| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | A member of the class of benzothiazoles that is 4,5,6,7-tetrahydro-1,3-benzothiazole in which the hydrogens at the 2 and 6-pro-S-positions are substituted by amino and propylamino groups, respectively. (Chemical Entities of Biological Interest Ontology, CHEBI_8356) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/119570 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in Pramipexole relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ZSCAN32 | zinc finger and SCAN domain containing 32 | 2.41 |
| CPLANE1 | ciliogenesis and planar polarity effector complex subunit 1 | 2.08 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | 1.28 |
| ALG12 | ALG12, alpha-1,6-mannosyltransferase | 0.91 |
| SLC30A6 | solute carrier family 30 (zinc transporter), member 6 | 0.78 |
| APC | adenomatous polyposis coli | 0.73 |
| WDR60 | WD repeat domain 60 | 0.73 |
| IL27RA | interleukin 27 receptor, alpha | 0.69 |
| SASH1 | SAM and SH3 domain containing 1 | 0.69 |
| TPM4 | tropomyosin 4 | 0.62 |
| KSR2 | kinase suppressor of ras 2 | 0.53 |
| PRKCH | protein kinase C, eta | 0.52 |
| PICK1 | protein interacting with PRKCA 1 | 0.52 |
| ASB8 | ankyrin repeat and SOCS box containing 8 | 0.5 |
| UEVLD | UEV and lactate/malate dehyrogenase domains | 0.5 |
| ZNF579 | zinc finger protein 579 | 0.49 |
| ZHX2 | zinc fingers and homeoboxes 2 | 0.48 |
| RHOC | ras homolog family member C | 0.47 |
| BDNF | brain-derived neurotrophic factor | 0.47 |
| LYSMD2 | LysM, putative peptidoglycan-binding, domain containing 2 | 0.46 |
| LNX2 | ligand of numb-protein X 2 | 0.44 |
| STYK1 | serine/threonine/tyrosine kinase 1 | 0.44 |
| TMEM200A | transmembrane protein 200A | 0.44 |
| COX7A2 | cytochrome c oxidase subunit VIIa polypeptide 2 (liver) | 0.43 |
| CNTRL | centriolin | 0.42 |
| ARL16 | ADP-ribosylation factor-like 16 | 0.4 |
| PRKCI | protein kinase C, iota | 0.4 |
| TOX2 | TOX high mobility group box family member 2 | 0.39 |
| ZNF532 | zinc finger protein 532 | 0.39 |
| ZNF696 | zinc finger protein 696 | 0.38 |
| FAM193B | family with sequence similarity 193, member B | 0.37 |
| SPOPL | speckle-type POZ protein-like | 0.37 |
| PTTG1 | pituitary tumor-transforming 1 | 0.37 |
| NME6 | NME/NM23 nucleoside diphosphate kinase 6 | 0.37 |
| ABCC9 | ATP-binding cassette, sub-family C (CFTR/MRP), member 9 | 0.36 |
| NKAPD1 | NKAP domain containing 1 | 0.36 |
| RPS24 | ribosomal protein S24 | 0.35 |
| RNF138 | ring finger protein 138, E3 ubiquitin protein ligase | 0.33 |
| FAM53B | family with sequence similarity 53, member B | 0.33 |
| FAM135A | family with sequence similarity 135, member A | 0.33 |
| CIAO2B | cytosolic iron-sulfur assembly component 2B | 0.33 |
| MYNN | myoneurin | 0.32 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.32 |
| C17ORF53 | chromosome 17 open reading frame 53 | 0.31 |
| KIAA1958 | KIAA1958 | 0.31 |
| TMEM102 | transmembrane protein 102 | 0.31 |
| C12ORF4 | chromosome 12 open reading frame 4 | 0.31 |
| DUSP6 | dual specificity phosphatase 6 | 0.31 |
| USP31 | ubiquitin specific peptidase 31 | 0.31 |
| ZNF791 | zinc finger protein 791 | 0.3 |
| C1ORF50 | chromosome 1 open reading frame 50 | 0.29 |
| ADAM19 | ADAM metallopeptidase domain 19 | 0.29 |
| VPS37C | vacuolar protein sorting 37 homolog C (S. cerevisiae) | 0.29 |
| CNEP1R1 | CTD nuclear envelope phosphatase 1 regulatory subunit 1 | 0.29 |
| ANKRD36C | ankyrin repeat domain 36C | 0.28 |
| TTC39B | tetratricopeptide repeat domain 39B | 0.28 |
| C5ORF34 | chromosome 5 open reading frame 34 | 0.28 |
| ZCCHC24 | zinc finger, CCHC domain containing 24 | 0.28 |
| CCNG1 | cyclin G1 | 0.28 |
| CDC25B | cell division cycle 25B | 0.28 |
| CHCHD2P9 | coiled-coil-helix-coiled-coil-helix domain containing 2 pseudogene 9 | 0.28 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.27 |
