| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pravastatin (sodium) perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pravastatin (sodium)_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | 0.103347 |
| LAMC2 | laminin, gamma 2 | 0.0834146 |
| TOP1 | topoisomerase (DNA) I | 0.0659046 |
| SLTM | SAFB-like, transcription modulator | 0.0525554 |
| MT2A | metallothionein 2A | 0.0519692 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0474348 |
| LAMB3 | laminin, beta 3 | 0.0454051 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0445661 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0442468 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.043327 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0426391 |
| ASPH | aspartate beta-hydroxylase | 0.0419676 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0419542 |
| LAMA4 | laminin, alpha 4 | 0.0397604 |
| PCBP2 | poly(rC) binding protein 2 | 0.0383206 |
| RPL37A | ribosomal protein L37a | 0.0358123 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0340087 |
| RPS3 | ribosomal protein S3 | 0.0333989 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0333546 |
| RPS12 | ribosomal protein S12 | 0.0328222 |
| MGST1 | microsomal glutathione S-transferase 1 | 0.0319669 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.0306934 |
| RUNX1 | runt-related transcription factor 1 | 0.030302 |
| RNF149 | ring finger protein 149 | 0.0296238 |
| MKI67 | marker of proliferation Ki-67 | 0.0290262 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0271292 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.027101 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0264371 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0255312 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0254293 |
| NDE1 | nudE neurodevelopment protein 1 | 0.0251218 |
| RASA2 | RAS p21 protein activator 2 | 0.0247514 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0246577 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0245322 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.024483 |
| ZNF292 | zinc finger protein 292 | 0.0244659 |
| LANCL2 | LanC lantibiotic synthetase component C-like 2 (bacterial) | 0.023619 |
| RAB27B | RAB27B, member RAS oncogene family | 0.0235955 |
| AREG | amphiregulin | 0.0235268 |
| KYNU | kynureninase | 0.023461 |
| RBM25 | RNA binding motif protein 25 | 0.0225961 |
| ANO6 | anoctamin 6 | 0.0225376 |
| NGLY1 | N-glycanase 1 | 0.0224813 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0219913 |
| OSMR | oncostatin M receptor | 0.0218227 |
| RPL4 | ribosomal protein L4 | 0.021706 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0215921 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0212618 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0211497 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0210291 |
| GRAMD1B | GRAM domain containing 1B | 0.0207465 |
| B2M | beta-2-microglobulin | 0.0206925 |
| RNF145 | ring finger protein 145 | 0.0205601 |
| SEM1 | SEM1 26S proteasome subunit | 0.0204199 |
| ATAD2B | ATPase family, AAA domain containing 2B | 0.0202137 |
| DENND4A | DENN/MADD domain containing 4A | 0.0200002 |
| OGA | O-GlcNAcase | 0.0198425 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0195971 |
| ADGRF1 | adhesion G protein-coupled receptor F1 | 0.0192989 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0191727 |
| SCLT1 | sodium channel and clathrin linker 1 | 0.0191024 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0190306 |
| SEC61G | Sec61 gamma subunit | 0.0189658 |
| RPL26 | ribosomal protein L26 | 0.0186567 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0186083 |
| NCKAP1 | NCK-associated protein 1 | 0.0184799 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0182562 |
| KIAA1217 | KIAA1217 | 0.0181662 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0180178 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0179697 |
| CKAP5 | cytoskeleton associated protein 5 | 0.017591 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0174731 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0174665 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0172348 |
| TMEM41B | transmembrane protein 41B | 0.0170116 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.0169986 |
| ATP13A3 | ATPase type 13A3 | 0.0168199 |
| CAB39 | calcium binding protein 39 | 0.0164026 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0162494 |
| SEPTIN2 | septin 2 | 0.0160541 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | 0.0159619 |
| ELP2 | elongator acetyltransferase complex subunit 2 | 0.0159104 |
| SON | SON DNA binding protein | 0.0158835 |
| FAF2 | Fas associated factor family member 2 | 0.0158063 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0156632 |
| ANXA5 | annexin A5 | 0.0154456 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0154276 |
| SEPTIN10 | septin 10 | 0.0153143 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.015251 |
| NSUN6 | NOP2/Sun domain family, member 6 | 0.0151909 |
| XRN2 | 5'-3' exoribonuclease 2 | 0.0151866 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0149085 |
| MARF1 | meiosis regulator and mRNA stability factor 1 | 0.0148738 |
| PLEC | plectin | 0.0148631 |
| ST14 | suppression of tumorigenicity 14 (colon carcinoma) | 0.0148207 |
| GCLM | glutamate-cysteine ligase, modifier subunit | 0.0147558 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0147405 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0146237 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0145275 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0145007 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.595862 |
