| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pravastatin (sodium) perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pravastatin (sodium)_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AREG | amphiregulin | 0.252136 |
| VIM | vimentin | 0.230151 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.172626 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.156387 |
| RPS12 | ribosomal protein S12 | 0.0907329 |
| ANXA1 | annexin A1 | 0.0841473 |
| ASPH | aspartate beta-hydroxylase | 0.0839862 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0799334 |
| TMEM41B | transmembrane protein 41B | 0.079714 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0781235 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0730236 |
| PCBP2 | poly(rC) binding protein 2 | 0.0721366 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0642237 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.0633057 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0624817 |
| RPL37A | ribosomal protein L37a | 0.0596285 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0591284 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0529272 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0516936 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0515677 |
| RPS3 | ribosomal protein S3 | 0.0510815 |
| RRM2 | ribonucleotide reductase M2 | 0.0471803 |
| RPS8 | ribosomal protein S8 | 0.0445321 |
| TXNRD1 | thioredoxin reductase 1 | 0.0441404 |
| KRR1 | KRR1, small subunit (SSU) processome component, homolog (yeast) | 0.0435351 |
| TPM3 | tropomyosin 3 | 0.043107 |
| VMP1 | vacuole membrane protein 1 | 0.042579 |
| RPS6 | ribosomal protein S6 | 0.0417209 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0387359 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | 0.0372598 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0371535 |
| HDGF | hepatoma-derived growth factor | 0.0353295 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0350225 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0343756 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0341438 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0333542 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0328618 |
| XPOT | exportin, tRNA | 0.0324475 |
| HSPA4 | heat shock 70kDa protein 4 | 0.0321053 |
| KIF5B | kinesin family member 5B | 0.0313578 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0311329 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | 0.0311285 |
| SET | SET nuclear proto-oncogene | 0.0303067 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0302172 |
| LDHB | lactate dehydrogenase B | 0.0292258 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0287218 |
| CPOX | coproporphyrinogen oxidase | 0.0285774 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0281211 |
| EZR | ezrin | 0.0273135 |
| RPS17 | ribosomal protein S17 | 0.026742 |
| NHSL1 | NHS-like 1 | 0.0262844 |
| HMGA2 | high mobility group AT-hook 2 | 0.0259125 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0256132 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0255317 |
| YEATS2 | YEATS domain containing 2 | 0.0253316 |
| PDGFC | platelet derived growth factor C | 0.0251925 |
| RPS2 | ribosomal protein S2 | 0.0250487 |
| SMYD3 | SET and MYND domain containing 3 | 0.0249015 |
| IPO7 | importin 7 | 0.0247443 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0242457 |
| NCKAP1 | NCK-associated protein 1 | 0.0237268 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.023352 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0232184 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0232107 |
| MAT2A | methionine adenosyltransferase II, alpha | 0.0229549 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0229094 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0224536 |
| LDHA | lactate dehydrogenase A | 0.0220659 |
| RPL5 | ribosomal protein L5 | 0.0220496 |
| MTAP | methylthioadenosine phosphorylase | 0.0220412 |
| RACK1 | receptor for activated C kinase 1 | 0.0220183 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.021967 |
| RPL23 | ribosomal protein L23 | 0.0217988 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0217921 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.021704 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0216729 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0215566 |
| XRN1 | 5'-3' exoribonuclease 1 | 0.0215137 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0214916 |
| SPATS2 | spermatogenesis associated, serine-rich 2 | 0.0214572 |
| ATP11A | ATPase, class VI, type 11A | 0.0213332 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0213068 |
| CDK19 | cyclin-dependent kinase 19 | 0.0212951 |
| RPS29 | ribosomal protein S29 | 0.0211818 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0210148 |
| PCDH9 | protocadherin 9 | 0.0208462 |
| RPS7 | ribosomal protein S7 | 0.0207007 |
| NECTIN3 | nectin cell adhesion molecule 3 | 0.0206868 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0204731 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | 0.0204661 |
| PRDX1 | peroxiredoxin 1 | 0.020401 |
| NEBL | nebulette | 0.020178 |
| CIP2A | cellular inhibitor of PP2A | 0.0198201 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0197161 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0195277 |
| XPO1 | exportin 1 | 0.019517 |
| PRELID2 | PRELI domain containing 2 | 0.0193686 |
| RPL3 | ribosomal protein L3 | 0.0192846 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.0191508 |
| CBX3 | chromobox homolog 3 | 0.0190593 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.198366 |
