Pravastatin (sodium)_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pravastatin (sodium) perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pravastatin (sodium)_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AREG amphiregulin 0.17534
EREG epiregulin 0.107158
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0856693
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0848405
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0782168
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0678453
TOP1 topoisomerase (DNA) I 0.0673086
WDR43 WD repeat domain 43 0.0647034
CD36 CD36 molecule (thrombospondin receptor) 0.0626625
GOLGA4 golgin A4 0.0595667
RPS6 ribosomal protein S6 0.0568225
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.055093
RPS12 ribosomal protein S12 0.0532629
CBX3 chromobox homolog 3 0.0528612
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0513475
PRRC2C proline-rich coiled-coil 2C 0.0500365
NFXL1 nuclear transcription factor, X-box binding-like 1 0.0478799
SRRM2 serine/arginine repetitive matrix 2 0.0466979
RPS2 ribosomal protein S2 0.0466753
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0464198
RNF145 ring finger protein 145 0.0462218
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.045653
RNF43 ring finger protein 43 0.0435435
RPS8 ribosomal protein S8 0.0434239
BIRC6 baculoviral IAP repeat containing 6 0.0431689
RPS3 ribosomal protein S3 0.0429902
GPBP1 GC-rich promoter binding protein 1 0.0427561
KMT2C lysine (K)-specific methyltransferase 2C 0.0423663
FAR1 fatty acyl CoA reductase 1 0.0416625
ESYT2 extended synaptotagmin-like protein 2 0.0402275
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0397293
ZFP36L1 ZFP36 ring finger protein-like 1 0.0393045
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0385523
RBM25 RNA binding motif protein 25 0.0383144
ITPRID2 ITPR interacting domain containing 2 0.0365658
GARS1 glycyl-tRNA synthetase 1 0.036096
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0360296
PNN pinin, desmosome associated protein 0.0355784
CAMTA1 calmodulin binding transcription activator 1 0.0354527
ELP2 elongator acetyltransferase complex subunit 2 0.0351506
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0350563
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0350401
TXNRD1 thioredoxin reductase 1 0.0346883
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0345182
CEP152 centrosomal protein 152kDa 0.0341997
MACF1 microtubule-actin crosslinking factor 1 0.0340852
FLOT1 flotillin 1 0.0339723
SLMAP sarcolemma associated protein 0.0338796
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0330437
KIF5B kinesin family member 5B 0.0328522
LMO7 LIM domain 7 0.0322843
HILPDA hypoxia inducible lipid droplet-associated 0.0322461
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0322337
ZCCHC7 zinc finger, CCHC domain containing 7 0.0321744
SEC23A Sec23 homolog A (S. cerevisiae) 0.0321218
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0319967
ITGA6 integrin, alpha 6 0.0318892
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0317582
PCBP2 poly(rC) binding protein 2 0.0317195
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 0.0317051
CD44 CD44 molecule (Indian blood group) 0.0314059
THOC2 THO complex 2 0.0312106
KMT2E lysine (K)-specific methyltransferase 2E 0.0309552
SFXN1 sideroflexin 1 0.0307905
FNDC3A fibronectin type III domain containing 3A 0.0306155
SRSF11 serine/arginine-rich splicing factor 11 0.0305004
FAM120A family with sequence similarity 120A 0.0304265
DSCAM Down syndrome cell adhesion molecule 0.0300652
RPL37A ribosomal protein L37a 0.0298996
BAIAP2L1 BAI1-associated protein 2-like 1 0.0298718
SLTM SAFB-like, transcription modulator 0.0295661
FMNL2 formin-like 2 0.0290358
DSPP dentin sialophosphoprotein 0.0290322
ZNF148 zinc finger protein 148 0.028929
CHD1 chromodomain helicase DNA binding protein 1 0.028863
DDIT4 DNA-damage-inducible transcript 4 0.0279131
CPOX coproporphyrinogen oxidase 0.0277689
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0277193
BRWD1 bromodomain and WD repeat domain containing 1 0.0276759
PDLIM5 PDZ and LIM domain 5 0.0276413
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0275348
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 0.027316
COG5 component of oligomeric golgi complex 5 0.0271914
PTK2 protein tyrosine kinase 2 0.0270683
SFPQ splicing factor proline/glutamine-rich 0.027044
RPS18 ribosomal protein S18 0.0269697
CD46 CD46 molecule, complement regulatory protein 0.0269302
MT2A metallothionein 2A 0.026922
ZFP36 ZFP36 ring finger protein 0.0267313
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0265209
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0264118
MSI2 musashi RNA-binding protein 2 0.0259036
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.0258647
RPS17 ribosomal protein S17 0.0258624
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0258144
