| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pravastatin (sodium) perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pravastatin (sodium)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.143973 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.119974 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.119217 |
| EFNA5 | ephrin-A5 | 0.0962249 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0958559 |
| PCBP2 | poly(rC) binding protein 2 | 0.0913763 |
| PTMA | prothymosin, alpha | 0.0901192 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.086682 |
| RPS12 | ribosomal protein S12 | 0.0745824 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0721768 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.069526 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | 0.0602807 |
| VIM | vimentin | 0.0601539 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0584615 |
| S100A6 | S100 calcium binding protein A6 | 0.0583484 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0582073 |
| ASPH | aspartate beta-hydroxylase | 0.0575395 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0573303 |
| MCL1 | myeloid cell leukemia 1 | 0.0570991 |
| FAM13A | family with sequence similarity 13, member A | 0.0563336 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0558506 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0551479 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0544523 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0544452 |
| SET | SET nuclear proto-oncogene | 0.0543967 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.053358 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0532907 |
| OGA | O-GlcNAcase | 0.0517494 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0510042 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0506703 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0493879 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0490581 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0489681 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0486179 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0475978 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0473302 |
| RPL26 | ribosomal protein L26 | 0.0469376 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0465525 |
| AHNAK | AHNAK nucleoprotein | 0.0461569 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0457654 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.044709 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0438837 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0431302 |
| DNER | delta/notch-like EGF repeat containing | 0.043026 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0418618 |
| ATP13A3 | ATPase type 13A3 | 0.0415016 |
| RPS3 | ribosomal protein S3 | 0.0413991 |
| PCBP3 | poly(rC) binding protein 3 | 0.0413185 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0410115 |
| RBM25 | RNA binding motif protein 25 | 0.0402368 |
| PDGFA | platelet-derived growth factor alpha polypeptide | 0.0401829 |
| SPAG9 | sperm associated antigen 9 | 0.0398588 |
| ZNF292 | zinc finger protein 292 | 0.0395182 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | 0.0394244 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0393938 |
| RPL3 | ribosomal protein L3 | 0.0393101 |
| HDGF | hepatoma-derived growth factor | 0.0390963 |
| FMNL2 | formin-like 2 | 0.0390887 |
| RPL4 | ribosomal protein L4 | 0.0389354 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0384516 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0382342 |
| STC1 | stanniocalcin 1 | 0.0381377 |
| RNF145 | ring finger protein 145 | 0.0380916 |
| COL4A6 | collagen, type IV, alpha 6 | 0.0361154 |
| CHD1L | chromodomain helicase DNA binding protein 1-like | 0.0358051 |
| CTSC | cathepsin C | 0.0355484 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0352788 |
| RPL37A | ribosomal protein L37a | 0.034473 |
| COPA | coatomer protein complex, subunit alpha | 0.0334297 |
| RPS8 | ribosomal protein S8 | 0.0331141 |
| USP34 | ubiquitin specific peptidase 34 | 0.0325993 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0324876 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0323918 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0323698 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0320255 |
| LMNA | lamin A/C | 0.0316438 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.031028 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0309561 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0309477 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0306415 |
| NCKAP1 | NCK-associated protein 1 | 0.0304976 |
| TOP1 | topoisomerase (DNA) I | 0.0304012 |
| TPM3 | tropomyosin 3 | 0.0302737 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0302236 |
| FUT11 | fucosyltransferase 11 (alpha (1,3) fucosyltransferase) | 0.0300192 |
| CTBP2 | C-terminal binding protein 2 | 0.0298356 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0296454 |
| THOC2 | THO complex 2 | 0.0295153 |
| FLNB | filamin B, beta | 0.0294548 |
| RAI1 | retinoic acid induced 1 | 0.029369 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.029314 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0290931 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.028977 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.0288694 |
| GOLGA4 | golgin A4 | 0.0288582 |
| PTEN | phosphatase and tensin homolog | 0.0274925 |