| NLGN1 | neuroligin 1 | -0.161812 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.123968 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0929231 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0743329 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0654234 |
| MMP12 | matrix metallopeptidase 12 | -0.0614739 |
| CCND1 | cyclin D1 | -0.058202 |
| HMGA1 | high mobility group AT-hook 1 | -0.0553633 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0540115 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0540086 |
| PCDH7 | protocadherin 7 | -0.0509089 |
| ZNF804A | zinc finger protein 804A | -0.0506637 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.048344 |
| EGR1 | early growth response 1 | -0.0454795 |
| NABP1 | nucleic acid binding protein 1 | -0.0437273 |
| H1-0 | H1.0 linker histone | -0.0423552 |
| FTL | ferritin, light polypeptide | -0.0422223 |
| NF1 | neurofibromin 1 | -0.0411189 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0410307 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0396171 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0392709 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0383305 |
| ZNF217 | zinc finger protein 217 | -0.0372641 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0369561 |
| TMSB10 | thymosin beta 10 | -0.0365723 |
| TMEM131 | transmembrane protein 131 | -0.0361488 |
| ERBIN | erbb2 interacting protein | -0.0358151 |
| HMGB1 | high mobility group box 1 | -0.0352824 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0350069 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0349691 |
| CCN2 | cellular communication network factor 2 | -0.0331389 |
| FBXO11 | F-box protein 11 | -0.0328974 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0328222 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.0322433 |
| ACTG1 | actin gamma 1 | -0.0319318 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0312574 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.0304837 |
| RBM39 | RNA binding motif protein 39 | -0.0302297 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0297853 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.029534 |
| DHX36 | DEAH (Asp-Glu-Ala-His) box polypeptide 36 | -0.0294561 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.029011 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0282109 |
| SPAG9 | sperm associated antigen 9 | -0.0280444 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0279937 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0279267 |
| PCNP | PEST proteolytic signal containing nuclear protein | -0.0278002 |
| GJA1 | gap junction protein, alpha 1, 43kDa | -0.027446 |
| RAP1GDS1 | RAP1, GTP-GDP dissociation stimulator 1 | -0.0268974 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.0268238 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0267733 |
| EDARADD | EDAR-associated death domain | -0.0265864 |
| NSD2 | nuclear receptor binding SET domain protein 2 | -0.0264045 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0260548 |
| AP3S1 | adaptor-related protein complex 3, sigma 1 subunit | -0.0255139 |
| HDLBP | high density lipoprotein binding protein | -0.0252458 |
| RPL8 | ribosomal protein L8 | -0.0250502 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.024425 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.0244024 |
| PDCD10 | programmed cell death 10 | -0.0241067 |
| ADIPOR2 | adiponectin receptor 2 | -0.0240062 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0238903 |
| FUS | FUS RNA binding protein | -0.0238255 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.023679 |
| LMO7 | LIM domain 7 | -0.0236366 |
| RPS24 | ribosomal protein S24 | -0.0230004 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0229729 |
| ECT2 | epithelial cell transforming 2 | -0.0229676 |
| TUT4 | terminal uridylyl transferase 4 | -0.0228353 |
| TGM2 | transglutaminase 2 | -0.0223827 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0223383 |
| TEAD4 | TEA domain family member 4 | -0.0222641 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0214939 |
| PRR11 | proline rich 11 | -0.021391 |
| RANBP17 | RAN binding protein 17 | -0.0213517 |
| NSUN6 | NOP2/Sun domain family, member 6 | -0.0213428 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0213398 |
| OXR1 | oxidation resistance 1 | -0.021337 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0213159 |
| FCHSD2 | FCH and double SH3 domains 2 | -0.021221 |
| RPL32 | ribosomal protein L32 | -0.0211965 |
| CDH12 | cadherin 12, type 2 (N-cadherin 2) | -0.0210199 |
| ACBD6 | acyl-CoA binding domain containing 6 | -0.02092 |
| RBMX | RNA binding motif protein, X-linked | -0.0207616 |
| IL6ST | interleukin 6 signal transducer | -0.0207184 |
| RPL38 | ribosomal protein L38 | -0.0206197 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0201128 |
| YBX3 | Y box binding protein 3 | -0.0198782 |
| TRMT112 | tRNA methyltransferase 11-2 homolog (S. cerevisiae) | -0.0197051 |
| LATS2 | large tumor suppressor kinase 2 | -0.0195804 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.0195727 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 | -0.0194884 |
| RPL12 | ribosomal protein L12 | -0.0192308 |
| CDK6 | cyclin-dependent kinase 6 | -0.0191754 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0191734 |
| TSC22D2 | TSC22 domain family, member 2 | -0.018932 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0189112 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0188355 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0185912 |
