Pravastatin (sodium)_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pravastatin (sodium) perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pravastatin (sodium)_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.205061
GRAMD1B GRAM domain containing 1B 0.177809
AKAP12 A kinase (PRKA) anchor protein 12 0.141686
TM4SF1 transmembrane 4 L six family member 1 0.0887956
VIM vimentin 0.0842534
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0750912
CXCL8 chemokine (C-X-C motif) ligand 8 0.0673166
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0668714
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.059484
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0590447
RPS12 ribosomal protein S12 0.0590002
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0548042
FAM107B family with sequence similarity 107, member B 0.0523493
RPS8 ribosomal protein S8 0.0522012
KTN1 kinectin 1 (kinesin receptor) 0.0517911
USP3 ubiquitin specific peptidase 3 0.0515228
RPL37A ribosomal protein L37a 0.0511885
SAMD4A sterile alpha motif domain containing 4A 0.0499725
NAMPT nicotinamide phosphoribosyltransferase 0.0493178
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0472818
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0466316
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.043846
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0436911
CAVIN1 caveolae associated protein 1 0.0433843
PYGL phosphorylase, glycogen, liver 0.0429444
NAP1L1 nucleosome assembly protein 1-like 1 0.042148
ANGPTL4 angiopoietin-like 4 0.0420354
APP amyloid beta (A4) precursor protein 0.0408313
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0407513
ANKRD11 ankyrin repeat domain 11 0.040555
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0404967
MYH9 myosin, heavy chain 9, non-muscle 0.0401176
PRRC2C proline-rich coiled-coil 2C 0.0390102
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0386915
JAK1 Janus kinase 1 0.0385166
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0358868
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0356038
HDGF hepatoma-derived growth factor 0.0355455
ELL2 elongation factor, RNA polymerase II, 2 0.0352314
CAMTA1 calmodulin binding transcription activator 1 0.0344705
RPL23 ribosomal protein L23 0.0344463
RBM25 RNA binding motif protein 25 0.0344048
FNDC3B fibronectin type III domain containing 3B 0.0342511
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0339413
BZW1 basic leucine zipper and W2 domains 1 0.0338406
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.033621
DGKD diacylglycerol kinase, delta 130kDa 0.0336093
MACF1 microtubule-actin crosslinking factor 1 0.0334159
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0330812
RTN4 reticulon 4 0.0327662
KDM3A lysine (K)-specific demethylase 3A 0.0325219
C15ORF48 chromosome 15 open reading frame 48 0.0324859
FAM168A family with sequence similarity 168, member A 0.0323755
YBX3 Y box binding protein 3 0.0323603
TFPI2 tissue factor pathway inhibitor 2 0.0322806
BCLAF1 BCL2-associated transcription factor 1 0.0322749
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0321048
BIRC2 baculoviral IAP repeat containing 2 0.0309623
S100A6 S100 calcium binding protein A6 0.0306542
NUP93 nucleoporin 93kDa 0.0302982
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0302654
SUB1 SUB1 homolog (S. cerevisiae) 0.0301851
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0301596
TRA2B transformer 2 beta homolog (Drosophila) 0.0299042
RASA2 RAS p21 protein activator 2 0.0297804
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.029565
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0291339
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0290524
RPL26 ribosomal protein L26 0.0290014
MCL1 myeloid cell leukemia 1 0.0288487
ACTN1 actinin, alpha 1 0.0282292
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0281379
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.027935
TPM3 tropomyosin 3 0.027912
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0271577
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0270534
TPD52 tumor protein D52 0.0270034
RPS17 ribosomal protein S17 0.0269862
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0267364
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0267297
WDR43 WD repeat domain 43 0.0267219
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0263053
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0262226
KPNA1 karyopherin alpha 1 (importin alpha 5) 0.026119
RPS7 ribosomal protein S7 0.0259949
SOD2 superoxide dismutase 2, mitochondrial 0.0256693
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0254378
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0252314
ZEB1 zinc finger E-box binding homeobox 1 0.02514
MPZL1 myelin protein zero-like 1 0.0248417
LAMC2 laminin, gamma 2 0.0246871
NCKAP1 NCK-associated protein 1 0.024571
RNF145 ring finger protein 145 0.0243723
TCEA1 transcription elongation factor A (SII), 1 0.0243423
ADAM9 ADAM metallopeptidase domain 9 0.0241841
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.024183
