Pravastatin (sodium)_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pravastatin (sodium) perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pravastatin (sodium)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.180502
FN1 fibronectin 1 0.129206
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.112212
RPS8 ribosomal protein S8 0.106483
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.103686
ENO1 enolase 1, (alpha) 0.102642
TIMP1 TIMP metallopeptidase inhibitor 1 0.0819935
PLIN2 perilipin 2 0.0805124
IGFBP1 insulin-like growth factor binding protein 1 0.0747526
CCL20 chemokine (C-C motif) ligand 20 0.0742805
RPL37A ribosomal protein L37a 0.074148
FNDC3B fibronectin type III domain containing 3B 0.0740146
AHSG alpha-2-HS-glycoprotein 0.0723289
FAT1 FAT atypical cadherin 1 0.0699582
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0680381
TF transferrin 0.0659903
RPL23 ribosomal protein L23 0.0649493
RPS6 ribosomal protein S6 0.064542
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0629693
TMSB10 thymosin beta 10 0.0622738
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0622436
APLP2 amyloid beta (A4) precursor-like protein 2 0.0611817
CANX calnexin 0.0572376
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0564652
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.056256
SEC31A SEC31 homolog A (S. cerevisiae) 0.0527683
HMGA1 high mobility group AT-hook 1 0.0525016
AFDN afadin, adherens junction formation factor 0.0509643
TOP1 topoisomerase (DNA) I 0.0489177
APOA2 apolipoprotein A-II 0.0482601
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0478406
EEF2 eukaryotic translation elongation factor 2 0.0470315
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0465532
ATXN1 ataxin 1 0.0462979
RPL26 ribosomal protein L26 0.0456017
RPS14 ribosomal protein S14 0.0455851
HOOK2 hook microtubule-tethering protein 2 0.0449317
RPS17 ribosomal protein S17 0.0448583
BIRC6 baculoviral IAP repeat containing 6 0.0426674
SVIL supervillin 0.0422978
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0421445
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0412821
DTNA dystrobrevin, alpha 0.0412049
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.041186
RPL31 ribosomal protein L31 0.0408204
RACK1 receptor for activated C kinase 1 0.0407773
EEF1G eukaryotic translation elongation factor 1 gamma 0.0405309
SBF2 SET binding factor 2 0.0404644
EXT1 exostosin glycosyltransferase 1 0.0399161
RPS12 ribosomal protein S12 0.0394713
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0392983
INSIG2 insulin induced gene 2 0.0390178
RPL34 ribosomal protein L34 0.0388128
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0386541
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0386395
FBF1 Fas (TNFRSF6) binding factor 1 0.038495
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0378845
ZNF292 zinc finger protein 292 0.0376942
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.0371663
PRRC2C proline-rich coiled-coil 2C 0.0371449
ACSL5 acyl-CoA synthetase long-chain family member 5 0.036886
ESYT2 extended synaptotagmin-like protein 2 0.0366063
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0366044
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.036109
TRIO trio Rho guanine nucleotide exchange factor 0.0359314
CAMTA1 calmodulin binding transcription activator 1 0.0358205
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0354744
RPL5 ribosomal protein L5 0.035412
ACTG1 actin gamma 1 0.0353193
FTH1 ferritin, heavy polypeptide 1 0.0350169
WDR45B WD repeat domain 45B 0.0347487
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.03472
TM4SF1 transmembrane 4 L six family member 1 0.0346191
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0345364
TPM4 tropomyosin 4 0.034457
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.034325
RPL35A ribosomal protein L35a 0.0341648
RPLP0 ribosomal protein, large, P0 0.0340811
UBA6 ubiquitin-like modifier activating enzyme 6 0.0340521
ARHGAP26 Rho GTPase activating protein 26 0.0336242
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0322767
SRPK1 SRSF protein kinase 1 0.0322172
GMDS GDP-mannose 4,6-dehydratase 0.0310367
ANXA5 annexin A5 0.0309479
KIF5B kinesin family member 5B 0.0306877
P4HB prolyl 4-hydroxylase, beta polypeptide 0.03066
PANK3 pantothenate kinase 3 0.0304847
PTK2 protein tyrosine kinase 2 0.0304249
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0303728
PHF3 PHD finger protein 3 0.0300629
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0298838
IRF2BP2 interferon regulatory factor 2 binding protein 2 0.0297285
HLF hepatic leukemia factor 0.0296145
RTN4 reticulon 4 0.0293623
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0293607
RPLP1 ribosomal protein, large, P1 0.0292694
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0292677
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0292108
PTPRF protein tyrosine phosphatase, receptor type, F 0.0290609
TNS1 tensin 1 0.029021

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.178562