| SLC6A9 | solute carrier family 6 (neurotransmitter transporter, glycine), member 9 | 0.27 |
| CCNF | cyclin F | 0.27 |
| MTFP1 | mitochondrial fission process 1 | 0.27 |
| TPM3 | tropomyosin 3 | 0.27 |
| LIN7A | lin-7 homolog A (C. elegans) | 0.26 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.26 |
| MAP2K5 | mitogen-activated protein kinase kinase 5 | 0.26 |
| RGN | regucalcin | 0.26 |
| ZNRD1 | zinc ribbon domain containing 1 | 0.26 |
| PDCD7 | programmed cell death 7 | 0.26 |
| SRFBP1 | serum response factor binding protein 1 | 0.26 |
| RPL37A | ribosomal protein L37a | 0.26 |
| TRMT112 | tRNA methyltransferase 11-2 homolog (S. cerevisiae) | 0.25 |
| SATB2 | SATB homeobox 2 | 0.25 |
| PIK3C2B | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta | 0.25 |
| MNT | MAX network transcriptional repressor | 0.25 |
| ELK1 | ELK1, member of ETS oncogene family | 0.25 |
| TCP11L1 | t-complex 11, testis-specific-like 1 | 0.25 |
| FAM171A2 | family with sequence similarity 171, member A2 | 0.25 |
| PDGFRL | platelet-derived growth factor receptor-like | 0.25 |
| DNAH14 | dynein, axonemal, heavy chain 14 | 0.25 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.24 |
| ADGRF1 | adhesion G protein-coupled receptor F1 | 0.24 |
| REV1 | REV1, polymerase (DNA directed) | 0.24 |
| RBL2 | retinoblastoma-like 2 | 0.24 |
| POLR1D | polymerase (RNA) I polypeptide D, 16kDa | 0.24 |
| NOVA1 | neuro-oncological ventral antigen 1 | 0.24 |
| RPGR | retinitis pigmentosa GTPase regulator | 0.24 |
| RPS3A | ribosomal protein S3A | 0.24 |
| DPF1 | D4, zinc and double PHD fingers family 1 | 0.24 |
| NPHP4 | nephronophthisis 4 | 0.24 |
| PRDM4 | PR domain containing 4 | 0.24 |
| RPL32 | ribosomal protein L32 | 0.24 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.23 |
| ADIPOR1 | adiponectin receptor 1 | 0.23 |
| BMPR1A | bone morphogenetic protein receptor, type IA | 0.23 |
| POLR2L | polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa | 0.23 |
| GEN1 | GEN1 Holliday junction 5' flap endonuclease | 0.23 |
| Symbol | Name | Standardized Value |
|---|---|---|
| COL11A1 | collagen, type XI, alpha 1 | -1.01 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -0.79 |
| CRPPA | CDP-L-ribitol pyrophosphorylase A | -0.72 |
| PRDM2 | PR domain containing 2, with ZNF domain | -0.68 |
| PAQR7 | progestin and adipoQ receptor family member VII | -0.64 |
| UVRAG | UV radiation resistance associated | -0.62 |
| COL6A3 | collagen, type VI, alpha 3 | -0.61 |
| FTL | ferritin, light polypeptide | -0.59 |
| NPDC1 | neural proliferation, differentiation and control, 1 | -0.59 |
| RTN2 | reticulon 2 | -0.58 |
| DUS4L | dihydrouridine synthase 4-like (S. cerevisiae) | -0.57 |
| TBX3 | T-box 3 | -0.53 |
| LRP1 | low density lipoprotein receptor-related protein 1 | -0.53 |
| CLTA | clathrin, light chain A | -0.51 |
| TAF8 | TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa | -0.49 |
| MCOLN1 | mucolipin 1 | -0.48 |
| LYST | lysosomal trafficking regulator | -0.46 |
| HMCN1 | hemicentin 1 | -0.45 |
| PHYKPL | 5-phosphohydroxy-L-lysine phospho-lyase | -0.45 |
| MROH6 | maestro heat-like repeat family member 6 | -0.42 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.41 |
| RBPJL | recombination signal binding protein for immunoglobulin kappa J region-like | -0.41 |
| KCNAB2 | potassium channel, voltage gated subfamily A regulatory beta subunit 2 | -0.41 |
| COP1 | COP1 E3 ubiquitin ligase | -0.41 |
| PTGES | prostaglandin E synthase | -0.4 |
| FAM3A | family with sequence similarity 3, member A | -0.4 |
| C9ORF72 | chromosome 9 open reading frame 72 | -0.39 |
| LRRC8B | leucine rich repeat containing 8 family, member B | -0.39 |
| HBA1 | hemoglobin, alpha 1 | -0.38 |
| FZD3 | frizzled class receptor 3 | -0.38 |
| CGNL1 | cingulin-like 1 | -0.38 |
| RHBDF1 | rhomboid 5 homolog 1 (Drosophila) | -0.38 |