| MYOF | myoferlin | 0.0266578 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0260925 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0260759 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0259816 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.390299 |
| FN1 | fibronectin 1 | -0.146113 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.141391 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.116811 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.0995752 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0913903 |
| TXNRD1 | thioredoxin reductase 1 | -0.0912951 |
| TMSB10 | thymosin beta 10 | -0.0897978 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0896738 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0783286 |
| RPLP1 | ribosomal protein, large, P1 | -0.0719997 |
| FTL | ferritin, light polypeptide | -0.0715482 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.062677 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0564053 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0553063 |
| RPS24 | ribosomal protein S24 | -0.0536492 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0508258 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0486721 |
| RPL35A | ribosomal protein L35a | -0.0483367 |
| GDA | guanine deaminase | -0.0481417 |
| RPS23 | ribosomal protein S23 | -0.0471101 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0452995 |
| PM20D1 | peptidase M20 domain containing 1 | -0.0452662 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0440419 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.0396374 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0387427 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0370055 |
| EGR1 | early growth response 1 | -0.0353051 |
| OSMR | oncostatin M receptor | -0.0340506 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0336313 |
| RPL34 | ribosomal protein L34 | -0.0334134 |
| RPLP0 | ribosomal protein, large, P0 | -0.0326039 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.030991 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0305829 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.030455 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0304462 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.03044 |
| RPS19 | ribosomal protein S19 | -0.0300675 |
| ACTG1 | actin gamma 1 | -0.0297671 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0274907 |
| VCL | vinculin | -0.0273476 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0272533 |
| RPL19 | ribosomal protein L19 | -0.0271222 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0268685 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.0267096 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0265091 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.026103 |
| PDE10A | phosphodiesterase 10A | -0.0252318 |
| RPL32 | ribosomal protein L32 | -0.0242627 |
| TUSC3 | tumor suppressor candidate 3 | -0.0241912 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0235153 |
| ARF1 | ADP-ribosylation factor 1 | -0.0235074 |
| RPS15 | ribosomal protein S15 | -0.0233824 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.0233287 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | -0.0232891 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0232234 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0226349 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0224684 |
| RHOB | ras homolog family member B | -0.0215486 |
| AGTPBP1 | ATP/GTP binding protein 1 | -0.0211676 |
| RPS5 | ribosomal protein S5 | -0.0211384 |
| CADM2 | cell adhesion molecule 2 | -0.0210439 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0207678 |
| GNAS | GNAS complex locus | -0.0205594 |
| BSG | basigin (Ok blood group) | -0.02055 |
| CCL5 | chemokine (C-C motif) ligand 5 | -0.0205267 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0201321 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0195793 |
| RPL38 | ribosomal protein L38 | -0.0188368 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0187335 |
| HMGB1 | high mobility group box 1 | -0.0186638 |
| EPHA5 | EPH receptor A5 | -0.0185602 |
| NTN4 | netrin 4 | -0.018486 |
| PDE1A | phosphodiesterase 1A, calmodulin-dependent | -0.0184746 |
| PKM | pyruvate kinase, muscle | -0.0184031 |
| MT2A | metallothionein 2A | -0.0183884 |
| CDK12 | cyclin-dependent kinase 12 | -0.018355 |
| KIAA0825 | KIAA0825 | -0.0182675 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0181265 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0180015 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0178657 |
| RPS21 | ribosomal protein S21 | -0.0176042 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0175015 |
| EXOC6B | exocyst complex component 6B | -0.0173878 |
| KYNU | kynureninase | -0.0173348 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0172104 |
| RPL8 | ribosomal protein L8 | -0.0171265 |
| RAB7A | RAB7A, member RAS oncogene family | -0.017001 |
| RPL7A | ribosomal protein L7a | -0.0169947 |
| COL5A2 | collagen, type V, alpha 2 | -0.0163486 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | -0.0163405 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0163105 |
| LAMA1 | laminin, alpha 1 | -0.0162913 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | -0.0162469 |
| ANXA2 | annexin A2 | -0.0161592 |
| NABP1 | nucleic acid binding protein 1 | -0.0159713 |
| TNPO1 | transportin 1 | -0.015857 |
| LPGAT1 | lysophosphatidylglycerol acyltransferase 1 | -0.0158083 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0156793 |
| MAP1B | microtubule-associated protein 1B | -0.0156278 |