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.02578
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0257109
SCFD1 sec1 family domain containing 1 0.025621
PERP PERP, TP53 apoptosis effector 0.0254972
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0251989

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.250308
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.226188
ACTG1 actin gamma 1 -0.194842
EGR1 early growth response 1 -0.136107
TMSB10 thymosin beta 10 -0.130788
TPT1 tumor protein, translationally-controlled 1 -0.12551
IER3 immediate early response 3 -0.098156
AHNAK AHNAK nucleoprotein -0.0857756
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0767811
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0689083
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0664845
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0614148
RPL34 ribosomal protein L34 -0.0574501
HMGA2 high mobility group AT-hook 2 -0.0566191
VCL vinculin -0.0564265
RPS24 ribosomal protein S24 -0.0507663
LOC112694756 uncharaterized LOC112694756 -0.0496971
CANX calnexin -0.0492745
RPS23 ribosomal protein S23 -0.0470452
UBC ubiquitin C -0.0458886
CTSB cathepsin B -0.0447504
RPLP0 ribosomal protein, large, P0 -0.0442494
EEF2 eukaryotic translation elongation factor 2 -0.0441858
RPL32 ribosomal protein L32 -0.043903
HSPA8 heat shock 70kDa protein 8 -0.0434902
EMP1 epithelial membrane protein 1 -0.0428863
RPS4X ribosomal protein S4, X-linked -0.0401866
LAMB3 laminin, beta 3 -0.0401685
ATXN1 ataxin 1 -0.0401133
RPS15 ribosomal protein S15 -0.0401074
HMGB1 high mobility group box 1 -0.0391201
EGFR epidermal growth factor receptor -0.0377266
RAD51B RAD51 paralog B -0.0374494
RPL8 ribosomal protein L8 -0.0363941
DSG2 desmoglein 2 -0.0357587
RPS5 ribosomal protein S5 -0.0352062
FHIT fragile histidine triad -0.0347256
KDM3A lysine (K)-specific demethylase 3A -0.0345061
ITPKC inositol-trisphosphate 3-kinase C -0.0341056
RPL4 ribosomal protein L4 -0.0339497
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0339164
GNAS GNAS complex locus -0.0334042
RPL31 ribosomal protein L31 -0.0328013
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0326692
IARS1 isoleucyl-tRNA synthetase 1 -0.0326162
CALU calumenin -0.0325023
TUBB tubulin, beta class I -0.032216
KLF6 Kruppel-like factor 6 -0.0318315
LAMA4 laminin, alpha 4 -0.0313998
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0305907
LOC102724023 ES1 protein homolog, mitochondrial -0.0302742
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0300564
CALR calreticulin -0.0296975
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0296656
RPS16 ribosomal protein S16 -0.0296497
ARF1 ADP-ribosylation factor 1 -0.0292468
SMYD3 SET and MYND domain containing 3 -0.029237
HLA-B major histocompatibility complex, class I, B -0.0291438
VDAC1 voltage-dependent anion channel 1 -0.0285333
HDLBP high density lipoprotein binding protein -0.0284657
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 -0.0281904
ANXA2 annexin A2 -0.0280558
RPL35A ribosomal protein L35a -0.0276895
NDRG1 N-myc downstream regulated 1 -0.0273023
HMGA1 high mobility group AT-hook 1 -0.0267174
KPNB1 karyopherin (importin) beta 1 -0.0266672
MAML3 mastermind-like 3 (Drosophila) -0.026664
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0266476
FHL2 four and a half LIM domains 2 -0.0264062
EXT1 exostosin glycosyltransferase 1 -0.0258181
EEF1B2 eukaryotic translation elongation factor 1 beta 2 -0.0256921
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0256214
RPL7A ribosomal protein L7a -0.0255441
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.02536
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0250435
RPS11 ribosomal protein S11 -0.0245836
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0245495
LAMC2 laminin, gamma 2 -0.0245161
YY1 YY1 transcription factor -0.0243629
FTL ferritin, light polypeptide -0.0239095
CDK13 cyclin-dependent kinase 13 -0.0237207
CCND1 cyclin D1 -0.02359
RASAL2 RAS protein activator like 2 -0.0229005
SQSTM1 sequestosome 1 -0.0228092
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0227659
ARMH4 armadillo like helical domain containing 4 -0.02258
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0224042
TMEM123 transmembrane protein 123 -0.0223656
TFRC transferrin receptor -0.0220835
CLTC clathrin, heavy chain (Hc) -0.0219583
S100A10 S100 calcium binding protein A10 -0.0218812
RPL36 ribosomal protein L36 -0.0218319
RPLP1 ribosomal protein, large, P1 -0.0217813
KRT8 keratin 8, type II -0.0217557
EHBP1 EH domain binding protein 1 -0.0217337
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0215289
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0214725
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0214536
RPLP2 ribosomal protein, large, P2 -0.0214314
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0213506