| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pravastatin (sodium) perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pravastatin (sodium)_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.206986 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.116217 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0986064 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0979838 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0885737 |
| HDAC9 | histone deacetylase 9 | 0.0857649 |
| RPS12 | ribosomal protein S12 | 0.0682669 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0664266 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0663868 |
| POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | 0.0641856 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0640997 |
| ZNF292 | zinc finger protein 292 | 0.0627832 |
| PGAP1 | post-GPI attachment to proteins 1 | 0.0613001 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0578231 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0564065 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0556371 |
| PCBP2 | poly(rC) binding protein 2 | 0.0549922 |
| PTMA | prothymosin, alpha | 0.0534749 |
| PDS5B | PDS5 cohesin associated factor B | 0.0519405 |
| NCKAP1 | NCK-associated protein 1 | 0.0500738 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0489889 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0483845 |
| TPM3 | tropomyosin 3 | 0.0482799 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0462971 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0462529 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0460787 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0458462 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 0.0458052 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0451367 |
| SET | SET nuclear proto-oncogene | 0.0450985 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0450077 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0449037 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | 0.0444577 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0444053 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0442506 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.0436553 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0436408 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0426913 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.042375 |
| CFL2 | cofilin 2 (muscle) | 0.0423393 |
| CCNL1 | cyclin L1 | 0.0415483 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0411336 |
| CDC73 | cell division cycle 73 | 0.0410489 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.040836 |
| DST | dystonin | 0.040395 |
| RAI1 | retinoic acid induced 1 | 0.0399805 |
| RREB1 | ras responsive element binding protein 1 | 0.039827 |
| WDR43 | WD repeat domain 43 | 0.0394275 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.038867 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0385627 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0377914 |
| B2M | beta-2-microglobulin | 0.0367824 |
| RASAL2 | RAS protein activator like 2 | 0.0367465 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0367006 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0366949 |
| LRRC4C | leucine rich repeat containing 4C | 0.0366017 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0363533 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0363064 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0362186 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | 0.0360288 |
| RPL9 | ribosomal protein L9 | 0.0359257 |
| RBM33 | RNA binding motif protein 33 | 0.0356226 |
| VIM | vimentin | 0.0353985 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0352608 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0350664 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0347682 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0345313 |
| ENAH | enabled homolog (Drosophila) | 0.0343739 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0343485 |
| MEMO1 | mediator of cell motility 1 | 0.0343477 |
| NTM | neurotrimin | 0.0336131 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0335229 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0332976 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0332827 |
| LHFPL6 | LHFPL tetraspan subfamily member 6 | 0.0330616 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0329574 |
| SPAG9 | sperm associated antigen 9 | 0.032943 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | 0.0328555 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.0326373 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0325113 |
| FNBP4 | formin binding protein 4 | 0.0323941 |
| MYO10 | myosin X | 0.0322752 |
| TCEA1 | transcription elongation factor A (SII), 1 | 0.0312453 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0308992 |
| MED13L | mediator complex subunit 13-like | 0.0307828 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0306972 |
| SOX5 | SRY (sex determining region Y)-box 5 | 0.0305291 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0304389 |
| SBF2 | SET binding factor 2 | 0.0302026 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | 0.0298966 |
| ANXA1 | annexin A1 | 0.0298539 |
| RPL37A | ribosomal protein L37a | 0.0297243 |
| SNX6 | sorting nexin 6 | 0.0296573 |
| MYOF | myoferlin | 0.0293056 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0291935 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0285961 |
| GALNTL6 | polypeptide N-acetylgalactosaminyltransferase-like 6 | 0.0284861 |
| MIER1 | mesoderm induction early response 1, transcriptional regulator | 0.0282616 |