| EGFR | epidermal growth factor receptor | -0.171171 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.156504 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.153284 |
| NDRG1 | N-myc downstream regulated 1 | -0.119995 |
| EGR1 | early growth response 1 | -0.101032 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0959866 |
| INTS6 | integrator complex subunit 6 | -0.0673252 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0658975 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0638797 |
| PTMA | prothymosin, alpha | -0.0605589 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0605275 |
| S100A10 | S100 calcium binding protein A10 | -0.0567845 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0560998 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0549646 |
| ACTG1 | actin gamma 1 | -0.05312 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0523096 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0514016 |
| ANXA2 | annexin A2 | -0.0491494 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0487904 |
| MCL1 | myeloid cell leukemia 1 | -0.0468096 |
| H1-0 | H1.0 linker histone | -0.0457495 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0457314 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0441113 |
| MYOF | myoferlin | -0.0375916 |
| MAP3K13 | mitogen-activated protein kinase kinase kinase 13 | -0.0362662 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0343648 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0340556 |
| PDE8A | phosphodiesterase 8A | -0.0332857 |
| ENO1 | enolase 1, (alpha) | -0.0330603 |
| CES1 | carboxylesterase 1 | -0.0324058 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0321691 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.031968 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0316892 |
| RAB1A | RAB1A, member RAS oncogene family | -0.030971 |
| AGR2 | anterior gradient 2 | -0.0306762 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0302166 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0297205 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0296804 |
| MORF4L2 | mortality factor 4 like 2 | -0.0286968 |
| NABP1 | nucleic acid binding protein 1 | -0.0286928 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0286604 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | -0.0285154 |
| WASF2 | WAS protein family, member 2 | -0.0266906 |
| HBP1 | HMG-box transcription factor 1 | -0.0263013 |
| FUS | FUS RNA binding protein | -0.0262241 |
| GOLGB1 | golgin B1 | -0.024952 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0246544 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0245356 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0245305 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0241282 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0241042 |
| PHF21A | PHD finger protein 21A | -0.0235942 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0235689 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0235583 |
| IER3 | immediate early response 3 | -0.0234859 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0232808 |
| FTL | ferritin, light polypeptide | -0.0224527 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0224343 |
| CANX | calnexin | -0.0221908 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0216957 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0215222 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0215002 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0210875 |
| ANKRD37 | ankyrin repeat domain 37 | -0.0210111 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0208996 |
| DSPP | dentin sialophosphoprotein | -0.0208967 |
| KCMF1 | potassium channel modulatory factor 1 | -0.0206711 |
| EMP1 | epithelial membrane protein 1 | -0.0206364 |
| LDHA | lactate dehydrogenase A | -0.020628 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0202121 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0201864 |
| CALR | calreticulin | -0.0201335 |
| CDK2AP2 | cyclin-dependent kinase 2 associated protein 2 | -0.0200684 |
| ARF4 | ADP-ribosylation factor 4 | -0.019702 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0196423 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0194509 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | -0.0193589 |
| EZR | ezrin | -0.0190375 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0190337 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0190025 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0185834 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0185646 |
| JUN | jun proto-oncogene | -0.0184304 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0183619 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | -0.0183281 |
| HMGA1 | high mobility group AT-hook 1 | -0.018319 |
| ARF1 | ADP-ribosylation factor 1 | -0.0180865 |
| GNAS | GNAS complex locus | -0.0180715 |
| HDLBP | high density lipoprotein binding protein | -0.0179683 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0178686 |
| TMOD3 | tropomodulin 3 (ubiquitous) | -0.0176401 |
| CCND1 | cyclin D1 | -0.0175394 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0173864 |
| NF1 | neurofibromin 1 | -0.0173836 |
| JMJD1C | jumonji domain containing 1C | -0.0173241 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0172194 |
| RNF213 | ring finger protein 213 | -0.0171852 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.0170815 |
| CAV2 | caveolin 2 | -0.0169773 |
