| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pralsetinib perturbation in SW 900 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Pralsetinib_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0906455 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0818164 |
| STC2 | stanniocalcin 2 | 0.0771983 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0648886 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0629237 |
| CANX | calnexin | 0.0600452 |
| FAT1 | FAT atypical cadherin 1 | 0.0587751 |
| ENO1 | enolase 1, (alpha) | 0.053823 |
| MYOF | myoferlin | 0.0530158 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0525219 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0504583 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0453308 |
| INTS6 | integrator complex subunit 6 | 0.0434101 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0414887 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0388401 |
| CD109 | CD109 molecule | 0.0385013 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0382301 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0353022 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0352499 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0344571 |
| RPS12 | ribosomal protein S12 | 0.0341196 |
| DSTN | destrin (actin depolymerizing factor) | 0.0327367 |
| CALR | calreticulin | 0.0323546 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0321505 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0320426 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0319132 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0318004 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0313306 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.030563 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0304206 |
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | 0.0303544 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0297747 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0293946 |
| PLIN2 | perilipin 2 | 0.0292921 |
| GPATCH2L | G patch domain containing 2-like | 0.0290676 |
| AEBP2 | AE binding protein 2 | 0.0284807 |
| TUG1 | taurine up-regulated 1 (non-protein coding) | 0.0278213 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0266445 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0264653 |
| RACK1 | receptor for activated C kinase 1 | 0.0261064 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0260184 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0257542 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0253505 |
| SQSTM1 | sequestosome 1 | 0.0250954 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0243217 |
| PCBP3 | poly(rC) binding protein 3 | 0.0241624 |
| RUNX1 | runt-related transcription factor 1 | 0.0236551 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0236086 |
| TUFT1 | tuftelin 1 | 0.0235466 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0233182 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0232719 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0230616 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0230177 |
| AGPAT4 | 1-acylglycerol-3-phosphate O-acyltransferase 4 | 0.0226381 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0225272 |
| AHRR | aryl-hydrocarbon receptor repressor | 0.0224034 |
| UBAP2 | ubiquitin associated protein 2 | 0.0223728 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.022334 |
| RAB10 | RAB10, member RAS oncogene family | 0.0222838 |
| RBPMS | RNA binding protein with multiple splicing | 0.0218689 |
| DSG2 | desmoglein 2 | 0.0218128 |
| RASAL2 | RAS protein activator like 2 | 0.0217706 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0216446 |
| FNIP1 | folliculin interacting protein 1 | 0.0215539 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0214748 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0212771 |
| B2M | beta-2-microglobulin | 0.0212117 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0210339 |
| CCDC138 | coiled-coil domain containing 138 | 0.0210202 |
| CTBP2 | C-terminal binding protein 2 | 0.0207017 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0205897 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0203208 |
| APP | amyloid beta (A4) precursor protein | 0.0199211 |
| ENAH | enabled homolog (Drosophila) | 0.0198463 |
| TMF1 | TATA element modulatory factor 1 | 0.0196905 |
| GPC6 | glypican 6 | 0.0196009 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0192623 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0192472 |
| RPS27A | ribosomal protein S27a | 0.0191151 |
| PLK2 | polo-like kinase 2 | 0.0188713 |
| DST | dystonin | 0.0187148 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0186466 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0184769 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0184751 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0181611 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0181009 |
| SIPA1L2 | signal-induced proliferation-associated 1 like 2 | 0.017976 |
| ATF6 | activating transcription factor 6 | 0.0179681 |
| NXN | nucleoredoxin | 0.0177951 |
| FERMT2 | fermitin family member 2 | 0.0177017 |
| MMP13 | matrix metallopeptidase 13 | 0.0176949 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0176238 |
| SCFD1 | sec1 family domain containing 1 | 0.0174222 |
| CADM1 | cell adhesion molecule 1 | 0.0173421 |
| RPLP0 | ribosomal protein, large, P0 | 0.01715 |
| RPS3 | ribosomal protein S3 | 0.0171074 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0170854 |
| RFX2 | regulatory factor X, 2 (influences HLA class II expression) | 0.0168847 |
