| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pravastatin (sodium) perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pravastatin (sodium)_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0946316 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0824989 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0732889 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0591851 |
| RBM25 | RNA binding motif protein 25 | 0.0511882 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0504965 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0496177 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0482957 |
| SET | SET nuclear proto-oncogene | 0.0444988 |
| VIM | vimentin | 0.0441767 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0420776 |
| PNN | pinin, desmosome associated protein | 0.0410931 |
| TPI1 | triosephosphate isomerase 1 | 0.0396182 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.039431 |
| RPS12 | ribosomal protein S12 | 0.038626 |
| HDGF | hepatoma-derived growth factor | 0.0384893 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0381813 |
| MT2A | metallothionein 2A | 0.0377504 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0377021 |
| RPS3 | ribosomal protein S3 | 0.036882 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0362255 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0353613 |
| RPL37A | ribosomal protein L37a | 0.0343569 |
| RPL26 | ribosomal protein L26 | 0.0339441 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0332357 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0322317 |
| CBX3 | chromobox homolog 3 | 0.0321494 |
| PPIG | peptidylprolyl isomerase G (cyclophilin G) | 0.0317363 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.030801 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0296162 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0294644 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0293258 |
| YBX1 | Y box binding protein 1 | 0.0286413 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0280282 |
| RPS8 | ribosomal protein S8 | 0.0279959 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0279598 |
| RPS17 | ribosomal protein S17 | 0.027833 |
| RPS6 | ribosomal protein S6 | 0.0276298 |
| SMAP1 | small ArfGAP 1 | 0.0272664 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0271927 |
| RPS27 | ribosomal protein S27 | 0.0269249 |
| NCKAP1 | NCK-associated protein 1 | 0.0268914 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | 0.0259102 |
| PTMA | prothymosin, alpha | 0.0256016 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0253062 |
| PRELID2 | PRELI domain containing 2 | 0.0251104 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.0248556 |
| CEP192 | centrosomal protein 192kDa | 0.024774 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0246803 |
| FAM168A | family with sequence similarity 168, member A | 0.0242927 |
| TMEM14B | transmembrane protein 14B | 0.0242199 |
| PABPN1 | poly(A) binding protein, nuclear 1 | 0.0241105 |
| PCBP2 | poly(rC) binding protein 2 | 0.0238164 |
| AVL9 | AVL9 homolog (S. cerevisiase) | 0.0237665 |
| NUP58 | nucleoporin 58 | 0.023622 |
| RPL9 | ribosomal protein L9 | 0.023196 |
| CHD1L | chromodomain helicase DNA binding protein 1-like | 0.0230837 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0228868 |
| KIF5B | kinesin family member 5B | 0.0225108 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.0225073 |
| PPP1R21 | protein phosphatase 1, regulatory subunit 21 | 0.0224685 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0224566 |
| ZNF292 | zinc finger protein 292 | 0.0223789 |
| ATP5F1E | ATP synthase F1 subunit epsilon | 0.0222236 |
| RPS26 | ribosomal protein S26 | 0.0219436 |
| PPME1 | protein phosphatase methylesterase 1 | 0.0219029 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.0217541 |
| RPL27 | ribosomal protein L27 | 0.0216285 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | 0.0215125 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | 0.0214982 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.021497 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | 0.0210005 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | 0.0208996 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0208005 |
| LDHB | lactate dehydrogenase B | 0.0207863 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0207694 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | 0.0207409 |
| ARHGEF11 | Rho guanine nucleotide exchange factor (GEF) 11 | 0.0204205 |
| ANKRD36B | ankyrin repeat domain 36B | 0.0202163 |
| DNAJC21 | DnaJ (Hsp40) homolog, subfamily C, member 21 | 0.0201764 |
| BBX | bobby sox homolog (Drosophila) | 0.0199288 |
| RPL5 | ribosomal protein L5 | 0.0198982 |
| CASC3 | cancer susceptibility candidate 3 | 0.0198453 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | 0.0196623 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0195581 |
| TPM3 | tropomyosin 3 | 0.0192628 |
| RBM6 | RNA binding motif protein 6 | 0.0192378 |
| CENPF | centromere protein F, 350/400kDa | 0.0191918 |
| RPS21 | ribosomal protein S21 | 0.0191151 |
| FAM162A | family with sequence similarity 162, member A | 0.0190692 |
| NGLY1 | N-glycanase 1 | 0.0189464 |
| PFKP | phosphofructokinase, platelet | 0.0188385 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0188213 |
| RPS2 | ribosomal protein S2 | 0.0187491 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | 0.0187332 |
| TFDP2 | transcription factor Dp-2 (E2F dimerization partner 2) | 0.0186285 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0185871 |
| UBN2 | ubinuclein 2 | 0.0183974 |
| USP24 | ubiquitin specific peptidase 24 | 0.0183777 |
