Pralsetinib_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pralsetinib perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pralsetinib_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.139821
ZSWIM6 zinc finger, SWIM-type containing 6 0.129717
PALM2AKAP2 PALM2 and AKAP2 fusion 0.128272
LOC112694756 uncharaterized LOC112694756 0.102551
NFE2L2 nuclear factor, erythroid 2-like 2 0.0998625
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.097342
CD44 CD44 molecule (Indian blood group) 0.0928023
INTS6 integrator complex subunit 6 0.087416
BIRC3 baculoviral IAP repeat containing 3 0.0771061
MYH9 myosin, heavy chain 9, non-muscle 0.0745448
NCEH1 neutral cholesterol ester hydrolase 1 0.0647718
SQSTM1 sequestosome 1 0.0639473
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0610867
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0607786
IL6ST interleukin 6 signal transducer 0.0603297
SAMD4A sterile alpha motif domain containing 4A 0.0602383
ENO1 enolase 1, (alpha) 0.0569165
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0563938
DST dystonin 0.055214
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0551357
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0547303
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.054672
EIF5 eukaryotic translation initiation factor 5 0.0536208
TLE4 transducin-like enhancer of split 4 0.0532635
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0522956
IRAK2 interleukin-1 receptor-associated kinase 2 0.0509328
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0501959
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0500578
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0496499
SMAD3 SMAD family member 3 0.0484964
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0484552
TPI1 triosephosphate isomerase 1 0.0481161
MSN moesin 0.0477952
SVIL supervillin 0.0477232
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0472642
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0456977
ELL2 elongation factor, RNA polymerase II, 2 0.0450942
PRRC2C proline-rich coiled-coil 2C 0.0440513
RUNX1 runt-related transcription factor 1 0.0439499
TPT1 tumor protein, translationally-controlled 1 0.0433299
SMYD3 SET and MYND domain containing 3 0.042978
HSPA8 heat shock 70kDa protein 8 0.0427449
LOC102724023 ES1 protein homolog, mitochondrial 0.0426351
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0419034
ZNF638 zinc finger protein 638 0.0413226
ZFAND3 zinc finger, AN1-type domain 3 0.0411017
SET SET nuclear proto-oncogene 0.0399344
PDCD6IP programmed cell death 6 interacting protein 0.0395825
SH3KBP1 SH3-domain kinase binding protein 1 0.0386954
SIK2 salt-inducible kinase 2 0.0385782
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0382676
AKAP13 A kinase (PRKA) anchor protein 13 0.0376599
GPATCH2L G patch domain containing 2-like 0.0375409
LDHA lactate dehydrogenase A 0.0370296
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.036756
RPS12 ribosomal protein S12 0.0365348
HPCAL1 hippocalcin-like 1 0.035671
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0355628
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0352893
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0352015
AHNAK2 AHNAK nucleoprotein 2 0.0351447
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0349835
GOLGB1 golgin B1 0.0349668
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0343913
ADIPOR2 adiponectin receptor 2 0.0343072
B2M beta-2-microglobulin 0.0343027
EEA1 early endosome antigen 1 0.0342086
EHBP1 EH domain binding protein 1 0.0336484
RACK1 receptor for activated C kinase 1 0.0336386
BRD2 bromodomain containing 2 0.033269
SCAPER S-phase cyclin A-associated protein in the ER 0.0331369
BICD1 bicaudal D homolog 1 (Drosophila) 0.032865
DSCAM Down syndrome cell adhesion molecule 0.0328331
ARHGAP5 Rho GTPase activating protein 5 0.0325988
RPL36 ribosomal protein L36 0.0321099
UBXN7 UBX domain protein 7 0.0318303
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0312506
RPS3 ribosomal protein S3 0.0306595
TMED3 transmembrane emp24 protein transport domain containing 3 0.0305576
MACF1 microtubule-actin crosslinking factor 1 0.0305351
PEAK1 pseudopodium-enriched atypical kinase 1 0.0303452
ANKRD11 ankyrin repeat domain 11 0.0301776
MARCHF3 membrane associated ring-CH-type finger 3 0.0301689
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0299827
RAD23B RAD23 homolog B (S. cerevisiae) 0.02993
MBNL1 muscleblind-like splicing regulator 1 0.0299277
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0297121
TRIP12 thyroid hormone receptor interactor 12 0.0296706
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.029665
RAB7A RAB7A, member RAS oncogene family 0.0296471
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0296397
ZEB1 zinc finger E-box binding homeobox 1 0.0296255
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0288361
BZW1 basic leucine zipper and W2 domains 1 0.0286361
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 0.0285057
CLIP1 CAP-GLY domain containing linker protein 1 0.0281091
TAS2R14 taste receptor, type 2, member 14 0.0279532
