Pravastatin (sodium)_Panc 03.27 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pravastatin (sodium) perturbation in Panc 03.27 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Pravastatin (sodium)_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LAMB3 laminin, beta 3 0.177782
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.155832
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.089068
AHNAK AHNAK nucleoprotein 0.0885953
KRT17 keratin 17, type I 0.0850271
FAM3C family with sequence similarity 3, member C 0.0746354
EZR ezrin 0.0742048
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0670656
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0669671
GOLGA4 golgin A4 0.0666015
PCBP2 poly(rC) binding protein 2 0.065663
PRRC2C proline-rich coiled-coil 2C 0.0655663
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0606827
XPO1 exportin 1 0.060606
RBM25 RNA binding motif protein 25 0.0601169
OGA O-GlcNAcase 0.058703
SMC4 structural maintenance of chromosomes 4 0.0575375
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0563339
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0557655
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0539157
NPEPPS aminopeptidase puromycin sensitive 0.0515518
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0508382
CKAP5 cytoskeleton associated protein 5 0.049984
ARHGAP29 Rho GTPase activating protein 29 0.0486904
UGCG UDP-glucose ceramide glucosyltransferase 0.0479825
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.046083
ECT2 epithelial cell transforming 2 0.0447909
RPS3 ribosomal protein S3 0.0447415
NRIP1 nuclear receptor interacting protein 1 0.0443562
TOP1 topoisomerase (DNA) I 0.0437092
PTMA prothymosin, alpha 0.0431077
SLTM SAFB-like, transcription modulator 0.0429516
MYO6 myosin VI 0.0424376
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0412683
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0408667
S100A6 S100 calcium binding protein A6 0.0407421
DDIT4 DNA-damage-inducible transcript 4 0.0401959
ANLN anillin, actin binding protein 0.039777
DIAPH3 diaphanous-related formin 3 0.0396638
KTN1 kinectin 1 (kinesin receptor) 0.0395714
RIOK3 RIO kinase 3 0.0389238
HMGB2 high mobility group box 2 0.0388619
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.038586
CENPF centromere protein F, 350/400kDa 0.0385261
ERRFI1 ERBB receptor feedback inhibitor 1 0.0380036
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0378805
KRT8 keratin 8, type II 0.0375454
MKI67 marker of proliferation Ki-67 0.0372889
RTN4 reticulon 4 0.0369619
JMJD1C jumonji domain containing 1C 0.0367094
FOSL1 FOS-like antigen 1 0.0366655
CTNND1 catenin (cadherin-associated protein), delta 1 0.0344427
LDHA lactate dehydrogenase A 0.0341436
MBNL2 muscleblind-like splicing regulator 2 0.0335887
RPL18 ribosomal protein L18 0.0334717
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.033397
KRT18 keratin 18, type I 0.0333861
UBA6 ubiquitin-like modifier activating enzyme 6 0.0323018
CDC27 cell division cycle 27 0.0320182
TPR translocated promoter region, nuclear basket protein 0.0315893
NAMPT nicotinamide phosphoribosyltransferase 0.0312375
APLP2 amyloid beta (A4) precursor-like protein 2 0.0309989
BZW1 basic leucine zipper and W2 domains 1 0.0309325
B2M beta-2-microglobulin 0.030617
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0305929
MATR3 matrin 3 0.0304114
IRS2 insulin receptor substrate 2 0.0304022
MYH9 myosin, heavy chain 9, non-muscle 0.0302521
PCLO piccolo presynaptic cytomatrix protein 0.0300433
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0299326
CD47 CD47 molecule 0.0298191
NDRG1 N-myc downstream regulated 1 0.0296752
NAV2 neuron navigator 2 0.0293637
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0293484
EPCAM epithelial cell adhesion molecule 0.0293092
MT2A metallothionein 2A 0.0292217
ITCH itchy E3 ubiquitin protein ligase 0.0291108
PGK1 phosphoglycerate kinase 1 0.0288055
MYOF myoferlin 0.0283998
KDM3A lysine (K)-specific demethylase 3A 0.0282023
PTBP3 polypyrimidine tract binding protein 3 0.0281118
RNF149 ring finger protein 149 0.0280135
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0279965
ATP13A3 ATPase type 13A3 0.027914
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0276281
ELP2 elongator acetyltransferase complex subunit 2 0.0272688
SEPTIN7 septin 7 0.0272253
CBX3 chromobox homolog 3 0.0271727
CD46 CD46 molecule, complement regulatory protein 0.0271564
THOC2 THO complex 2 0.0268582
CANX calnexin 0.0265518
RLF rearranged L-myc fusion 0.0265377
CCNY cyclin Y 0.0265168
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0264546
RNF145 ring finger protein 145 0.0264545
ZFP36L1 ZFP36 ring finger protein-like 1 0.0264425
ADAM9 ADAM metallopeptidase domain 9 0.0263413
SKAP2 src kinase associated phosphoprotein 2 0.0260611
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0258213
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) 0.0257586

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.159664