| MB21D2 | Mab-21 domain containing 2 | 0.0167959 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0167401 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.419025 |
| FN1 | fibronectin 1 | -0.219193 |
| NRG1 | neuregulin 1 | -0.138891 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.136118 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.117283 |
| HMGA2 | high mobility group AT-hook 2 | -0.116102 |
| ITGA1 | integrin, alpha 1 | -0.115491 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0998419 |
| TMSB10 | thymosin beta 10 | -0.0956393 |
| TMEM156 | transmembrane protein 156 | -0.0949346 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0884635 |
| OSMR | oncostatin M receptor | -0.0849525 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0778303 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0753571 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0681871 |
| NRP1 | neuropilin 1 | -0.066144 |
| ETV1 | ets variant 1 | -0.0654129 |
| MCTP2 | multiple C2 domains, transmembrane 2 | -0.0651149 |
| HLA-B | major histocompatibility complex, class I, B | -0.0639607 |
| TMEM165 | transmembrane protein 165 | -0.0638626 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0612026 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0595144 |
| S100A6 | S100 calcium binding protein A6 | -0.0588023 |
| NDRG1 | N-myc downstream regulated 1 | -0.0585601 |
| TXNIP | thioredoxin interacting protein | -0.0573115 |
| MT2A | metallothionein 2A | -0.0568909 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0540588 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0523775 |
| FNBP1 | formin binding protein 1 | -0.0507421 |
| KLHL5 | kelch-like family member 5 | -0.0503042 |
| RTN4 | reticulon 4 | -0.0494467 |
| SMOX | spermine oxidase | -0.0479522 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0460649 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0440027 |
| ACTN4 | actinin, alpha 4 | -0.0435419 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0435075 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.041655 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0412339 |
| FNDC3B | fibronectin type III domain containing 3B | -0.040365 |
| PKM | pyruvate kinase, muscle | -0.0390844 |
| ITGB5 | integrin, beta 5 | -0.0389482 |
| RPS21 | ribosomal protein S21 | -0.0387395 |
| PELO | pelota homolog (Drosophila) | -0.038671 |
| RPL35A | ribosomal protein L35a | -0.0385014 |
| HMGA1 | high mobility group AT-hook 1 | -0.0378676 |
| FOXP1 | forkhead box P1 | -0.0378278 |
| RBM39 | RNA binding motif protein 39 | -0.0377598 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0376759 |
| EGR1 | early growth response 1 | -0.0371402 |
| FTL | ferritin, light polypeptide | -0.0370848 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0359688 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.035839 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0349145 |
| GLIS3 | GLIS family zinc finger 3 | -0.0347441 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0342036 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0326701 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0324422 |
| GNAS | GNAS complex locus | -0.0320503 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0316804 |
| UBE2K | ubiquitin-conjugating enzyme E2K | -0.0310145 |
| CDC27 | cell division cycle 27 | -0.0309135 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0307542 |
| ETV6 | ets variant 6 | -0.0303428 |
| RRBP1 | ribosome binding protein 1 | -0.0300111 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0299205 |
| SYT1 | synaptotagmin I | -0.0295138 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0292486 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.029226 |
| PTK2 | protein tyrosine kinase 2 | -0.0291975 |
| RBM25 | RNA binding motif protein 25 | -0.0288995 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0288762 |
| CD44 | CD44 molecule (Indian blood group) | -0.0287393 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0285437 |
| IER3 | immediate early response 3 | -0.0285301 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0284365 |
| TGFA | transforming growth factor, alpha | -0.0283371 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0282015 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0281475 |
| MKI67 | marker of proliferation Ki-67 | -0.0281068 |
| PDE8A | phosphodiesterase 8A | -0.0279936 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0275164 |
| DUSP5 | dual specificity phosphatase 5 | -0.0265559 |
| TMEM263 | transmembrane protein 263 | -0.0264496 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0263796 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0262647 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0262475 |
| DNAH5 | dynein, axonemal, heavy chain 5 | -0.0259262 |
| CDCP1 | CUB domain containing protein 1 | -0.0258557 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0257935 |
| ZNF292 | zinc finger protein 292 | -0.0254138 |
| RPS11 | ribosomal protein S11 | -0.0252368 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0252273 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0251285 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0250922 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | -0.0248499 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0247053 |
| TSC22D1 | TSC22 domain family, member 1 | -0.0245855 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0244816 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0244167 |
| FAF2 | Fas associated factor family member 2 | -0.0243689 |
