Pravastatin (sodium)_SHP-77 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pravastatin (sodium) perturbation in SHP-77 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pravastatin (sodium)_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0928039
NDRG1 N-myc downstream regulated 1 0.0842399
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0804597
ZNF292 zinc finger protein 292 0.0713433
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0701568
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0675287
GRB10 growth factor receptor-bound protein 10 0.0607123
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0580931
CENPF centromere protein F, 350/400kDa 0.0572006
FAM13A family with sequence similarity 13, member A 0.0558232
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0541479
HMGB3 high mobility group box 3 0.0505886
CHD7 chromodomain helicase DNA binding protein 7 0.0497707
NUP58 nucleoporin 58 0.0479373
DTNA dystrobrevin, alpha 0.046924
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0467002
CA8 carbonic anhydrase VIII 0.0450162
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0422598
KTN1 kinectin 1 (kinesin receptor) 0.0415894
PDIA6 protein disulfide isomerase family A, member 6 0.0406215
PGK1 phosphoglycerate kinase 1 0.0389177
SET SET nuclear proto-oncogene 0.0382876
MYH9 myosin, heavy chain 9, non-muscle 0.0380345
PIAS2 protein inhibitor of activated STAT, 2 0.0376271
SMC1A structural maintenance of chromosomes 1A 0.0372653
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0372081
PEG10 paternally expressed 10 0.036945
ECT2 epithelial cell transforming 2 0.0356715
WDR45B WD repeat domain 45B 0.0356635
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0352722
TPD52 tumor protein D52 0.0349925
CKAP5 cytoskeleton associated protein 5 0.0347634
PPME1 protein phosphatase methylesterase 1 0.0326641
IGFBP5 insulin-like growth factor binding protein 5 0.0319973
ERRFI1 ERBB receptor feedback inhibitor 1 0.0314332
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0314075
SFPQ splicing factor proline/glutamine-rich 0.0312067
TPM3 tropomyosin 3 0.0305563
TPX2 TPX2, microtubule-associated 0.0305498
VEGFA vascular endothelial growth factor A 0.0305343
XPO1 exportin 1 0.0300403
ZNF395 zinc finger protein 395 0.0289527
KMT2E lysine (K)-specific methyltransferase 2E 0.0286549
UBA6 ubiquitin-like modifier activating enzyme 6 0.028212
CADM1 cell adhesion molecule 1 0.0277822
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0276626
MXI1 MAX interactor 1, dimerization protein 0.0276231
CCNY cyclin Y 0.0274599
AFF1 AF4/FMR2 family, member 1 0.0273279
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0272141
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0269787
CDK5RAP2 CDK5 regulatory subunit associated protein 2 0.0265137
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 0.0264282
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0264246
LMNB1 lamin B1 0.0260805
APLP2 amyloid beta (A4) precursor-like protein 2 0.0260094
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0259459
HDGF hepatoma-derived growth factor 0.0257779
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0254665
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.025366
MSI2 musashi RNA-binding protein 2 0.0252712
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0250096
NCKAP1 NCK-associated protein 1 0.0249919
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0249725
YY1AP1 YY1 associated protein 1 0.0249239
NBAS neuroblastoma amplified sequence 0.0246451
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0245561
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0241854
DENND1A DENN/MADD domain containing 1A 0.0238689
TRIO trio Rho guanine nucleotide exchange factor 0.0235214
SERBP1 SERPINE1 mRNA binding protein 1 0.0234725
PCBP2 poly(rC) binding protein 2 0.023336
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 0.0232907
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0230542
LCORL ligand dependent nuclear receptor corepressor-like 0.0228179
ASCL1 achaete-scute family bHLH transcription factor 1 0.0228165
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0227815
PDS5B PDS5 cohesin associated factor B 0.0227479
DGKD diacylglycerol kinase, delta 130kDa 0.0227188
SPAG5 sperm associated antigen 5 0.022391
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0222414
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.022116
RNF145 ring finger protein 145 0.0220132
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0220061
EYA2 EYA transcriptional coactivator and phosphatase 2 0.0219358
LIFR leukemia inhibitory factor receptor alpha 0.0218596
RPS12 ribosomal protein S12 0.021786
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0217773
JAM3 junctional adhesion molecule 3 0.021717
PGAP1 post-GPI attachment to proteins 1 0.0217133
NAP1L1 nucleosome assembly protein 1-like 1 0.021709
G2E3 G2/M-phase specific E3 ubiquitin protein ligase 0.0216294
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.0214646
AURKA aurora kinase A 0.0214575
