Pravastatin Gene Set

Dataset DrugBank Drug Targets
Category physical interactions
Type drug
Description A carboxylic ester resulting from the formal condensation of (S)-2-methylbutyric acid with the hydroxy group adjacent to the ring junction of (3R,5R)-7-[(1S,2S,6S,8S,8aR)-6,8-dihydroxy-2-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid. Derived from microbial transformation of mevastatin, pravastatin is a reversible inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA). The sodium salt is used for lowering cholesterol and preventing cardiovascular disease. It is one of the lower potency statins, but has the advantage of fewer side effects compared with lovastatin and simvastatin. (Chemical Entities of Biological Interest Ontology, CHEBI_63618)
External Link http://www.drugbank.ca/drugs/DB00175
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Genes

19 interacting proteins for the Pravastatin drug from the curated DrugBank Drug Targets dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11
SLC22A6 solute carrier family 22 (organic anion transporter), member 6
SLC22A7 solute carrier family 22 (organic anion transporter), member 7
SLC22A8 solute carrier family 22 (organic anion transporter), member 8
SLCO1A2 solute carrier organic anion transporter family, member 1A2
SLCO1B1 solute carrier organic anion transporter family, member 1B1
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SLCO2B1 solute carrier organic anion transporter family, member 2B1