Pravastatin (sodium)_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pravastatin (sodium) perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pravastatin (sodium)_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.207923
NDRG1 N-myc downstream regulated 1 0.154124
EGFR epidermal growth factor receptor 0.124782
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.100309
CD44 CD44 molecule (Indian blood group) 0.0975788
ZNF292 zinc finger protein 292 0.0846273
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0827368
VIM vimentin 0.0793815
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.076525
ERRFI1 ERBB receptor feedback inhibitor 1 0.0749911
TRIO trio Rho guanine nucleotide exchange factor 0.0745258
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0731339
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0692875
CALR calreticulin 0.066649
CXCL8 chemokine (C-X-C motif) ligand 8 0.0663206
FAM13A family with sequence similarity 13, member A 0.0642261
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0622358
GARS1 glycyl-tRNA synthetase 1 0.0595641
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0592778
AKAP12 A kinase (PRKA) anchor protein 12 0.0590068
EHBP1 EH domain binding protein 1 0.0587336
STK17A serine/threonine kinase 17a 0.0579027
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0575533
ATXN1 ataxin 1 0.0572897
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0566207
PGK1 phosphoglycerate kinase 1 0.0549442
NUP58 nucleoporin 58 0.0546897
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0540879
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0532448
FNDC3B fibronectin type III domain containing 3B 0.052574
ADAM9 ADAM metallopeptidase domain 9 0.0524888
LDHA lactate dehydrogenase A 0.0511866
PCNX1 pecanex 1 0.0506153
PHIP pleckstrin homology domain interacting protein 0.04822
KTN1 kinectin 1 (kinesin receptor) 0.0480875
MT2A metallothionein 2A 0.0469261
DTNA dystrobrevin, alpha 0.0466416
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0455827
NBAS neuroblastoma amplified sequence 0.0450187
MXI1 MAX interactor 1, dimerization protein 0.0449509
TUT4 terminal uridylyl transferase 4 0.0449172
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0449164
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0444991
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0444062
FMNL2 formin-like 2 0.0439965
CSDE1 cold shock domain containing E1, RNA-binding 0.0438677
BTG1 B-cell translocation gene 1, anti-proliferative 0.043168
SERBP1 SERPINE1 mRNA binding protein 1 0.0430438
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0429442
ZNF654 zinc finger protein 654 0.0426922
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0418054
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0416311
THSD4 thrombospondin, type I, domain containing 4 0.0415383
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0411825
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0411652
QKI QKI, KH domain containing, RNA binding 0.0409049
FLNB filamin B, beta 0.0405089
HP1BP3 heterochromatin protein 1, binding protein 3 0.0403195
USP37 ubiquitin specific peptidase 37 0.040196
RB1CC1 RB1-inducible coiled-coil 1 0.0395118
TXNRD1 thioredoxin reductase 1 0.0393194
ANXA2 annexin A2 0.0389113
KYNU kynureninase 0.0385124
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0384399
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0382536
PDIA6 protein disulfide isomerase family A, member 6 0.0382167
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0379041
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0372523
PTMA prothymosin, alpha 0.037197
NAMPT nicotinamide phosphoribosyltransferase 0.0370872
NOP58 NOP58 ribonucleoprotein 0.0369425
STRN striatin, calmodulin binding protein 0.0366349
LCOR ligand dependent nuclear receptor corepressor 0.0365211
RAI1 retinoic acid induced 1 0.0364211
MACF1 microtubule-actin crosslinking factor 1 0.0363734
APP amyloid beta (A4) precursor protein 0.0363702
ANKRD11 ankyrin repeat domain 11 0.036343
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0362429
PRKCE protein kinase C, epsilon 0.0361958
CDC73 cell division cycle 73 0.0361913
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0358137
RPS6 ribosomal protein S6 0.0355401
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0354231
NPAS2 neuronal PAS domain protein 2 0.0353224
YBX3 Y box binding protein 3 0.0351137
YTHDC1 YTH domain containing 1 0.0350605
UBE2K ubiquitin-conjugating enzyme E2K 0.0346399
ZMYM2 zinc finger, MYM-type 2 0.0346084
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0343951
JMJD1C jumonji domain containing 1C 0.0341445
PDPK1 3-phosphoinositide dependent protein kinase 1 0.0341082
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.034055
SEC23A Sec23 homolog A (S. cerevisiae) 0.0337955
CALD1 caldesmon 1 0.0337659
TPD52 tumor protein D52 0.0332096
WAC WW domain containing adaptor with coiled-coil 0.0331292
KIAA1958 KIAA1958 0.0329422
YBX1 Y box binding protein 1 0.0328291
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0328276
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.032585

decreased expression

Symbol Name Standardized Value
