| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pravastatin (sodium) perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pravastatin (sodium)_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ATP13A3 | ATPase type 13A3 | 0.183478 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.16135 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.14954 |
| TPM4 | tropomyosin 4 | 0.107987 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.100215 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0897644 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0756719 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0748986 |
| STC1 | stanniocalcin 1 | 0.0688944 |
| LOXL2 | lysyl oxidase-like 2 | 0.0682261 |
| SPAG9 | sperm associated antigen 9 | 0.0667254 |
| RPS8 | ribosomal protein S8 | 0.065235 |
| PTK2 | protein tyrosine kinase 2 | 0.0610402 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.059906 |
| RASA2 | RAS p21 protein activator 2 | 0.0572767 |
| CANX | calnexin | 0.055122 |
| SQLE | squalene epoxidase | 0.0548562 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0536561 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0530493 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0521292 |
| COL1A2 | collagen, type I, alpha 2 | 0.0518637 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0509576 |
| PDE10A | phosphodiesterase 10A | 0.0496767 |
| ZNF292 | zinc finger protein 292 | 0.049619 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0471453 |
| RPS6 | ribosomal protein S6 | 0.0467373 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0466213 |
| CAVIN1 | caveolae associated protein 1 | 0.0459599 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0446703 |
| RPS2 | ribosomal protein S2 | 0.0443776 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.04371 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0431563 |
| RPL26 | ribosomal protein L26 | 0.0416388 |
| RPL7 | ribosomal protein L7 | 0.041616 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0414126 |
| ADM | adrenomedullin | 0.0412976 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0406528 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0401951 |
| OGA | O-GlcNAcase | 0.0401589 |
| RPL12 | ribosomal protein L12 | 0.0393345 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0392946 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0385475 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0384767 |
| POSTN | periostin, osteoblast specific factor | 0.0384372 |
| VCAN | versican | 0.0382702 |
| CLMP | CXADR-like membrane protein | 0.0380696 |
| GOLGA4 | golgin A4 | 0.0376983 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0376354 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0372062 |
| TMEM41B | transmembrane protein 41B | 0.03711 |
| ECE1 | endothelin converting enzyme 1 | 0.0365902 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.036355 |
| ANXA5 | annexin A5 | 0.0356017 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | 0.0353104 |
| RPL13A | ribosomal protein L13a | 0.0352689 |
| MRTFA | myocardin related transcription factor A | 0.034798 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.0347304 |
| MRPS6 | mitochondrial ribosomal protein S6 | 0.0342657 |
| B2M | beta-2-microglobulin | 0.0341636 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0341458 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0336236 |
| ANXA2 | annexin A2 | 0.033302 |
| RLF | rearranged L-myc fusion | 0.0331473 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0330072 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0328288 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0324794 |
| TFG | TRK-fused gene | 0.0324589 |
| NAV2 | neuron navigator 2 | 0.0323871 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0319125 |
| AHNAK | AHNAK nucleoprotein | 0.0318272 |
| S100A6 | S100 calcium binding protein A6 | 0.0315751 |
| RPS12 | ribosomal protein S12 | 0.0313189 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0312263 |
| SRP54 | signal recognition particle 54kDa | 0.0310976 |
| SFTPA2 | surfactant protein A2 | 0.0309066 |
| ZNF148 | zinc finger protein 148 | 0.0302799 |
| NCKAP1 | NCK-associated protein 1 | 0.0296545 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.0295558 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.029227 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0289932 |
| CDC27 | cell division cycle 27 | 0.0289222 |
| RPS3 | ribosomal protein S3 | 0.028855 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0287607 |
| FLNB | filamin B, beta | 0.0284158 |
| EFNA5 | ephrin-A5 | 0.028407 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | 0.0281364 |
| SETD5 | SET domain containing 5 | 0.0281185 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.0278657 |
| PDE8A | phosphodiesterase 8A | 0.0277801 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0277466 |
| MED13L | mediator complex subunit 13-like | 0.0276897 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0276878 |
| RUNX1 | runt-related transcription factor 1 | 0.0276431 |
| RYK | receptor-like tyrosine kinase | 0.027565 |
| FOXJ3 | forkhead box J3 | 0.0271944 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0271275 |
| ELP2 | elongator acetyltransferase complex subunit 2 | 0.0268791 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0268432 |
