| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pravastatin (sodium) perturbation in A498 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Pravastatin (sodium)_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | 0.170992 |
| NAV2 | neuron navigator 2 | 0.115161 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0877705 |
| RPL26 | ribosomal protein L26 | 0.0786262 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0768789 |
| MT2A | metallothionein 2A | 0.0764178 |
| RPL37A | ribosomal protein L37a | 0.0705299 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0704922 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0704168 |
| RPS8 | ribosomal protein S8 | 0.0700532 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0698234 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0656705 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0631876 |
| PTMA | prothymosin, alpha | 0.0603948 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.059693 |
| ATP13A3 | ATPase type 13A3 | 0.059053 |
| RPS6 | ribosomal protein S6 | 0.0579489 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0547008 |
| FRMD4A | FERM domain containing 4A | 0.0495606 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0493389 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0487357 |
| SEPTIN9 | septin 9 | 0.0473428 |
| RPS17 | ribosomal protein S17 | 0.047309 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0462619 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0457475 |
| HDGF | hepatoma-derived growth factor | 0.0449016 |
| TMSB10 | thymosin beta 10 | 0.044325 |
| IRS2 | insulin receptor substrate 2 | 0.0441861 |
| RPL23 | ribosomal protein L23 | 0.0434005 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0419401 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0414837 |
| RPS12 | ribosomal protein S12 | 0.041447 |
| SET | SET nuclear proto-oncogene | 0.0405079 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0403116 |
| CBX3 | chromobox homolog 3 | 0.0392022 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | 0.0391001 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0390973 |
| RPS27A | ribosomal protein S27a | 0.0385146 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0382606 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0377364 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0375229 |
| CADM1 | cell adhesion molecule 1 | 0.0374583 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0372384 |
| CAVIN1 | caveolae associated protein 1 | 0.037076 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0369941 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0352437 |
| AHNAK | AHNAK nucleoprotein | 0.0343748 |
| RACK1 | receptor for activated C kinase 1 | 0.0343487 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0340542 |
| RPLP2 | ribosomal protein, large, P2 | 0.0339787 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0339311 |
| RPS3 | ribosomal protein S3 | 0.0339189 |
| RPL31 | ribosomal protein L31 | 0.0336167 |
| CENPF | centromere protein F, 350/400kDa | 0.0335769 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0335708 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0327791 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0317638 |
| WDR43 | WD repeat domain 43 | 0.0316419 |
| PAX8 | paired box 8 | 0.0312286 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | 0.0311848 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.031144 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | 0.031108 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0306616 |
| RPL30 | ribosomal protein L30 | 0.0302143 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0301461 |
| ANXA5 | annexin A5 | 0.0301313 |
| OGA | O-GlcNAcase | 0.0296448 |
| BDP1 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | 0.0295398 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0294112 |
| RPS2 | ribosomal protein S2 | 0.0287965 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0287373 |
| TM9SF2 | transmembrane 9 superfamily member 2 | 0.0287232 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0283704 |
| FMNL2 | formin-like 2 | 0.0279789 |
| RAI14 | retinoic acid induced 14 | 0.0279377 |
| RPL9 | ribosomal protein L9 | 0.0277288 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0274685 |
| ARRDC3 | arrestin domain containing 3 | 0.0274236 |
| RPS19 | ribosomal protein S19 | 0.0270605 |
| RPS27 | ribosomal protein S27 | 0.0269429 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | 0.026938 |
| FAM107B | family with sequence similarity 107, member B | 0.0268787 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0258128 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0257471 |
| LMNA | lamin A/C | 0.0256558 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0254305 |
| CELF1 | CUGBP, Elav-like family member 1 | 0.0252766 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0250899 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | 0.0250503 |
| RNF149 | ring finger protein 149 | 0.0250422 |
| RPL5 | ribosomal protein L5 | 0.0249265 |
| ITSN2 | intersectin 2 | 0.024577 |
| DSTN | destrin (actin depolymerizing factor) | 0.0241719 |
| DENND2B | DENN domain containing 2B | 0.0240942 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0236028 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0234206 |
| PSMA5 | proteasome (prosome, macropain) subunit, alpha type, 5 | 0.0233696 |
| TPST1 | tyrosylprotein sulfotransferase 1 | 0.0231319 |
| GOLGA4 | golgin A4 | 0.023099 |
