Pravastatin (sodium)_HOP62 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pravastatin (sodium) perturbation in HOP62 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pravastatin (sodium)_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.215782
CXCL8 chemokine (C-X-C motif) ligand 8 0.143297
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.126907
MT2A metallothionein 2A 0.114315
FAM13A family with sequence similarity 13, member A 0.10266
PTMA prothymosin, alpha 0.096314
TRIO trio Rho guanine nucleotide exchange factor 0.0888723
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0879302
CDH13 cadherin 13 0.0697433
ADM adrenomedullin 0.0682239
OGA O-GlcNAcase 0.0669359
ANKRD11 ankyrin repeat domain 11 0.0655868
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0638749
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0626643
RPS8 ribosomal protein S8 0.0618574
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0568729
RPS6 ribosomal protein S6 0.0567834
UBA6 ubiquitin-like modifier activating enzyme 6 0.0559106
RPL12 ribosomal protein L12 0.0503921
COL5A1 collagen, type V, alpha 1 0.0486373
AKAP12 A kinase (PRKA) anchor protein 12 0.0480039
RPL9 ribosomal protein L9 0.0468583
JARID2 jumonji, AT rich interactive domain 2 0.0442572
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0435543
GRB10 growth factor receptor-bound protein 10 0.0434979
RPL26 ribosomal protein L26 0.0427591
DTNA dystrobrevin, alpha 0.0421798
BASP1 brain abundant, membrane attached signal protein 1 0.0412808
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0400543
RPS12 ribosomal protein S12 0.0393003
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0383849
G0S2 G0/G1 switch 2 0.0381272
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0380378
RPS3 ribosomal protein S3 0.0379653
LAMB3 laminin, beta 3 0.0376481
FGFR1 fibroblast growth factor receptor 1 0.0375126
RASA3 RAS p21 protein activator 3 0.0373284
FMNL2 formin-like 2 0.0357408
HPCAL1 hippocalcin-like 1 0.0352468
WSB1 WD repeat and SOCS box containing 1 0.0351355
BZW1 basic leucine zipper and W2 domains 1 0.0349903
TNS1 tensin 1 0.0349172
RPL23 ribosomal protein L23 0.0348049
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0346301
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0345315
FLNB filamin B, beta 0.033671
HILPDA hypoxia inducible lipid droplet-associated 0.0334252
RPL37A ribosomal protein L37a 0.0332108
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0328689
MAML3 mastermind-like 3 (Drosophila) 0.0325778
IRS2 insulin receptor substrate 2 0.0323116
NAMPT nicotinamide phosphoribosyltransferase 0.0314404
RAI1 retinoic acid induced 1 0.031002
RACK1 receptor for activated C kinase 1 0.0305413
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0303925
INHBA inhibin, beta A 0.0298103
TPT1 tumor protein, translationally-controlled 1 0.0284265
RPLP1 ribosomal protein, large, P1 0.028296
CD109 CD109 molecule 0.0282521
DDIT4 DNA-damage-inducible transcript 4 0.0279018
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0278571
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0276859
COL7A1 collagen, type VII, alpha 1 0.0275443
NAP1L1 nucleosome assembly protein 1-like 1 0.0274551
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0273112
APLP2 amyloid beta (A4) precursor-like protein 2 0.0269865
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 0.0266207
AMPD3 adenosine monophosphate deaminase 3 0.0264156
NAV1 neuron navigator 1 0.026237
SEPTIN9 septin 9 0.0262282
RPL11 ribosomal protein L11 0.0260237
RPLP0 ribosomal protein, large, P0 0.0259039
NGLY1 N-glycanase 1 0.0258016
RAP1B RAP1B, member of RAS oncogene family 0.0257204
RPL30 ribosomal protein L30 0.0256655
KLF6 Kruppel-like factor 6 0.025161
RPS27A ribosomal protein S27a 0.0249929
TPI1 triosephosphate isomerase 1 0.0248702
ATP13A3 ATPase type 13A3 0.0248298
RUNX1 runt-related transcription factor 1 0.0247254
TMSB10 thymosin beta 10 0.0243218
TGFB1 transforming growth factor, beta 1 0.0242099
SEC31A SEC31 homolog A (S. cerevisiae) 0.0241028
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0240931
PTPRF protein tyrosine phosphatase, receptor type, F 0.0239346
EEF1G eukaryotic translation elongation factor 1 gamma 0.0238967
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0238424
SPAG9 sperm associated antigen 9 0.0235634
SDK1 sidekick cell adhesion molecule 1 0.0234127
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0232899
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0232815
CLEC1B C-type lectin domain family 1, member B 0.0232486
NKTR natural killer cell triggering receptor 0.0231317
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.022924
ARHGAP22 Rho GTPase activating protein 22 0.0228358
SEC24A SEC24 family member A 0.0228182
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0227805
USP3 ubiquitin specific peptidase 3 0.0223674
RPL36 ribosomal protein L36 0.0222335
RICTOR RPTOR independent companion of MTOR, complex 2 0.0218988

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.390172
CD44 CD44 molecule (Indian blood group) -0.28646