| RPS2 | ribosomal protein S2 | 0.0280693 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | 0.0280406 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.161448 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.116888 |
| TMSB10 | thymosin beta 10 | -0.0994784 |
| ACTG1 | actin gamma 1 | -0.0908677 |
| CADM2 | cell adhesion molecule 2 | -0.0734231 |
| RPS16 | ribosomal protein S16 | -0.0654385 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.057763 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | -0.0549827 |
| RPLP1 | ribosomal protein, large, P1 | -0.0537338 |
| MEIS2 | Meis homeobox 2 | -0.0510138 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | -0.0506835 |
| ACTN4 | actinin, alpha 4 | -0.0485081 |
| PHIP | pleckstrin homology domain interacting protein | -0.0481701 |
| FBL | fibrillarin | -0.0465367 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0462446 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0446515 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0431493 |
| EMP1 | epithelial membrane protein 1 | -0.042283 |
| GPC3 | glypican 3 | -0.0422141 |
| SEMA3D | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D | -0.041528 |
| MKI67 | marker of proliferation Ki-67 | -0.0401302 |
| FOXP2 | forkhead box P2 | -0.0395353 |
| RAD51B | RAD51 paralog B | -0.0393582 |
| HMGB1 | high mobility group box 1 | -0.0392715 |
| RPL34 | ribosomal protein L34 | -0.0391389 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.0385582 |
| CLTC | clathrin, heavy chain (Hc) | -0.0383807 |
| UBB | ubiquitin B | -0.0381604 |
| RPL19 | ribosomal protein L19 | -0.0381044 |
| CKAP2 | cytoskeleton associated protein 2 | -0.0377574 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0374094 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0369352 |
| FAM171B | family with sequence similarity 171, member B | -0.0368797 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | -0.0363886 |
| R3HDM1 | R3H domain containing 1 | -0.0357711 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0354086 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.0348594 |
| RPS4X | ribosomal protein S4, X-linked | -0.0343252 |
| RPS19 | ribosomal protein S19 | -0.0330727 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0330494 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0328862 |
| FSCN1 | fascin actin-bundling protein 1 | -0.0327314 |
| RPL38 | ribosomal protein L38 | -0.0317638 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.031688 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.0312001 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0311143 |
| PHF21A | PHD finger protein 21A | -0.0307665 |
| RPL36A | ribosomal protein L36a | -0.0307357 |
| RPL35A | ribosomal protein L35a | -0.0306132 |
| MAP4K3 | mitogen-activated protein kinase kinase kinase kinase 3 | -0.0305554 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.030314 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0295436 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0294436 |
| STAG2 | stromal antigen 2 | -0.0293748 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.029019 |
| HMGB2 | high mobility group box 2 | -0.0286876 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.02842 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0283588 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0282336 |
| RBBP6 | retinoblastoma binding protein 6 | -0.0281565 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.0279309 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0277416 |
| GLG1 | golgi glycoprotein 1 | -0.0276733 |
| CALM3 | calmodulin 3 (phosphorylase kinase, delta) | -0.0274177 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0270929 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0270271 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | -0.027 |
| CENPE | centromere protein E, 312kDa | -0.0269738 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0268749 |
| NUSAP1 | nucleolar and spindle associated protein 1 | -0.0267956 |
| ATF4 | activating transcription factor 4 | -0.026778 |
| LRCH3 | leucine-rich repeats and calponin homology (CH) domain containing 3 | -0.0265759 |
| HS3ST5 | heparan sulfate (glucosamine) 3-O-sulfotransferase 5 | -0.0263498 |
| LTN1 | listerin E3 ubiquitin protein ligase 1 | -0.0262455 |
| RPS5 | ribosomal protein S5 | -0.0261664 |
| MAP4 | microtubule-associated protein 4 | -0.0261169 |
| BAZ2A | bromodomain adjacent to zinc finger domain, 2A | -0.0260563 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0257942 |
| PFN1 | profilin 1 | -0.0257588 |
| RPL7 | ribosomal protein L7 | -0.0257255 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | -0.0255314 |
| LATS2 | large tumor suppressor kinase 2 | -0.0249508 |
| ECH1 | enoyl CoA hydratase 1, peroxisomal | -0.0249205 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0247475 |
| GNS | glucosamine (N-acetyl)-6-sulfatase | -0.024502 |
| ZMYM4 | zinc finger, MYM-type 4 | -0.0244445 |
| ZNF644 | zinc finger protein 644 | -0.0244204 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0243866 |
| ANXA2 | annexin A2 | -0.0243312 |
| EPHA5 | EPH receptor A5 | -0.0243045 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0241913 |
| STK4 | serine/threonine kinase 4 | -0.0241473 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0239381 |
| SLC25A6 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 | -0.0239079 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0238707 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | -0.0238665 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -0.0238204 |
| KLHL24 | kelch-like family member 24 | -0.0236597 |
| WASL | Wiskott-Aldrich syndrome-like | -0.0235747 |
| TWSG1 | twisted gastrulation BMP signaling modulator 1 | -0.0235716 |
