Premature Menopause Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
External Link https://www.disgenet.org/browser/0/1/0/C0025322
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Genes

270 genes associated with the disease Premature Menopause in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
AARS2 alanyl-tRNA synthetase 2, mitochondrial
ACAT2 acetyl-CoA acetyltransferase 2
ACSL6 acyl-CoA synthetase long-chain family member 6
ACTB actin, beta
ACVR2B activin A receptor, type IIB
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16
ADAMTS19 ADAM metallopeptidase with thrombospondin type 1 motif, 19
ADIPOQ adiponectin, C1Q and collagen domain containing
AFF2 AF4/FMR2 family, member 2
AGFG2 ArfGAP with FG repeats 2
AGTR2 angiotensin II receptor, type 2
AHR aryl hydrocarbon receptor
AIRE autoimmune regulator
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALB albumin
AMH anti-Mullerian hormone
AMHR2 anti-Mullerian hormone receptor, type II
AR androgen receptor
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
BAX BCL2-associated X protein
BBS9 Bardet-Biedl syndrome 9
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide
BDNF brain-derived neurotrophic factor
BMP15 bone morphogenetic protein 15
BMP2 bone morphogenetic protein 2
BMP4 bone morphogenetic protein 4
BMPR1B bone morphogenetic protein receptor, type IB
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
BNC1 basonuclin 1
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
BRD2 bromodomain containing 2
BRSK1 BR serine/threonine kinase 1
C6ORF47 chromosome 6 open reading frame 47
CALCA calcitonin-related polypeptide alpha
CASP10 caspase 10, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CBX2 chromobox homolog 2
CD19 CD19 molecule
CD38 CD38 molecule
CD63 CD63 molecule
CDH23 cadherin-related 23
CDK1 cyclin-dependent kinase 1
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEP164 centrosomal protein 164kDa
CEP290 centrosomal protein 290kDa
CER1 cerberus 1, DAN family BMP antagonist
CHDH choline dehydrogenase
CIDEB cell death-inducing DFFA-like effector b
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CNTNAP2 contactin associated protein-like 2
COMT catechol-O-methyltransferase
CPEB1 cytoplasmic polyadenylation element binding protein 1
CRP C-reactive protein, pentraxin-related
CSF1R colony stimulating factor 1 receptor
CXCL12 chemokine (C-X-C motif) ligand 12
CXCR4 chemokine (C-X-C motif) receptor 4
CYB5A cytochrome b5 type A (microsomal)
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1
CYP8B1 cytochrome P450, family 8, subfamily B, polypeptide 1
DACH2 dachshund family transcription factor 2
DAZL deleted in azoospermia-like
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase)
DCAF17 DDB1 and CUL4 associated factor 17
DCTN6 dynactin 6
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DGAT2 diacylglycerol O-acyltransferase 2
DIAPH2 diaphanous-related formin 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLX5 distal-less homeobox 5
DLX6 distal-less homeobox 6
DMC1 DNA meiotic recombinase 1
EIF2B1 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa
EIF2B4 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa
EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1
ERAL1 Era-like 12S mitochondrial rRNA chaperone 1
ERCC6 excision repair cross-complementation group 6
ERN1 endoplasmic reticulum to nucleus signaling 1
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
EXO1 exonuclease 1
F9 coagulation factor IX
FAM175A family with sequence similarity 175, member A
FANCA Fanconi anemia, complementation group A
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FIGLA folliculogenesis specific basic helix-loop-helix
FMR1 fragile X mental retardation 1
FOXE1 forkhead box E1
FOXL2 forkhead box L2
FOXO1 forkhead box O1
FOXO3 forkhead box O3
FOXO4 forkhead box O4
FSHB follicle stimulating hormone, beta polypeptide
FSHR follicle stimulating hormone receptor
FST follistatin
GADD45B growth arrest and DNA-damage-inducible, beta
GAL galanin/GMAP prepropeptide
GALT galactose-1-phosphate uridylyltransferase
GC group-specific component (vitamin D binding protein)
GCG glucagon
GDF9 growth differentiation factor 9
GPR3 G protein-coupled receptor 3
HACD1 3-hydroxyacyl-CoA dehydratase 1
HARS2 histidyl-tRNA synthetase 2, mitochondrial
HDX highly divergent homeobox
HELQ helicase, POLQ-like
HFM1 HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HNF1B HNF1 homeobox B
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4
IFI27 interferon, alpha-inducible protein 27
IFT54 intraflagellar transport 54
IGF2R insulin-like growth factor 2 receptor
IL2 interleukin 2
IL21 interleukin 21
IL4 interleukin 4
IL6 interleukin 6
INHA inhibin, alpha
INSL3 insulin-like 3 (Leydig cell)
INVS inversin
IQCB1 IQ motif containing B1
JAK2 Janus kinase 2
KDR kinase insert domain receptor
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KITLG KIT ligand
KL klotho
