Prestwick-1082-3530 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the Prestwick-1082-3530 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM22 ADAM metallopeptidase domain 22
ADD2 adducin 2 (beta)
ANKRD7 ankyrin repeat domain 7
ANP32A-IT1 ANP32A intronic transcript 1
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APOM apolipoprotein M
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARPIN actin-related protein 2/3 complex inhibitor
ARTN artemin
BHLHE41 basic helix-loop-helix family, member e41
BTN2A2 butyrophilin, subfamily 2, member A2
C3 complement component 3
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CASP1 caspase 1, apoptosis-related cysteine peptidase
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CREBZF CREB/ATF bZIP transcription factor
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
EMP1 epithelial membrane protein 1
EXT1 exostosin glycosyltransferase 1
FBXO11 F-box protein 11
FGD1 FYVE, RhoGEF and PH domain containing 1
FHL1 four and a half LIM domains 1
GLP1R glucagon-like peptide 1 receptor
GLRA3 glycine receptor, alpha 3
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
GPLD1 glycosylphosphatidylinositol specific phospholipase D1
GSK3A glycogen synthase kinase 3 alpha
GUSBP3 glucuronidase, beta pseudogene 3
HCFC1 host cell factor C1
HIST1H4A histone cluster 1, H4a
HIST1H4E histone cluster 1, H4e
HLA-DOA major histocompatibility complex, class II, DO alpha
HMOX1 heme oxygenase 1
ICOSLG inducible T-cell co-stimulator ligand
IL5RA interleukin 5 receptor, alpha
ING4 inhibitor of growth family, member 4
INHBE inhibin, beta E
ITGA6 integrin, alpha 6
ITIH5 inter-alpha-trypsin inhibitor heavy chain family, member 5
KIF24 kinesin family member 24
KLHL23 kelch-like family member 23
KRAS Kirsten rat sarcoma viral oncogene homolog
LOC729164 hCG1732469
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1C1 mannosidase, alpha, class 1C, member 1
MARS methionyl-tRNA synthetase
MEF2C myocyte enhancer factor 2C
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MRAS muscle RAS oncogene homolog
MUC3B mucin 3B, cell surface associated
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
NF2 neurofibromin 2 (merlin)
NFX1 nuclear transcription factor, X-box binding 1
NOX5 NADPH oxidase, EF-hand calcium binding domain 5
NT5E 5'-nucleotidase, ecto (CD73)
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OR2H2 olfactory receptor, family 2, subfamily H, member 2
PARP11 poly (ADP-ribose) polymerase family, member 11
PAX2 paired box 2
PDE3B phosphodiesterase 3B, cGMP-inhibited
PIGO phosphatidylinositol glycan anchor biosynthesis, class O
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PPARD peroxisome proliferator-activated receptor delta
PSCA prostate stem cell antigen
PTRF polymerase I and transcript release factor
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAB6B RAB6B, member RAS oncogene family
RGS2 regulator of G-protein signaling 2
RIMS2 regulating synaptic membrane exocytosis 2
RNF19B ring finger protein 19B
RNFT1 ring finger protein, transmembrane 1
RPL35A ribosomal protein L35a
SCN1B sodium channel, voltage gated, type I beta subunit
SDC3 syndecan 3
SLC1A7 solute carrier family 1 (glutamate transporter), member 7
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD1 SMAD family member 1
SOWAHC sosondowah ankyrin repeat domain family member C
SPDEF SAM pointed domain containing ETS transcription factor
SYBU syntabulin (syntaxin-interacting)
TMCC2 transmembrane and coiled-coil domain family 2
TMEM209 transmembrane protein 209
TMPRSS15 transmembrane protease, serine 15
TREX1 three prime repair exonuclease 1
TRIM14 tripartite motif containing 14
UNC5B unc-5 homolog B (C. elegans)
VNN2 vanin 2
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
YTHDC2 YTH domain containing 2
ZBTB7A zinc finger and BTB domain containing 7A
ZNF136 zinc finger protein 136
ZNF551 zinc finger protein 551