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0917322
FTL ferritin, light polypeptide -0.0907922
INTS6 integrator complex subunit 6 -0.0860296
STAU1 staufen double-stranded RNA binding protein 1 -0.0855722
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0814002
PRKCA protein kinase C, alpha -0.0730999
MAML2 mastermind-like 2 (Drosophila) -0.0730077
ATOSA atos homolog A -0.0700653
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0669165
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0658819
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0646333
MYO1E myosin IE -0.0644218
SRPK2 SRSF protein kinase 2 -0.0642014
RORA RAR-related orphan receptor A -0.0639956
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0639912
RPL35A ribosomal protein L35a -0.0635562
PDE4D phosphodiesterase 4D, cAMP-specific -0.0632575
SAMD4A sterile alpha motif domain containing 4A -0.0624149
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0619998
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0612951
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0612408
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0601937
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0601027
LMO7 LIM domain 7 -0.060067
WARS1 tryptophanyl-tRNA synthetase 1 -0.0589098
MAST4 microtubule associated serine/threonine kinase family member 4 -0.0576567
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0571573
IGFBP3 insulin-like growth factor binding protein 3 -0.0539705
S100A10 S100 calcium binding protein A10 -0.053909
LAMB3 laminin, beta 3 -0.0529197
LAMC2 laminin, gamma 2 -0.052553
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0523763
SLC38A1 solute carrier family 38, member 1 -0.0519581
TRA2A transformer 2 alpha homolog (Drosophila) -0.051157
KDM6A lysine (K)-specific demethylase 6A -0.050267
FAM107B family with sequence similarity 107, member B -0.0498233
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0494123
FBXO11 F-box protein 11 -0.0486366
DSCAM Down syndrome cell adhesion molecule -0.0484609
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0481474
TAOK3 TAO kinase 3 -0.0476624
GRAMD1B GRAM domain containing 1B -0.0475647
MUC16 mucin 16, cell surface associated -0.0473269
NALF1 NALCN channel auxiliary factor 1 -0.0470531
ARF1 ADP-ribosylation factor 1 -0.0468139
SHB Src homology 2 domain containing adaptor protein B -0.0466296
PTPRM protein tyrosine phosphatase, receptor type, M -0.0463738
RBM47 RNA binding motif protein 47 -0.0454877
CYTH1 cytohesin 1 -0.0451946
MAN2A1 mannosidase, alpha, class 2A, member 1 -0.0443401
CERS6 ceramide synthase 6 -0.0442875
ITGB4 integrin, beta 4 -0.0432776
TM9SF2 transmembrane 9 superfamily member 2 -0.0429176
IFRD1 interferon-related developmental regulator 1 -0.0427182
MBD4 methyl-CpG binding domain protein 4 -0.0419672
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 -0.0415963
FRMD5 FERM domain containing 5 -0.0412101
ZBTB20 zinc finger and BTB domain containing 20 -0.0412001
CD2AP CD2-associated protein -0.0410909
ZNF217 zinc finger protein 217 -0.040828
TM4SF1 transmembrane 4 L six family member 1 -0.0405167
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0405095
WSB1 WD repeat and SOCS box containing 1 -0.0404898
FNBP4 formin binding protein 4 -0.0404489
UFM1 ubiquitin-fold modifier 1 -0.0398592
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.0395466
SVIL supervillin -0.0395407
AFF1 AF4/FMR2 family, member 1 -0.0395237
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0394682
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -0.0394412
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0393724
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0390701
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6 -0.0387819
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0386828
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0382369
NABP1 nucleic acid binding protein 1 -0.0381562
PIBF1 progesterone immunomodulatory binding factor 1 -0.0381525
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0380321
TBCA tubulin folding cofactor A -0.0379228
SAMD9 sterile alpha motif domain containing 9 -0.0379056
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.037879
ERBB2 erb-b2 receptor tyrosine kinase 2 -0.0372863
COL11A1 collagen, type XI, alpha 1 -0.037237
AGFG1 ArfGAP with FG repeats 1 -0.0368671
RNF149 ring finger protein 149 -0.0366628
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0365196
MYL12B myosin, light chain 12B, regulatory -0.0363246
ZMYND8 zinc finger, MYND-type containing 8 -0.0363145
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0362908
FTH1 ferritin, heavy polypeptide 1 -0.0360918
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0360215
MBNL1 muscleblind-like splicing regulator 1 -0.0359165
CAPN2 calpain 2, (m/II) large subunit -0.0358982
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0358047
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.035605
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0355311
VMP1 vacuole membrane protein 1 -0.0354305
PLAUR plasminogen activator, urokinase receptor -0.0354222
MXD1 MAX dimerization protein 1 -0.035372
PERP PERP, TP53 apoptosis effector -0.0353705