KLK3 kallikrein-related peptidase 3
LAMC1 laminin, gamma 1 (formerly LAMB2)
LARS2 leucyl-tRNA synthetase 2, mitochondrial
LGALS1 lectin, galactoside-binding, soluble, 1
LHB luteinizing hormone beta polypeptide
LHX8 LIM homeobox 8
LIF leukemia inhibitory factor
LIN28A lin-28 homolog A (C. elegans)
LMNA lamin A/C
MAP3K15 mitogen-activated protein kinase kinase kinase 15
MCM3AP minichromosome maintenance complex component 3 associated protein
MCM8 minichromosome maintenance complex component 8
MCM9 minichromosome maintenance complex component 9
MEGF8 multiple EGF-like-domains 8
MEIOB meiosis specific with OB domains
MMP2 matrix metallopeptidase 2
MRPS22 mitochondrial ribosomal protein S22
MSC musculin
MSH4 mutS homolog 4
MSH5 mutS homolog 5
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
NANOS3 nanos homolog 3 (Drosophila)
NBN nibrin
NOBOX NOBOX oogenesis homeobox
NOG noggin
NOTCH1 notch 1
NOTCH2 notch 2
NPAS4 neuronal PAS domain protein 4
NPHP1 nephronophthisis 1 (juvenile)
NPHP3 nephronophthisis 3 (adolescent)
NPHP4 nephronophthisis 4
NPY2R neuropeptide Y receptor Y2
NR1H3 nuclear receptor subfamily 1, group H, member 3
NR1H4 nuclear receptor subfamily 1, group H, member 4
NR5A1 nuclear receptor subfamily 5, group A, member 1
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11
NUP107 nucleoporin 107kDa
OSR2 odd-skipped related transciption factor 2
OXA1L oxidase (cytochrome c) assembly 1-like
PARP1 poly (ADP-ribose) polymerase 1
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase
PCSK1 proprotein convertase subtilisin/kexin type 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDPK1 3-phosphoinositide dependent protein kinase 1
PER1 period circadian clock 1
PER2 period circadian clock 2
PGRMC1 progesterone receptor membrane component 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PMM2 phosphomannomutase 2
POF1B premature ovarian failure, 1B
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
POLG polymerase (DNA directed), gamma
POLR3H polymerase (RNA) III (DNA directed) polypeptide H (22.9kD)
POMC proopiomelanocortin
POU5F1 POU class 5 homeobox 1
PRDX2 peroxiredoxin 2
PREPL prolyl endopeptidase-like
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRKCD protein kinase C, delta
PRL prolactin
PRLR prolactin receptor
PSMC3IP PSMC3 interacting protein
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
PTEN phosphatase and tensin homolog
PTH2R parathyroid hormone 2 receptor
PUM1 pumilio RNA-binding family member 1
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
REN renin
RGPD2 RANBP2-like and GRIP domain containing 2
RIN2 Ras and Rab interactor 2
RPL10 ribosomal protein L10
RPS26 ribosomal protein S26
RUNX2 runt-related transcription factor 2
S1PR1 sphingosine-1-phosphate receptor 1
SALL4 spalt-like transcription factor 4
SDCCAG8 serologically defined colon cancer antigen 8
SELENBP1 selenium binding protein 1
SEMA6C sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C
SENP1 SUMO1/sentrin specific peptidase 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SH2B2 SH2B adaptor protein 2
SHBG sex hormone-binding globulin
SHOX short stature homeobox
SIRT1 sirtuin 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SOHLH1 spermatogenesis and oogenesis specific basic helix-loop-helix 1
SOHLH2 spermatogenesis and oogenesis specific basic helix-loop-helix 2
SPATA22 spermatogenesis associated 22
SPIDR scaffolding protein involved in DNA repair
SPO11 SPO11 meiotic protein covalently bound to DSB
SSSCA1 Sjogren syndrome/scleroderma autoantigen 1
STAG3 stromal antigen 3
STRA8 stimulated by retinoic acid 8
SYCE1 synaptonemal complex central element protein 1
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TAGLN transgelin
TBPL2 TATA box binding protein like 2
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TERT telomerase reverse transcriptase
TG thyroglobulin
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGFBR3 transforming growth factor, beta receptor III
TICAM2 toll-like receptor adaptor molecule 2
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast)
TLK1 tousled-like kinase 1
TMED7 transmembrane emp24 protein transport domain containing 7
TMED7-TICAM2 TMED7-TICAM2 readthrough
TMEM150B transmembrane protein 150B
TMEM206 transmembrane protein 206
TNF tumor necrosis factor
TP63 tumor protein p63
TPO thyroid peroxidase
TRIM37 tripartite motif containing 37
TSC1 tuberous sclerosis 1
TSHB thyroid stimulating hormone, beta
TYMS thymidylate synthetase
USP8 ubiquitin specific peptidase 8
USP9X ubiquitin specific peptidase 9, X-linked
VEGFA vascular endothelial growth factor A
VTA1 vesicle (multivesicular body) trafficking 1
WDR19 WD repeat domain 19
WDR62 WD repeat domain 62
WNT4 wingless-type MMTV integration site family, member 4
WT1 Wilms tumor 1
XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
XPO5 exportin 5
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZP3 zona pellucida glycoprotein 3 (sperm receptor)