| SYNJ2 | synaptojanin 2 | 0.0267515 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | 0.0267077 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.355776 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.268734 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.267426 |
| CD44 | CD44 molecule (Indian blood group) | -0.149501 |
| NDRG1 | N-myc downstream regulated 1 | -0.137754 |
| TMSB10 | thymosin beta 10 | -0.129242 |
| UBC | ubiquitin C | -0.101384 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0788587 |
| ENO1 | enolase 1, (alpha) | -0.0742968 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0616333 |
| ASPH | aspartate beta-hydroxylase | -0.0573554 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0554476 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0550224 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0514148 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0480294 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | -0.0470685 |
| MT1X | metallothionein 1X | -0.0466101 |
| RIGI | RNA sensor RIG-I | -0.0455428 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0444967 |
| EGR1 | early growth response 1 | -0.0400996 |
| JUN | jun proto-oncogene | -0.0380495 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.035647 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0354063 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0347825 |
| FN1 | fibronectin 1 | -0.0341139 |
| GLIS3 | GLIS family zinc finger 3 | -0.0333128 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0329989 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0328473 |
| PKM | pyruvate kinase, muscle | -0.0324678 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0324612 |
| RPS27A | ribosomal protein S27a | -0.0321944 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0313155 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0304772 |
| CALR | calreticulin | -0.0299244 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0296508 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0286358 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0278641 |
| RPS19 | ribosomal protein S19 | -0.0272582 |
| NAV1 | neuron navigator 1 | -0.027242 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0265162 |
| VCL | vinculin | -0.0259855 |
| OSMR | oncostatin M receptor | -0.0255933 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0254848 |
| FTL | ferritin, light polypeptide | -0.0249883 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0247033 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.0243998 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0235861 |
| COL1A1 | collagen, type I, alpha 1 | -0.0234393 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0233278 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0233261 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0228527 |
| HDAC9 | histone deacetylase 9 | -0.0226745 |
| TAPBP | TAP binding protein (tapasin) | -0.0224919 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0222947 |
| INTS6 | integrator complex subunit 6 | -0.0222725 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.022152 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0221098 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0220969 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0220127 |
| DPYSL2 | dihydropyrimidinase-like 2 | -0.0219939 |
| GPHN | gephyrin | -0.0219414 |
| IL6ST | interleukin 6 signal transducer | -0.0218801 |
| SEC24D | SEC24 family member D | -0.0215755 |
| ZFPM2 | zinc finger protein, FOG family member 2 | -0.0214128 |
| PRELID2 | PRELI domain containing 2 | -0.021234 |
| RAB5A | RAB5A, member RAS oncogene family | -0.0211095 |
| ATXN1 | ataxin 1 | -0.0211027 |
| AHR | aryl hydrocarbon receptor | -0.0209074 |
| EGFR | epidermal growth factor receptor | -0.020889 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0207659 |
| SP100 | SP100 nuclear antigen | -0.0206633 |
| NABP1 | nucleic acid binding protein 1 | -0.0203672 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0203543 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0201196 |
| SETX | senataxin | -0.0201135 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0197319 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0195783 |
| RPS5 | ribosomal protein S5 | -0.0193535 |
| CNTN5 | contactin 5 | -0.0190211 |
| DUSP6 | dual specificity phosphatase 6 | -0.0189691 |
| GLIPR1 | GLI pathogenesis-related 1 | -0.0189257 |
| KIAA1217 | KIAA1217 | -0.0188518 |
| HDLBP | high density lipoprotein binding protein | -0.0183391 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0182983 |
| SON | SON DNA binding protein | -0.0182022 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0179074 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0175749 |
| CD82 | CD82 molecule | -0.0175134 |
| GPC6 | glypican 6 | -0.0174991 |
| FER | fer (fps/fes related) tyrosine kinase | -0.0174824 |
| HLA-B | major histocompatibility complex, class I, B | -0.0173348 |
| SMYD3 | SET and MYND domain containing 3 | -0.0171928 |
| MSN | moesin | -0.0171317 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0170065 |
| VEGFA | vascular endothelial growth factor A | -0.0169371 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0168985 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.0167219 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | -0.0165048 |
| PPP3CC | protein phosphatase 3, catalytic subunit, gamma isozyme | -0.0164771 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.0164716 |
