| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pravastatin (sodium) perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pravastatin (sodium)_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.155578 |
| ASPH | aspartate beta-hydroxylase | 0.149539 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.139198 |
| NDRG1 | N-myc downstream regulated 1 | 0.137346 |
| S100A6 | S100 calcium binding protein A6 | 0.113303 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.101444 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.09889 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0910124 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0894755 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0859673 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0795178 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0784817 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0667018 |
| RPS12 | ribosomal protein S12 | 0.0657046 |
| RACK1 | receptor for activated C kinase 1 | 0.0646373 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0605777 |
| MT2A | metallothionein 2A | 0.0552935 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0542317 |
| RPS3 | ribosomal protein S3 | 0.0538804 |
| SDC4 | syndecan 4 | 0.0526174 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0516836 |
| RPS19 | ribosomal protein S19 | 0.0513017 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0496627 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0484734 |
| RPL23 | ribosomal protein L23 | 0.0478469 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0470125 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0468781 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0467198 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0455269 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0449277 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0439284 |
| LAMB3 | laminin, beta 3 | 0.0437168 |
| CBX3 | chromobox homolog 3 | 0.0435174 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0435039 |
| TFG | TRK-fused gene | 0.0433231 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0420705 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0418485 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0410186 |
| TMSB4X | thymosin beta 4, X-linked | 0.040612 |
| DUSP6 | dual specificity phosphatase 6 | 0.0405381 |
| ARRDC3 | arrestin domain containing 3 | 0.0404504 |
| RPLP1 | ribosomal protein, large, P1 | 0.0401886 |
| RPL4 | ribosomal protein L4 | 0.0401179 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0398522 |
| GPX4 | glutathione peroxidase 4 | 0.0389966 |
| MSMO1 | methylsterol monooxygenase 1 | 0.0388218 |
| RNF145 | ring finger protein 145 | 0.0381867 |
| TMSB10 | thymosin beta 10 | 0.037792 |
| HMGB2 | high mobility group box 2 | 0.037677 |
| RPS17 | ribosomal protein S17 | 0.0370101 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.036849 |
| TXNRD1 | thioredoxin reductase 1 | 0.036788 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0361862 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0357075 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0354766 |
| RPL37A | ribosomal protein L37a | 0.0353536 |
| AREG | amphiregulin | 0.0351525 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0351354 |
| RPL26 | ribosomal protein L26 | 0.0348046 |
| MSN | moesin | 0.0344564 |
| RPL5 | ribosomal protein L5 | 0.033822 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0327678 |
| LDHA | lactate dehydrogenase A | 0.032754 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0325898 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0323718 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0316631 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0305588 |
| RPL18 | ribosomal protein L18 | 0.030532 |
| NCKAP1 | NCK-associated protein 1 | 0.0302407 |
| RPLP0 | ribosomal protein, large, P0 | 0.0301454 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0297464 |
| ANXA5 | annexin A5 | 0.0295322 |
| FAM162A | family with sequence similarity 162, member A | 0.0293951 |
| YBX1 | Y box binding protein 1 | 0.0290543 |
| RPL30 | ribosomal protein L30 | 0.0290012 |
| TOP1 | topoisomerase (DNA) I | 0.0288154 |
| RPS6 | ribosomal protein S6 | 0.0282674 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0281203 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.0279889 |
| RPS8 | ribosomal protein S8 | 0.0279854 |
| PCBP2 | poly(rC) binding protein 2 | 0.0277665 |
| CALR | calreticulin | 0.0277032 |
| AHNAK | AHNAK nucleoprotein | 0.0275143 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0274627 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | 0.0270771 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0268983 |
| SQSTM1 | sequestosome 1 | 0.0268706 |
| RPL32 | ribosomal protein L32 | 0.0267894 |
| NUP58 | nucleoporin 58 | 0.0264678 |
| FAM3C | family with sequence similarity 3, member C | 0.0263816 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0262905 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0262279 |
| SEPTIN7 | septin 7 | 0.0259716 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0256133 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | 0.0255558 |
| MIER1 | mesoderm induction early response 1, transcriptional regulator | 0.0252155 |
| RPS4X | ribosomal protein S4, X-linked | 0.024729 |
| CCNL1 | cyclin L1 | 0.024677 |