C6ORF62 chromosome 6 open reading frame 62 0.0274431
ASPH aspartate beta-hydroxylase 0.0271849
APLP2 amyloid beta (A4) precursor-like protein 2 0.0270837

decreased expression

Symbol Name Standardized Value
HILPDA hypoxia inducible lipid droplet-associated -0.0849969
NDRG1 N-myc downstream regulated 1 -0.0806319
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0658383
IGF2 insulin-like growth factor 2 -0.0643141
IGFBP3 insulin-like growth factor binding protein 3 -0.0590743
PTMA prothymosin, alpha -0.0482369
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0455962
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0441089
UGCG UDP-glucose ceramide glucosyltransferase -0.043303
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0422909
SETD5 SET domain containing 5 -0.0421561
SNX14 sorting nexin 14 -0.0415819
ESYT2 extended synaptotagmin-like protein 2 -0.0397624
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0387627
GOLGA2 golgin A2 -0.0382765
RORA RAR-related orphan receptor A -0.0367116
MYO9B myosin IXB -0.0362957
ANKRD37 ankyrin repeat domain 37 -0.0359313
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0346613
SPAG9 sperm associated antigen 9 -0.0345865
DEK DEK proto-oncogene -0.0345102
VIM vimentin -0.0340847
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0339363
RIN2 Ras and Rab interactor 2 -0.0334866
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0325595
CAPRIN2 caprin family member 2 -0.0321894
UBE2K ubiquitin-conjugating enzyme E2K -0.0319491
FLNB filamin B, beta -0.0310442
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0310103
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0309942
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 -0.0309137
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0305825
HJURP Holliday junction recognition protein -0.0304618
FMN1 formin 1 -0.0304082
GPC6 glypican 6 -0.0303386
PYGL phosphorylase, glycogen, liver -0.0302913
COLEC11 collectin sub-family member 11 -0.0301751
DNER delta/notch-like EGF repeat containing -0.0301132
PDGFA platelet-derived growth factor alpha polypeptide -0.0300816
YBX3 Y box binding protein 3 -0.029994
DIAPH3 diaphanous-related formin 3 -0.0294877
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0293535
NHSL1 NHS-like 1 -0.0292224
THSD4 thrombospondin, type I, domain containing 4 -0.0286711
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.028536
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0279461
SEC24A SEC24 family member A -0.0279424
RNF149 ring finger protein 149 -0.0278251
KDM6A lysine (K)-specific demethylase 6A -0.0276169
SMC4 structural maintenance of chromosomes 4 -0.0274727
RAB5A RAB5A, member RAS oncogene family -0.0274721
TMSB10 thymosin beta 10 -0.0274184
NGLY1 N-glycanase 1 -0.0271943
ADM adrenomedullin -0.027179
ERBIN erbb2 interacting protein -0.0268587
KLHL24 kelch-like family member 24 -0.0266281
FOSL1 FOS-like antigen 1 -0.0266233
AHCTF1 AT hook containing transcription factor 1 -0.0261933
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.026113
BIRC6 baculoviral IAP repeat containing 6 -0.0261033
FNDC3B fibronectin type III domain containing 3B -0.0260039
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0258658
MARCHF7 membrane associated ring-CH-type finger 7 -0.0254284
ANLN anillin, actin binding protein -0.0251031
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 -0.0247062
DTNA dystrobrevin, alpha -0.0242584
RNF24 ring finger protein 24 -0.0240844
PFN1 profilin 1 -0.0239831
FAM13A family with sequence similarity 13, member A -0.0238871
ATXN2 ataxin 2 -0.0237998
DERA deoxyribose-phosphate aldolase (putative) -0.023621
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0235742
FNDC3A fibronectin type III domain containing 3A -0.0235633
ZMYND8 zinc finger, MYND-type containing 8 -0.0235315
DCBLD1 discoidin, CUB and LCCL domain containing 1 -0.0235015
FOXO3 forkhead box O3 -0.0233061
ZNF207 zinc finger protein 207 -0.0232564
KLC1 kinesin light chain 1 -0.0232482
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0230617
S100A9 S100 calcium binding protein A9 -0.0230583
MAP4 microtubule-associated protein 4 -0.0229419
TBC1D23 TBC1 domain family, member 23 -0.0229011
TENT2 terminal nucleotidyltransferase 2 -0.0227747
CREBRF CREB3 regulatory factor -0.0224746
BHLHE40 basic helix-loop-helix family, member e40 -0.0224452
CDK19 cyclin-dependent kinase 19 -0.02243
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0222287
ITGB5 integrin, beta 5 -0.0221841
NUP153 nucleoporin 153kDa -0.0221759
NALCN sodium leak channel, non selective -0.0219297
NCOA6 nuclear receptor coactivator 6 -0.021927
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0218518
DLG1 discs, large homolog 1 (Drosophila) -0.0217317
SPDL1 spindle apparatus coiled-coil protein 1 -0.0215235
RAI14 retinoic acid induced 14 -0.021519
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0214864
TENT4A terminal nucleotidyltransferase 4A -0.0214771
TMEM44 transmembrane protein 44 -0.0214657
TBK1 TANK-binding kinase 1 -0.021415
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0212584