LMO7 LIM domain 7 -0.157491
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.123132
ACTG1 actin gamma 1 -0.116502
MUC4 mucin 4, cell surface associated -0.114307
FN1 fibronectin 1 -0.111804
INTS6 integrator complex subunit 6 -0.108656
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0958045
IGFBP3 insulin-like growth factor binding protein 3 -0.0870649
FTH1 ferritin, heavy polypeptide 1 -0.0807089
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.077624
MYO1E myosin IE -0.0768691
FTL ferritin, light polypeptide -0.073934
MUC16 mucin 16, cell surface associated -0.0714327
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0703819
RNF213 ring finger protein 213 -0.0685824
RPL35A ribosomal protein L35a -0.0681396
F3 coagulation factor III (thromboplastin, tissue factor) -0.064602
SVIL supervillin -0.0641991
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0631275
TJP1 tight junction protein 1 -0.0626789
ZBTB20 zinc finger and BTB domain containing 20 -0.0611903
HMGA1 high mobility group AT-hook 1 -0.0610176
MX1 MX dynamin-like GTPase 1 -0.060973
RAB7A RAB7A, member RAS oncogene family -0.0595239
SYT14 synaptotagmin XIV -0.0561974
PLSCR1 phospholipid scramblase 1 -0.0553055
MX2 MX dynamin-like GTPase 2 -0.0544533
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 -0.0529127
HLA-B major histocompatibility complex, class I, B -0.0490297
SULF2 sulfatase 2 -0.0483444
RPS23 ribosomal protein S23 -0.0479189
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0472945
RIGI RNA sensor RIG-I -0.0470903
RPL31 ribosomal protein L31 -0.0469339
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0465619
RCOR1 REST corepressor 1 -0.0461992
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0461036
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.0460887
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0458745
CD44 CD44 molecule (Indian blood group) -0.0455257
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0454183
GOLGB1 golgin B1 -0.0437484
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0435252
KLF5 Kruppel-like factor 5 (intestinal) -0.0419554
ERBIN erbb2 interacting protein -0.0412857
SLCO3A1 solute carrier organic anion transporter family, member 3A1 -0.0400676
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 -0.0398081
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0389294
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -0.038828
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0381209
EPSTI1 epithelial stromal interaction 1 (breast) -0.0380977
EGR1 early growth response 1 -0.0380113
ZDHHC13 zinc finger, DHHC-type containing 13 -0.0377695
SQSTM1 sequestosome 1 -0.036913
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0368853
SH3KBP1 SH3-domain kinase binding protein 1 -0.0367925
OXSR1 oxidative stress responsive 1 -0.0366696
SP100 SP100 nuclear antigen -0.0365612
RPS10 ribosomal protein S10 -0.03653
JARID2 jumonji, AT rich interactive domain 2 -0.0360331
SOX4 SRY (sex determining region Y)-box 4 -0.0360229
RPS15 ribosomal protein S15 -0.0356806
RPS13 ribosomal protein S13 -0.0355851
ETV6 ets variant 6 -0.0348245
VEGFA vascular endothelial growth factor A -0.0344573
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0343417
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0342035
TPM4 tropomyosin 4 -0.0341239
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0339642
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0335724
MAML2 mastermind-like 2 (Drosophila) -0.0335214
HDAC9 histone deacetylase 9 -0.0333962
LOC102724023 ES1 protein homolog, mitochondrial -0.033009
IFI27 interferon, alpha-inducible protein 27 -0.0319468
KYNU kynureninase -0.0318543
C3 complement component 3 -0.0318205
WFDC2 WAP four-disulfide core domain 2 -0.031806
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0317912
RSAD2 radical S-adenosyl methionine domain containing 2 -0.031506
DTX3L deltex 3 like, E3 ubiquitin ligase -0.0312791
HLA-C major histocompatibility complex, class I, C -0.0312461
SORBS2 sorbin and SH3 domain containing 2 -0.0310082
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0308148
VCL vinculin -0.0306949
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0306525
PDLIM5 PDZ and LIM domain 5 -0.030259
EXT1 exostosin glycosyltransferase 1 -0.0301026
ZHX2 zinc fingers and homeoboxes 2 -0.0300703
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -0.0300606
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0300301
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0296897
PATJ PATJ crumbs cell polarity complex component -0.0296469
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0295218
SIK3 SIK family kinase 3 -0.0294866
EGFR epidermal growth factor receptor -0.0292647
RPS29 ribosomal protein S29 -0.0292249
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0290854
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0290232
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.02889