038206 |
| PKM | pyruvate kinase, muscle | -0.0371602 |
| PRSS23 | protease, serine, 23 | -0.0365679 |
| XPO1 | exportin 1 | -0.0363507 |
| EFNA5 | ephrin-A5 | -0.0363429 |
| ACTG1 | actin gamma 1 | -0.0360595 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0360307 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0359822 |
| TMEM263 | transmembrane protein 263 | -0.0348622 |
| PLOD1 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 | -0.0347476 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0347342 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0344373 |
| IL6 | interleukin 6 | -0.0324462 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0315858 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0300983 |
| RRBP1 | ribosome binding protein 1 | -0.0300193 |
| SMYD3 | SET and MYND domain containing 3 | -0.0298784 |
| TUBB | tubulin, beta class I | -0.0295578 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0291848 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0290785 |
| NAV1 | neuron navigator 1 | -0.0284331 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | -0.0281562 |
| CADM1 | cell adhesion molecule 1 | -0.0281036 |
| COL5A2 | collagen, type V, alpha 2 | -0.0276808 |
| CALU | calumenin | -0.0276488 |
| LMNA | lamin A/C | -0.0275218 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0273219 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0270711 |
| SEC24D | SEC24 family member D | -0.0267238 |
| TAGLN2 | transgelin 2 | -0.0263197 |
| EXOC4 | exocyst complex component 4 | -0.026034 |
| VCL | vinculin | -0.0257973 |
| ANLN | anillin, actin binding protein | -0.0257525 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0256598 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0256318 |
| FKBP10 | FK506 binding protein 10, 65 kDa | -0.0255702 |
| IGFBP7 | insulin-like growth factor binding protein 7 | -0.025218 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0250767 |
| FBN1 | fibrillin 1 | -0.0247906 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0245972 |
| CARD16 | caspase recruitment domain family, member 16 | -0.0241021 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0240462 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.0239457 |
| APOLD1 | apolipoprotein L domain containing 1 | -0.0237213 |
| TNS3 | tensin 3 | -0.0234407 |
| FUS | FUS RNA binding protein | -0.0234028 |
| RASAL2 | RAS protein activator like 2 | -0.0234006 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.022978 |
| EGR1 | early growth response 1 | -0.0229497 |
| RPL37A | ribosomal protein L37a | -0.0226172 |
| NABP1 | nucleic acid binding protein 1 | -0.0224829 |
| THY1 | Thy-1 cell surface antigen | -0.0222814 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0220921 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0220732 |
| MMP12 | matrix metallopeptidase 12 | -0.0220563 |
| CD109 | CD109 molecule | -0.0220132 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0219918 |
| SBF2 | SET binding factor 2 | -0.0219513 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0218344 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.021805 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0217805 |
| DIAPH3 | diaphanous-related formin 3 | -0.0217366 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0216547 |
| TXNIP | thioredoxin interacting protein | -0.0216044 |
| MMP14 | matrix metallopeptidase 14 (membrane-inserted) | -0.0215852 |
| RAB10 | RAB10, member RAS oncogene family | -0.0215587 |
| H3-3B | H3.3 histone B | -0.0215381 |
| DST | dystonin | -0.0214438 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0212329 |
| UBXN4 | UBX domain protein 4 | -0.0212277 |
| CHD6 | chromodomain helicase DNA binding protein 6 | -0.0209254 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0208664 |
| RPL31 | ribosomal protein L31 | -0.020834 |
| RRM2 | ribonucleotide reductase M2 | -0.020751 |