| EIF5AL1 | eukaryotic translation initiation factor 5A-like 1 | 0.018013 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.345477 |
| TXNRD1 | thioredoxin reductase 1 | -0.132762 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.115577 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.115172 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0973785 |
| EGR1 | early growth response 1 | -0.0873938 |
| ACTG1 | actin gamma 1 | -0.0866972 |
| UBC | ubiquitin C | -0.0853717 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0814824 |
| OSMR | oncostatin M receptor | -0.0799184 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0792605 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0729358 |
| VCL | vinculin | -0.0704876 |
| MCL1 | myeloid cell leukemia 1 | -0.0669828 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0628193 |
| PDE10A | phosphodiesterase 10A | -0.0612255 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0606972 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0603813 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.0598334 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0584114 |
| NABP1 | nucleic acid binding protein 1 | -0.0575097 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0562079 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0533669 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0531237 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0529329 |
| AHNAK | AHNAK nucleoprotein | -0.0513455 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0493609 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0487108 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0485136 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0482502 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0476072 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.047044 |
| GRAMD1B | GRAM domain containing 1B | -0.0469956 |
| NF1 | neurofibromin 1 | -0.0465552 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.046532 |
| ATF6 | activating transcription factor 6 | -0.0458476 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0454382 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0445451 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0442236 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.044109 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0436643 |
| FBXO11 | F-box protein 11 | -0.0433606 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0426648 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.042661 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0415058 |
| SPAG9 | sperm associated antigen 9 | -0.0414316 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0413795 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0408526 |
| CLTC | clathrin, heavy chain (Hc) | -0.0406134 |
| IER3 | immediate early response 3 | -0.0405553 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0403311 |
| FUS | FUS RNA binding protein | -0.0397145 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0393655 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -0.0391739 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0391733 |
| CDK12 | cyclin-dependent kinase 12 | -0.0390693 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0390558 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0385869 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0382858 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.0380477 |
| TMSB10 | thymosin beta 10 | -0.037524 |
| CDK17 | cyclin-dependent kinase 17 | -0.0363711 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0360933 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0355694 |
| CCND1 | cyclin D1 | -0.0355575 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0355571 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0346753 |
| INTS6 | integrator complex subunit 6 | -0.034363 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.034249 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0336671 |
| H1-0 | H1.0 linker histone | -0.0334502 |
| ADAR | adenosine deaminase, RNA-specific | -0.0332223 |
| MORF4L2 | mortality factor 4 like 2 | -0.0331894 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0331478 |
| KLF6 | Kruppel-like factor 6 | -0.0327059 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0324788 |
| PLSCR1 | phospholipid scramblase 1 | -0.0324242 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0324137 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.031538 |
| PRRC2B | proline-rich coiled-coil 2B | -0.0314244 |
| RBM39 | RNA binding motif protein 39 | -0.0313845 |
| RPS15 | ribosomal protein S15 | -0.0313784 |
| SNAP25 | synaptosomal-associated protein, 25kDa | -0.0306227 |
| RIGI | RNA sensor RIG-I | -0.0305262 |
| SETX | senataxin | -0.0304007 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0303598 |
| TMEM131 | transmembrane protein 131 | -0.0299592 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0299346 |
| YAP1 | Yes-associated protein 1 | -0.0297751 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0297569 |
| HDLBP | high density lipoprotein binding protein | -0.0297392 |
| JUN | jun proto-oncogene | -0.0294476 |
| RPL8 | ribosomal protein L8 | -0.0294158 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0292103 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0290391 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0290182 |
| CTTN | cortactin | -0.0287761 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0286965 |
| RAB10 | RAB10, member RAS oncogene family | -0.0284552 |
| PPP1R10 | protein phosphatase 1, regulatory subunit 10 | -0.0282968 |