| CSNK1G1 | casein kinase 1, gamma 1 | 0.0227854 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.19765 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.163324 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.126433 |
| FTL | ferritin, light polypeptide | -0.118029 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.117099 |
| GLIS3 | GLIS family zinc finger 3 | -0.113853 |
| CP | ceruloplasmin (ferroxidase) | -0.0874904 |
| ASPH | aspartate beta-hydroxylase | -0.085306 |
| CSF1 | colony stimulating factor 1 (macrophage) | -0.0807054 |
| TXNRD1 | thioredoxin reductase 1 | -0.0784066 |
| CD44 | CD44 molecule (Indian blood group) | -0.0783982 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0735621 |
| GPC6 | glypican 6 | -0.067029 |
| RNF213 | ring finger protein 213 | -0.0655667 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0646876 |
| PFN1 | profilin 1 | -0.0641735 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0623349 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0617725 |
| RIGI | RNA sensor RIG-I | -0.059852 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0581875 |
| UBC | ubiquitin C | -0.0578849 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0566829 |
| HLA-B | major histocompatibility complex, class I, B | -0.0564005 |
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | -0.052781 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0527042 |
| MAP1B | microtubule-associated protein 1B | -0.0526004 |
| KYNU | kynureninase | -0.051395 |
| MX1 | MX dynamin-like GTPase 1 | -0.0506497 |
| CTSD | cathepsin D | -0.0495072 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0486742 |
| PALLD | palladin, cytoskeletal associated protein | -0.0486737 |
| CA12 | carbonic anhydrase XII | -0.0472558 |
| VCL | vinculin | -0.0453917 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0453876 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.0453845 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0442013 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0437507 |
| VCAM1 | vascular cell adhesion molecule 1 | -0.0425704 |
| PKM | pyruvate kinase, muscle | -0.0421032 |
| EGR1 | early growth response 1 | -0.0412201 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0402044 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0396856 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0396046 |
| ARF1 | ADP-ribosylation factor 1 | -0.0385073 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.03843 |
| GDF15 | growth differentiation factor 15 | -0.0381561 |
| NDRG1 | N-myc downstream regulated 1 | -0.0370446 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0367023 |
| OSMR | oncostatin M receptor | -0.0361494 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0360945 |
| TAGLN2 | transgelin 2 | -0.0358327 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0355609 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0354606 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0347069 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0345569 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0344571 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0339706 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0338574 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0326858 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0323426 |
| SP100 | SP100 nuclear antigen | -0.0321532 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0316873 |
| SETX | senataxin | -0.0315807 |
| ANXA2 | annexin A2 | -0.0315385 |
| ACLY | ATP citrate lyase | -0.0312756 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.031206 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0312009 |
| TUSC3 | tumor suppressor candidate 3 | -0.0311003 |
| HMGB1 | high mobility group box 1 | -0.0308347 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0307319 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0307275 |
| CXXC1 | CXXC finger protein 1 | -0.0303357 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0298923 |
| PLSCR1 | phospholipid scramblase 1 | -0.0295033 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0293156 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.028946 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0286957 |
| NRP1 | neuropilin 1 | -0.027861 |
| PLS3 | plastin 3 | -0.0277356 |
| ZNF644 | zinc finger protein 644 | -0.0277075 |
| HLA-C | major histocompatibility complex, class I, C | -0.0270361 |
| IRF1 | interferon regulatory factor 1 | -0.026913 |
| FN1 | fibronectin 1 | -0.0267591 |
| SCFD2 | sec1 family domain containing 2 | -0.0266305 |
| GCLM | glutamate-cysteine ligase, modifier subunit | -0.0265977 |
| INSIG1 | insulin induced gene 1 | -0.0264627 |
| ZNF207 | zinc finger protein 207 | -0.0264301 |
| SLC9A3R1 | solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 | -0.0255007 |
| TOB1 | transducer of ERBB2, 1 | -0.0252794 |
| PLK2 | polo-like kinase 2 | -0.0252674 |
| ACTG1 | actin gamma 1 | -0.0252563 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0251198 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.025075 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | -0.0250503 |
| FUS | FUS RNA binding protein | -0.0250449 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | -0.0249759 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0244649 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0243029 |
| MYADM | myeloid-associated differentiation marker | -0.0240515 |
| OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | -0.0238517 |
