Premature Aging Syndrome Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
External Link https://www.disgenet.org/browser/0/1/0/C0231341
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Genes

131 genes associated with the disease Premature Aging Syndrome in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
A1CF APOBEC1 complementation factor
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
AGTR2 angiotensin II receptor, type 2
ANGPTL2 angiopoietin-like 2
APOE apolipoprotein E
APP amyloid beta (A4) precursor protein
APTX aprataxin
AR androgen receptor
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ASIP agouti signaling protein
ASPA aspartoacylase
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATG5 autophagy related 5
ATM ATM serine/threonine kinase
BANF1 barrier to autointegration factor 1
BCL2 B-cell CLL/lymphoma 2
BLM Bloom syndrome, RecQ helicase-like
BMI1 BMI1 proto-oncogene, polycomb ring finger
BRCA1 breast cancer 1, early onset
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
C3 complement component 3
CASP2 caspase 2, apoptosis-related cysteine peptidase
CAT catalase
CAV1 caveolin 1, caveolae protein, 22kDa
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CFDP1 craniofacial development protein 1
CHMP1B charged multivesicular body protein 1B
CISD2 CDGSH iron sulfur domain 2
CLOCK clock circadian regulator
COMMD3-BMI1 COMMD3-BMI1 readthrough
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen)
CSH2 chorionic somatomammotropin hormone 2
CUL4A cullin 4A
CYLD cylindromatosis (turban tumor syndrome)
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
DKC1 dyskeratosis congenita 1, dyskerin
DPP4 dipeptidyl-peptidase 4
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2
ELK1 ELK1, member of ETS oncogene family
ELN elastin
EMD emerin
ENOSF1 enolase superfamily member 1
EPHB2 EPH receptor B2
ERCC2 excision repair cross-complementation group 2
ERCC3 excision repair cross-complementation group 3
ERCC4 excision repair cross-complementation group 4
ERCC6 excision repair cross-complementation group 6
ERCC8 excision repair cross-complementation group 8
EXOSC2 exosome component 2
EXT1 exostosin glycosyltransferase 1
FGF1 fibroblast growth factor 1 (acidic)
FGF23 fibroblast growth factor 23
FOXO3 forkhead box O3
FOXP3 forkhead box P3
FUS FUS RNA binding protein
G6PD glucose-6-phosphate dehydrogenase
GEMIN4 gem (nuclear organelle) associated protein 4
GLO1 glyoxalase I
GUSB glucuronidase, beta
HIST1H1E histone cluster 1, H1e
HSPA9 heat shock 70kDa protein 9 (mortalin)
HTRA2 HtrA serine peptidase 2
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP3 insulin-like growth factor binding protein 3
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
KCNH4 potassium channel, voltage gated eag related subfamily H, member 4
KCNH8 potassium channel, voltage gated eag related subfamily H, member 8
KL klotho
LBR lamin B receptor
LMNA lamin A/C
LPA lipoprotein, Lp(a)
MAPK1 mitogen-activated protein kinase 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MECP2 methyl CpG binding protein 2
MMP9 matrix metallopeptidase 9
MUC1 mucin 1, cell surface associated
MYOD1 myogenic differentiation 1
NCOR2 nuclear receptor corepressor 2
NFE2L2 nuclear factor, erythroid 2-like 2
NHP2 NHP2 ribonucleoprotein
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
POLG polymerase (DNA directed), gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PYCR1 pyrroline-5-carboxylate reductase 1
RAD51 RAD51 recombinase
RBBP4 retinoblastoma binding protein 4
RECQL4 RecQ protein-like 4
RECQL5 RecQ protein-like 5
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
ROPN1L rhophilin associated tail protein 1-like
RUNX2 runt-related transcription factor 2
SCT secretin
SENP6 SUMO1/sentrin specific peptidase 6
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP1 secreted frizzled-related protein 1
SIRT1 sirtuin 1
SIRT2 sirtuin 2
SIRT6 sirtuin 6
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SNAI2 snail family zinc finger 2
SOD1 superoxide dismutase 1, soluble
SOD2 superoxide dismutase 2, mitochondrial
SOD3 superoxide dismutase 3, extracellular
SOX2 SRY (sex determining region Y)-box 2
SPNS1 spinster homolog 1 (Drosophila)
SPRTN SprT-like N-terminal domain
SRF serum response factor (c-fos serum response element-binding transcription factor)
SRSF5 serine/arginine-rich splicing factor 5
TBPL1 TBP-like 1
TERF2 telomeric repeat binding factor 2
TFAM transcription factor A, mitochondrial
TH tyrosine hydroxylase
TMEM201 transmembrane protein 201
TNMD tenomodulin
TOP3A topoisomerase (DNA) III alpha
TP53 tumor protein p53
TP63 tumor protein p63
TUSC2 tumor suppressor candidate 2
TWNK twinkle mtDNA helicase
VCP valosin containing protein
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
WRN Werner syndrome, RecQ helicase-like
WRNIP1 Werner helicase interacting protein 1
XPO1 exportin 1
ZMPSTE24 zinc metallopeptidase STE24