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0239322
DOCK4 dedicator of cytokinesis 4 0.0237558
CFLAR CASP8 and FADD-like apoptosis regulator 0.0237522
INHBA inhibin, beta A 0.023644

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.326714
FTL ferritin, light polypeptide -0.227049
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.165041
PM20D1 peptidase M20 domain containing 1 -0.127408
TXNRD1 thioredoxin reductase 1 -0.121608
FTH1 ferritin, heavy polypeptide 1 -0.10442
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0826737
IGF2 insulin-like growth factor 2 -0.0798054
ERBIN erbb2 interacting protein -0.0718593
KYNU kynureninase -0.06502
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0641607
THSD4 thrombospondin, type I, domain containing 4 -0.0585532
SLC38A2 solute carrier family 38, member 2 -0.0524394
BICC1 BicC family RNA binding protein 1 -0.0473185
HDAC9 histone deacetylase 9 -0.0462985
ACTG1 actin gamma 1 -0.0452035
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0451661
POTEF POTE ankyrin domain family, member F -0.0444139
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0442727
RPLP0 ribosomal protein, large, P0 -0.0437585
EFNA5 ephrin-A5 -0.0434335
EEF2 eukaryotic translation elongation factor 2 -0.0431031
NTN4 netrin 4 -0.0410656
HMGA1 high mobility group AT-hook 1 -0.0409152
ECT2 epithelial cell transforming 2 -0.0394149
RPS15 ribosomal protein S15 -0.0388608
EGR1 early growth response 1 -0.0373102
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.037267
PFN1 profilin 1 -0.0364596
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0346034
MBNL1 muscleblind-like splicing regulator 1 -0.0345701
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) -0.0345406
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0345021
RAD51B RAD51 paralog B -0.0344525
RPL8 ribosomal protein L8 -0.034452
RAB10 RAB10, member RAS oncogene family -0.033803
GLIS3 GLIS family zinc finger 3 -0.0327809
USP34 ubiquitin specific peptidase 34 -0.0320036
FBXO11 F-box protein 11 -0.0314738
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0313601
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0309785
PDIA3 protein disulfide isomerase family A, member 3 -0.0306841
EIF1 eukaryotic translation initiation factor 1 -0.0295866
NRG1 neuregulin 1 -0.0295451
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.0292275
SPRED2 sprouty-related, EVH1 domain containing 2 -0.028782
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0281321
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0280904
HMGB1 high mobility group box 1 -0.0280356
NRP1 neuropilin 1 -0.0272397
NEBL nebulette -0.0270455
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0269229
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0268347
ITCH itchy E3 ubiquitin protein ligase -0.0267409
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0266851
RPS23 ribosomal protein S23 -0.0262197
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0253618
CHD9 chromodomain helicase DNA binding protein 9 -0.0252799
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0251994
RAB7A RAB7A, member RAS oncogene family -0.0251733
PRR16 proline rich 16 -0.0250977
RPS16 ribosomal protein S16 -0.024765
UBC ubiquitin C -0.0246829
PDE4D phosphodiesterase 4D, cAMP-specific -0.0245898
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0238079
ANKRD17 ankyrin repeat domain 17 -0.0237169
CDK12 cyclin-dependent kinase 12 -0.0236588
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0234369
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0234024
FGG fibrinogen gamma chain -0.0233369
TNRC6B trinucleotide repeat containing 6B -0.023262
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0232612
BICD1 bicaudal D homolog 1 (Drosophila) -0.0230019
RAB1A RAB1A, member RAS oncogene family -0.0227354
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0227071
TNPO1 transportin 1 -0.0226486
EXOC6B exocyst complex component 6B -0.0226342
ADNP activity-dependent neuroprotector homeobox -0.0224874
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) -0.022458
CUX1 cut-like homeobox 1 -0.0221614
RPL19 ribosomal protein L19 -0.0219322
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0217741
ZNF804A zinc finger protein 804A -0.0214529
MSRB3 methionine sulfoxide reductase B3 -0.0212704
ACBD3 acyl-CoA binding domain containing 3 -0.0211742
VDAC1 voltage-dependent anion channel 1 -0.0208903
TFG TRK-fused gene -0.0207954
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0207664
SPIDR scaffolding protein involved in DNA repair -0.0207146
RPS29 ribosomal protein S29 -0.0205126
DENND5B DENN/MADD domain containing 5B -0.0204537
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0203987
RPS5 ribosomal protein S5 -0.020385
SERF2 small EDRK-rich factor 2 -0.0202253
TMEM87A transmembrane protein 87A -0.0201652
BHLHE40 basic helix-loop-helix family, member e40 -0.0201325
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0200972
ASTN2 astrotactin 2 -0.0197395
ETFA electron-transfer-flavoprotein, alpha polypeptide -0.0192982
INO80 INO80 complex subunit -0.0192483