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.169341
APOB apolipoprotein B -0.14524
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.141809
ERRFI1 ERBB receptor feedback inhibitor 1 -0.132893
GPC6 glypican 6 -0.0802807
C3 complement component 3 -0.0794815
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0676376
EHBP1 EH domain binding protein 1 -0.065677
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0594689
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 -0.0582634
MAML2 mastermind-like 2 (Drosophila) -0.0565848
RBM39 RNA binding motif protein 39 -0.0547679
VCL vinculin -0.0516571
SMAD3 SMAD family member 3 -0.0516369
DST dystonin -0.0487343
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 -0.0477698
SAMD4A sterile alpha motif domain containing 4A -0.0473016
PDGFB platelet-derived growth factor beta polypeptide -0.0447777
SDC4 syndecan 4 -0.0439953
ZBTB20 zinc finger and BTB domain containing 20 -0.0439934
NRIP1 nuclear receptor interacting protein 1 -0.0435422
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0420619
SELENOP selenoprotein P -0.0400562
GPATCH8 G patch domain containing 8 -0.0398606
PRKCA protein kinase C, alpha -0.039769
DNAH17 dynein, axonemal, heavy chain 17 -0.0393287
FRMD5 FERM domain containing 5 -0.0391464
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0386954
TRIM26 tripartite motif containing 26 -0.037671
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -0.0369371
USP34 ubiquitin specific peptidase 34 -0.0368914
TRIP12 thyroid hormone receptor interactor 12 -0.0364437
STAU1 staufen double-stranded RNA binding protein 1 -0.0358795
DLC1 DLC1 Rho GTPase activating protein -0.0354384
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 -0.0350294
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 -0.0325774
LCOR ligand dependent nuclear receptor corepressor -0.0324789
LCN2 lipocalin 2 -0.0324335
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0322348
PTPRM protein tyrosine phosphatase, receptor type, M -0.0318074
CNKSR3 CNKSR family member 3 -0.030355
RPS2 ribosomal protein S2 -0.0300982
RIGI RNA sensor RIG-I -0.0300901
MBNL3 muscleblind-like splicing regulator 3 -0.0299937
PDLIM5 PDZ and LIM domain 5 -0.029977
PEG10 paternally expressed 10 -0.0290363
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) -0.0289449
ADIPOR2 adiponectin receptor 2 -0.0288656
KTN1 kinectin 1 (kinesin receptor) -0.0282018
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0279513
DHRS2 dehydrogenase/reductase (SDR family) member 2 -0.0277574
BABAM2 BRISC and BRCA1 A complex member 2 -0.0276323
TMEM123 transmembrane protein 123 -0.0274828
ARL15 ADP-ribosylation factor-like 15 -0.0272299
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0271437
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0266413
ACYP2 acylphosphatase 2, muscle type -0.0262363
ZFHX3 zinc finger homeobox 3 -0.0259831
NPAS2 neuronal PAS domain protein 2 -0.0257507
ACTN4 actinin, alpha 4 -0.0256115
SLC2A14 solute carrier family 2 (facilitated glucose transporter), member 14 -0.0255543
PCSK6 proprotein convertase subtilisin/kexin type 6 -0.0255439
TNS3 tensin 3 -0.0254438
CMIP c-Maf inducing protein -0.0254293
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0248994
NABP1 nucleic acid binding protein 1 -0.024455
ITCH itchy E3 ubiquitin protein ligase -0.0241395
DOCK4 dedicator of cytokinesis 4 -0.0233425
ITGAV integrin, alpha V -0.0233165
NSUN6 NOP2/Sun domain family, member 6 -0.0231041
GNAS GNAS complex locus -0.0228418
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0228352
NKD1 naked cuticle homolog 1 (Drosophila) -0.0227751
FRAS1 Fraser extracellular matrix complex subunit 1 -0.0227658
CSNK1A1 casein kinase 1, alpha 1 -0.022738
ITGB5 integrin, beta 5 -0.0226987
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0226861
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like -0.0225919
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0225634
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0224978
CAPZB capping protein (actin filament) muscle Z-line, beta -0.0224003
FCHSD2 FCH and double SH3 domains 2 -0.0223781
BCL2L1 BCL2-like 1 -0.0223359
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0220868
FGA fibrinogen alpha chain -0.0218827
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0217279
MYH9 myosin, heavy chain 9, non-muscle -0.0216607
MAPK8 mitogen-activated protein kinase 8 -0.0214339
RNF213 ring finger protein 213 -0.0209926
TBC1D22A TBC1 domain family, member 22A -0.0208051
XPR1 xenotropic and polytropic retrovirus receptor 1 -0.0207886
ARPP19 cAMP-regulated phosphoprotein, 19kDa -0.0207316
EML4 echinoderm microtubule associated protein like 4 -0.0205692
NSD3 nuclear receptor binding SET domain protein 3 -0.0205375
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0200397
SOS1 son of sevenless homolog 1 (Drosophila) -0.0199972
SERINC3 serine incorporator 3 -0.0199346
SPIDR scaffolding protein involved in DNA repair -0.0198265
OSBPL10 oxysterol binding protein-like 10 -0.0196246