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.189652
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.147598
IGF2 insulin-like growth factor 2 -0.103409
NDRG1 N-myc downstream regulated 1 -0.100791
GLIS3 GLIS family zinc finger 3 -0.0988204
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0971085
CDCP1 CUB domain containing protein 1 -0.0829412
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0767284
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0745749
RFX8 RFX family member 8, lacking RFX DNA binding domain -0.0735221
COL6A1 collagen, type VI, alpha 1 -0.0681738
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0652084
DST dystonin -0.0640808
PDIA3 protein disulfide isomerase family A, member 3 -0.0625716
BICD1 bicaudal D homolog 1 (Drosophila) -0.0585262
FN1 fibronectin 1 -0.0569841
LOC112694756 uncharaterized LOC112694756 -0.055158
LDHA lactate dehydrogenase A -0.0522501
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0514969
CENPF centromere protein F, 350/400kDa -0.0496545
MAP1B microtubule-associated protein 1B -0.0494921
IGFBP3 insulin-like growth factor binding protein 3 -0.0494433
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0491473
SYAP1 synapse associated protein 1 -0.0489664
PKM pyruvate kinase, muscle -0.0468752
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0444251
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0440749
ANKRD28 ankyrin repeat domain 28 -0.0435217
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0423566
ASPH aspartate beta-hydroxylase -0.0413586
ENO1 enolase 1, (alpha) -0.0408789
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0398718
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0397533
NALF1 NALCN channel auxiliary factor 1 -0.0390722
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0384154
PGK1 phosphoglycerate kinase 1 -0.0371535
DNMBP dynamin binding protein -0.0358136
TXNIP thioredoxin interacting protein -0.0348795
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0346589
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0345476
NECTIN2 nectin cell adhesion molecule 2 -0.0344049
CCND1 cyclin D1 -0.0343646
ZBTB20 zinc finger and BTB domain containing 20 -0.0338035
CLTC clathrin, heavy chain (Hc) -0.0329037
SMAD3 SMAD family member 3 -0.0323158
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0320764
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0320359
MSN moesin -0.0314143
ZBTB38 zinc finger and BTB domain containing 38 -0.0313701
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0312765
ACTN4 actinin, alpha 4 -0.0308142
GRAMD1B GRAM domain containing 1B -0.0307739
HSPA8 heat shock 70kDa protein 8 -0.0307531
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 -0.0305903
ACTG1 actin gamma 1 -0.0301513
WWTR1 WW domain containing transcription regulator 1 -0.0299025
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0297143
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0285683
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0285498
NRP1 neuropilin 1 -0.0283816
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.0279019
OSMR oncostatin M receptor -0.0278736
BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 -0.026539
TENM2 teneurin transmembrane protein 2 -0.0263023
FNDC3B fibronectin type III domain containing 3B -0.0261721
TXNRD1 thioredoxin reductase 1 -0.0259247
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0256699
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0254838
YES1 YES proto-oncogene 1, Src family tyrosine kinase -0.0254614
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0252039
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0249219
LOXL2 lysyl oxidase-like 2 -0.0248201
AXL AXL receptor tyrosine kinase -0.0247541
NECTIN3 nectin cell adhesion molecule 3 -0.0246859
LAMP2 lysosomal-associated membrane protein 2 -0.0244489
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0243736
VEGFC vascular endothelial growth factor C -0.0239355
BOD1L1 biorientation of chromosomes in cell division 1-like 1 -0.0239036
CD82 CD82 molecule -0.0234575
EPAS1 endothelial PAS domain protein 1 -0.0234362
SPIDR scaffolding protein involved in DNA repair -0.0233737
MKI67 marker of proliferation Ki-67 -0.0232076
TGFBI transforming growth factor, beta-induced, 68kDa -0.0230373
KDM2A lysine (K)-specific demethylase 2A -0.0229587
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0228583
HMGA1 high mobility group AT-hook 1 -0.02269
TPM1 tropomyosin 1 (alpha) -0.0226302
WNK1 WNK lysine deficient protein kinase 1 -0.0223997
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0223991
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0222643
USP34 ubiquitin specific peptidase 34 -0.0222291
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0216302
XPO1 exportin 1 -0.0215976
FER fer (fps/fes related) tyrosine kinase -0.0215953
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.021393
CLIC4 chloride intracellular channel 4 -0.0213175
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0212386
ANTXR1 anthrax toxin receptor 1 -0.0211796