ZNF609 zinc finger protein 609
ZNF783 zinc finger family member 783

decreased expression

Symbol Name
ABI3BP ABI family, member 3 (NESH) binding protein
ACSBG2 acyl-CoA synthetase bubblegum family member 2
ADAP2 ArfGAP with dual PH domains 2
AMT aminomethyltransferase
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
APOLD1 apolipoprotein L domain containing 1
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASPHD1 aspartate beta-hydroxylase domain containing 1
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BANK1 B-cell scaffold protein with ankyrin repeats 1
C9ORF9 chromosome 9 open reading frame 9
CACNG1 calcium channel, voltage-dependent, gamma subunit 1
CAPN15 calpain 15
CBX8 chromobox homolog 8
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CIDEB cell death-inducing DFFA-like effector b
CLCA1 chloride channel accessory 1
CLSPN claspin
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CPTP ceramide-1-phosphate transfer protein
CRY2 cryptochrome circadian clock 2
CXCR2 chemokine (C-X-C motif) receptor 2
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
DAGLA diacylglycerol lipase, alpha
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
EMID1 EMI domain containing 1
EXD3 exonuclease 3'-5' domain containing 3
FABP6 fatty acid binding protein 6, ileal
FBRS fibrosin
FGF23 fibroblast growth factor 23
FLJ11710 uncharacterized protein FLJ11710
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GNG7 guanine nucleotide binding protein (G protein), gamma 7
HIST1H2BC histone cluster 1, H2bc
HIST1H2BJ histone cluster 1, H2bj
HOXC5 homeobox C5
HPN hepsin
KCTD7 potassium channel tetramerization domain containing 7
KDM8 lysine (K)-specific demethylase 8
LAX1 lymphocyte transmembrane adaptor 1
LMNB2 lamin B2
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LRRC20 leucine rich repeat containing 20
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAGEA3 melanoma antigen family A3
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MCOLN1 mucolipin 1
MFAP2 microfibrillar-associated protein 2
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MMP2 matrix metallopeptidase 2
MT1H metallothionein 1H
NCALD neurocalcin delta
NDE1 nudE neurodevelopment protein 1
NHEJ1 nonhomologous end-joining factor 1
NKX3-2 NK3 homeobox 2
NNAT neuronatin
NPFFR1 neuropeptide FF receptor 1
NPIPB15 nuclear pore complex interacting protein family, member B15
OLFML2A olfactomedin-like 2A
PDE8B phosphodiesterase 8B
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PGPEP1 pyroglutamyl-peptidase I
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
POLL polymerase (DNA directed), lambda
POM121 POM121 transmembrane nucleoporin
PRODH proline dehydrogenase (oxidase) 1
PRR14L proline rich 14-like
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PTPN9 protein tyrosine phosphatase, non-receptor type 9
PVRL3 poliovirus receptor-related 3
RASL11B RAS-like, family 11, member B
RNF126P1 ring finger protein 126 pseudogene 1
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
RUSC2 RUN and SH3 domain containing 2
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
SLC44A1 solute carrier family 44 (choline transporter), member 1
SMA4 glucuronidase, beta pseudogene
SP1 Sp1 transcription factor
STX1A syntaxin 1A (brain)
STXBP2 syntaxin binding protein 2
SULT4A1 sulfotransferase family 4A, member 1
TCP10 t-complex 10
TCTN2 tectonic family member 2
TMEM120B transmembrane protein 120B
TMEM45A transmembrane protein 45A
TTC33 tetratricopeptide repeat domain 33
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
USP20 ubiquitin specific peptidase 20
VLDLR very low density lipoprotein receptor
WDR4 WD repeat domain 4
XK X-linked Kx blood group
ZBTB25 zinc finger and BTB domain containing 25
ZBTB6 zinc finger and BTB domain containing 6
ZNF282 zinc finger protein 282
ZNF34 zinc finger protein 34
ZNF654 zinc finger protein 654