| RNF167 | ring finger protein 167 | -0.36 |
| CABLES1 | Cdk5 and Abl enzyme substrate 1 | -0.36 |
| ARAP2 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 | -0.35 |
| ZBTB4 | zinc finger and BTB domain containing 4 | -0.35 |
| NRBP2 | nuclear receptor binding protein 2 | -0.35 |
| STARD9 | StAR-related lipid transfer (START) domain containing 9 | -0.34 |
| YPEL5 | yippee-like 5 (Drosophila) | -0.34 |
| MSANTD3 | Myb/SANT-like DNA-binding domain containing 3 | -0.34 |
| PHLDB3 | pleckstrin homology-like domain, family B, member 3 | -0.34 |
| SERPINB8 | serpin peptidase inhibitor, clade B (ovalbumin), member 8 | -0.33 |
| GPRASP2 | G protein-coupled receptor associated sorting protein 2 | -0.33 |
| FAM102A | family with sequence similarity 102, member A | -0.33 |
| SAYSD1 | SAYSVFN motif domain containing 1 | -0.33 |
| SERINC1 | serine incorporator 1 | -0.33 |
| ISCA2 | iron-sulfur cluster assembly 2 | -0.32 |
| PLA2G6 | phospholipase A2, group VI (cytosolic, calcium-independent) | -0.32 |
| ARL14EPL | ADP-ribosylation factor-like 14 effector protein-like | -0.32 |
| NEO1 | neogenin 1 | -0.31 |
| LRP10 | low density lipoprotein receptor-related protein 10 | -0.31 |
| PRKAA2 | protein kinase, AMP-activated, alpha 2 catalytic subunit | -0.31 |
| ZNF397 | zinc finger protein 397 | -0.31 |
| FAM219A | family with sequence similarity 219, member A | -0.31 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | -0.31 |
| FGF2 | fibroblast growth factor 2 (basic) | -0.31 |
| HSP90AA4P | heat shock protein 90kDa alpha (cytosolic), class A member 4, pseudogene | -0.3 |
| ADGRG1 | adhesion G protein-coupled receptor G1 | -0.3 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.3 |
| TCAIM | T cell activation inhibitor, mitochondrial | -0.3 |
| ARHGEF37 | Rho guanine nucleotide exchange factor (GEF) 37 | -0.3 |
| TUBAL3 | tubulin, alpha-like 3 | -0.3 |
| PTBP1 | polypyrimidine tract binding protein 1 | -0.3 |
| FGG | fibrinogen gamma chain | -0.3 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.29 |
| SYDE2 | synapse defective 1, Rho GTPase, homolog 2 (C. elegans) | -0.29 |
| ZNF445 | zinc finger protein 445 | -0.29 |
| ABLIM3 | actin binding LIM protein family, member 3 | -0.29 |
| CTSL | cathepsin L | -0.28 |
| IPMK | inositol polyphosphate multikinase | -0.28 |
| C18ORF32 | chromosome 18 open reading frame 32 | -0.28 |
| HRH1 | histamine receptor H1 | -0.28 |
| RNASE4 | ribonuclease, RNase A family, 4 | -0.28 |
| WDR25 | WD repeat domain 25 | -0.28 |
| SH3YL1 | SH3 and SYLF domain containing 1 | -0.28 |
| ITGB1BP1 | integrin beta 1 binding protein 1 | -0.28 |
| PKM | pyruvate kinase, muscle | -0.27 |
| TSPAN15 | tetraspanin 15 | -0.27 |
| CHDH | choline dehydrogenase | -0.27 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.27 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.27 |
| ZNF839 | zinc finger protein 839 | -0.27 |
| INTU | inturned planar cell polarity protein | -0.27 |
| CMC4 | C-x(9)-C motif containing 4 | -0.27 |
| STK16 | serine/threonine kinase 16 | -0.27 |
| SBSN | suprabasin | -0.26 |
| FAT3 | FAT atypical cadherin 3 | -0.26 |
| TBC1D32 | TBC1 domain family, member 32 | -0.26 |
| PAH | phenylalanine hydroxylase | -0.26 |
| CREG1 | cellular repressor of E1A-stimulated genes 1 | -0.26 |
| MR1 | major histocompatibility complex, class I-related | -0.26 |
| FUNDC1 | FUN14 domain containing 1 | -0.26 |
| STARD5 | StAR-related lipid transfer (START) domain containing 5 | -0.26 |
| SLC29A2 | solute carrier family 29 (equilibrative nucleoside transporter), member 2 | -0.26 |
| MUC16 | mucin 16, cell surface associated | -0.26 |
| L1RE1 | LINE1 retrotransposable element 1 | -0.26 |
| MEST | mesoderm specific transcript | -0.26 |
| DEDD | death effector domain containing | -0.25 |
| CCDC158 | coiled-coil domain containing 158 | -0.25 |