MBNL2 muscleblind-like splicing regulator 2 0.0211741
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0211621
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0210326
MSN moesin 0.0208769
YTHDC1 YTH domain containing 1 0.0208304
ELAVL2 ELAV like neuron-specific RNA binding protein 2 0.0207444

decreased expression

Symbol Name Standardized Value
PDE10A phosphodiesterase 10A -0.223871
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.132413
RIMS2 regulating synaptic membrane exocytosis 2 -0.105121
GRIK1 glutamate receptor, ionotropic, kainate 1 -0.0887557
FTL ferritin, light polypeptide -0.0825727
NALF1 NALCN channel auxiliary factor 1 -0.0782265
SNTG1 syntrophin, gamma 1 -0.069654
MT2A metallothionein 2A -0.0657782
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0620411
ACTG1 actin gamma 1 -0.0606654
SYT1 synaptotagmin I -0.0508165
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0475253
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0469429
LOC112694756 uncharaterized LOC112694756 -0.0457833
FGF14 fibroblast growth factor 14 -0.0455818
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0452771
CALCA calcitonin-related polypeptide alpha -0.0446996
EGR1 early growth response 1 -0.0433563
GPC5 glypican 5 -0.0431464
PTCHD4 patched domain containing 4 -0.0425754
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.042383
NBEA neurobeachin -0.0415738
NRG1 neuregulin 1 -0.041434
RPS21 ribosomal protein S21 -0.0409043
NKAIN2 Na+/K+ transporting ATPase interacting 2 -0.0404196
RPL8 ribosomal protein L8 -0.0385814
UBB ubiquitin B -0.0382956
RIT2 Ras-like without CAAX 2 -0.0380485
TOX thymocyte selection-associated high mobility group box -0.0375521
PEX5L peroxisomal biogenesis factor 5-like -0.0372998
RPL38 ribosomal protein L38 -0.0372015
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0365863
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0348515
PTMA prothymosin, alpha -0.0345708
RPS16 ribosomal protein S16 -0.0343196
PDE4D phosphodiesterase 4D, cAMP-specific -0.0338865
IFI6 interferon, alpha-inducible protein 6 -0.033474
WWOX WW domain containing oxidoreductase -0.0332823
ZNF804A zinc finger protein 804A -0.033277
ARB2A ARB2 cotranscriptional regulator A -0.033238
ADGRL2 adhesion G protein-coupled receptor L2 -0.0328727
TXNRD1 thioredoxin reductase 1 -0.0325454
SIK2 salt-inducible kinase 2 -0.0325335
FUS FUS RNA binding protein -0.0323111
NOVA1 neuro-oncological ventral antigen 1 -0.0316273
SMYD3 SET and MYND domain containing 3 -0.0313169
RPLP1 ribosomal protein, large, P1 -0.0303872
ISG15 ISG15 ubiquitin-like modifier -0.0303273
H1-0 H1.0 linker histone -0.0300608
SNAP25 synaptosomal-associated protein, 25kDa -0.0300102
TMSB10 thymosin beta 10 -0.0297615
RNF213 ring finger protein 213 -0.0297137
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0294468
HMGB1 high mobility group box 1 -0.0292842
VGF VGF nerve growth factor inducible -0.0292707
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0292029
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 -0.0291547
RPL11 ribosomal protein L11 -0.0291508
TPT1 tumor protein, translationally-controlled 1 -0.0289191
RPL35 ribosomal protein L35 -0.0288905
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2 -0.0284922
PCSK1 proprotein convertase subtilisin/kexin type 1 -0.028261
NCKAP5 NCK-associated protein 5 -0.0278263
RABGAP1L RAB GTPase activating protein 1-like -0.0276878
RALYL RALY RNA binding protein-like -0.0276189
PHF14 PHD finger protein 14 -0.0275933
FAAH2 fatty acid amide hydrolase 2 -0.0274582
RPL32 ribosomal protein L32 -0.027381
RPL12 ribosomal protein L12 -0.026631
TUBB tubulin, beta class I -0.0266305
SCFD2 sec1 family domain containing 2 -0.0263172
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0263087
S100A9 S100 calcium binding protein A9 -0.0260658
ZBTB20 zinc finger and BTB domain containing 20 -0.0260086
RPS23 ribosomal protein S23 -0.0257156
TUBB4B tubulin, beta 4B class IVb -0.025613
KIAA0825 KIAA0825 -0.0255268
DOCK5 dedicator of cytokinesis 5 -0.0254527
STXBP5L syntaxin binding protein 5-like -0.0253364
RPS5 ribosomal protein S5 -0.0253346
KCTD8 potassium channel tetramerization domain containing 8 -0.0252514
CNTNAP2 contactin associated protein-like 2 -0.0251427
TSHZ2 teashirt zinc finger homeobox 2 -0.0246673
FBXL17 F-box and leucine-rich repeat protein 17 -0.0246179
EXOC4 exocyst complex component 4 -0.0245296
SASH1 SAM and SH3 domain containing 1 -0.0244561
GPC6 glypican 6 -0.0238936
ATP5F1E ATP synthase F1 subunit epsilon -0.0237151
RPL34 ribosomal protein L34 -0.0234426
RPL23 ribosomal protein L23 -0.0233908
CDH12 cadherin 12, type 2 (N-cadherin 2) -0.0232861
POU6F2 POU class 6 homeobox 2 -0.0232039
RPLP0 ribosomal protein, large, P0 -0.0228184
CNTNAP5 contactin associated protein-like 5 -0.0227485
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0226981
CNKSR3 CNKSR family member 3 -0.0223739
RPL35A ribosomal protein L35a -0.022342
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0222236
DOK6 docking protein 6 -0.022183
PCDH9 protocadherin 9 -0.0221528