| TUBA1B | tubulin, alpha 1b | 0.0241459 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0237939 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ACTG1 | actin gamma 1 | -0.156903 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.107588 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0912211 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.089113 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0849842 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0819163 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0766353 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0766328 |
| RAB7A | RAB7A, member RAS oncogene family | -0.073114 |
| FBXO32 | F-box protein 32 | -0.0685062 |
| ERBIN | erbb2 interacting protein | -0.0674376 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0549018 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0538838 |
| GOLGB1 | golgin B1 | -0.052301 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0514596 |
| MAP3K13 | mitogen-activated protein kinase kinase kinase 13 | -0.0493523 |
| HLA-A | major histocompatibility complex, class I, A | -0.0492746 |
| MYO1E | myosin IE | -0.0484069 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0481013 |
| CCND1 | cyclin D1 | -0.0475312 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0474293 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0468741 |
| FBXO11 | F-box protein 11 | -0.0457439 |
| POTEF | POTE ankyrin domain family, member F | -0.0453373 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0452615 |
| MCU | mitochondrial calcium uniporter | -0.0447867 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.0443025 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.042873 |
| PTMA | prothymosin, alpha | -0.0425577 |
| TPM4 | tropomyosin 4 | -0.0425529 |
| FTL | ferritin, light polypeptide | -0.0419638 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.041597 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0411821 |
| WASF2 | WAS protein family, member 2 | -0.0410841 |
| VCL | vinculin | -0.0407858 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0404766 |
| FNIP1 | folliculin interacting protein 1 | -0.0400926 |
| EFNA5 | ephrin-A5 | -0.0392399 |
| HLA-B | major histocompatibility complex, class I, B | -0.0380331 |
| SETD5 | SET domain containing 5 | -0.0380072 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0373324 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0369917 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0363135 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0362151 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0355301 |
| PPP1R13B | protein phosphatase 1, regulatory subunit 13B | -0.0354467 |
| CEP350 | centrosomal protein 350kDa | -0.035406 |
| MAP4 | microtubule-associated protein 4 | -0.0353867 |
| RAI14 | retinoic acid induced 14 | -0.0343748 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0342325 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0340089 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0339993 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0336054 |
| RASAL2 | RAS protein activator like 2 | -0.0333544 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.033218 |
| RNF213 | ring finger protein 213 | -0.0331686 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0328868 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0328448 |
| KLHL24 | kelch-like family member 24 | -0.0328277 |
| JMJD1C | jumonji domain containing 1C | -0.0326412 |
| MX2 | MX dynamin-like GTPase 2 | -0.0321557 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0321261 |
| CDK13 | cyclin-dependent kinase 13 | -0.0316109 |
| ANXA2 | annexin A2 | -0.0315571 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0315525 |
| PPP2R3A | protein phosphatase 2, regulatory subunit B'', alpha | -0.0315021 |
| AOPEP | aminopeptidase O (putative) | -0.0313912 |
| ARHGAP20 | Rho GTPase activating protein 20 | -0.0311437 |
| ATOSA | atos homolog A | -0.031045 |
| PALLD | palladin, cytoskeletal associated protein | -0.0309709 |
| FN1 | fibronectin 1 | -0.0309572 |
| HDLBP | high density lipoprotein binding protein | -0.0307201 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0306888 |
| RAB5A | RAB5A, member RAS oncogene family | -0.0306411 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0305425 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0300953 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0300395 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0299609 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0299201 |
| NF1 | neurofibromin 1 | -0.0298076 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0296958 |
| ARF1 | ADP-ribosylation factor 1 | -0.0294994 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0293538 |
| FBXL2 | F-box and leucine-rich repeat protein 2 | -0.0293462 |
| FBXO34 | F-box protein 34 | -0.0290814 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0289834 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0288094 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0287773 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0285773 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0285357 |
| FNBP4 | formin binding protein 4 | -0.0281424 |
| AFF1 | AF4/FMR2 family, member 1 | -0.0279193 |
| ARHGEF3 | Rho guanine nucleotide exchange factor (GEF) 3 | -0.0278251 |
| YY1 | YY1 transcription factor | -0.0277506 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.027672 |
| CTSB | cathepsin B | -0.027458 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0271984 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0271745 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0269421 |
| RBM39 | RNA binding motif protein 39 | -0.026763 |
