Prestwick-1083-3538 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the Prestwick-1083-3538 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ACAP1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
ACTL8 actin-like 8
ADAM28 ADAM metallopeptidase domain 28
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
AHNAK AHNAK nucleoprotein
AKAP8L A kinase (PRKA) anchor protein 8-like
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
AMELY amelogenin, Y-linked
AMPD3 adenosine monophosphate deaminase 3
ANGPTL2 angiopoietin-like 2
ANKLE2 ankyrin repeat and LEM domain containing 2
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APOL3 apolipoprotein L, 3
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
ARHGAP33 Rho GTPase activating protein 33
ART1 ADP-ribosyltransferase 1
ATAT1 alpha tubulin acetyltransferase 1
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
ATP7A ATPase, Cu++ transporting, alpha polypeptide
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C21ORF2 chromosome 21 open reading frame 2
CD83 CD83 molecule
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CLEC2D C-type lectin domain family 2, member D
CNPY4 canopy FGF signaling regulator 4
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTBP2 C-terminal binding protein 2
DFNB31 deafness, autosomal recessive 31
DRICH1 aspartate-rich 1
EDA ectodysplasin A
ELL elongation factor RNA polymerase II
ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4
EPHB2 EPH receptor B2
ERAP1 endoplasmic reticulum aminopeptidase 1
EXTL3 exostosin-like glycosyltransferase 3
FLJ11710 uncharacterized protein FLJ11710
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GSPT1 G1 to S phase transition 1
HIST1H4A histone cluster 1, H4a
HIST1H4F histone cluster 1, H4f
HLA-C major histocompatibility complex, class I, C
IFT54 intraflagellar transport 54
IGL immunoglobulin lambda locus
IL11 interleukin 11
IPO8 importin 8
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1
KIAA1456 KIAA1456
KLF2 Kruppel-like factor 2
KMT2A lysine (K)-specific methyltransferase 2A
LARP4B La ribonucleoprotein domain family, member 4B
LINC00260 long intergenic non-protein coding RNA 260
MALT1 MALT1 paracaspase
MAPK7 mitogen-activated protein kinase 7
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MBD3 methyl-CpG binding domain protein 3
MORN1 MORN repeat containing 1
MUC3B mucin 3B, cell surface associated
MYLK myosin light chain kinase
MYOZ2 myozenin 2
NAT6 N-acetyltransferase 6 (GCN5-related)
NCOA2 nuclear receptor coactivator 2
NEU2 sialidase 2 (cytosolic sialidase)
NMT2 N-myristoyltransferase 2
NOX5 NADPH oxidase, EF-hand calcium binding domain 5
NRSN2 neurensin 2
OGFR opioid growth factor receptor
PIGC phosphatidylinositol glycan anchor biosynthesis, class C
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLCD1 phospholipase C, delta 1
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PXN paxillin
RBMS2 RNA binding motif, single stranded interacting protein 2
RIN1 Ras and Rab interactor 1
RPS3A ribosomal protein S3A
RPS4Y1 ribosomal protein S4, Y-linked 1
RYR1 ryanodine receptor 1 (skeletal)
SAG S-antigen; retina and pineal gland (arrestin)
SBNO1 strawberry notch homolog 1 (Drosophila)
SCN1B sodium channel, voltage gated, type I beta subunit
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SEMA4F sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F
SFTPC surfactant protein C
SHANK1 SH3 and multiple ankyrin repeat domains 1
SLC16A4 solute carrier family 16, member 4
SLC39A9 solute carrier family 39, member 9
SLIT2 slit homolog 2 (Drosophila)
TBC1D2B TBC1 domain family, member 2B
TBXA2R thromboxane A2 receptor
TEX13A testis expressed 13A
TM4SF5 transmembrane 4 L six family member 5
TMEM19 transmembrane protein 19
TRIM14 tripartite motif containing 14
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast)
VWA5A von Willebrand factor A domain containing 5A
XYLB xylulokinase homolog (H. influenzae)
YY1 YY1 transcription factor
ZFP64 ZFP64 zinc finger protein
ZNF518A zinc finger protein 518A

decreased expression

Symbol Name
ADGRE5 adhesion G protein-coupled receptor E5
ADGRG2 adhesion G protein-coupled receptor G2
ALPK1 alpha-kinase 1
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
ANKZF1 ankyrin repeat and zinc finger domain containing 1
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARRB1 arrestin, beta 1
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
BMP4 bone morphogenetic protein 4
C10ORF95 chromosome 10 open reading frame 95
C11ORF80 chromosome 11 open reading frame 80
C16ORF62 chromosome 16 open reading frame 62
CA11 carbonic anhydrase XI
CAPG capping protein (actin filament), gelsolin-like
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CERK ceramide kinase
CLCA1 chloride channel accessory 1
CTNNBIP1 catenin, beta interacting protein 1
CXCR2 chemokine (C-X-C motif) receptor 2
DAGLA diacylglycerol lipase, alpha
DPY19L1P1 DPY19L1 pseudogene 1
EFNA3 ephrin-A3
EHMT1 euchromatic histone-lysine N-methyltransferase 1
EN2 engrailed homeobox 2
ENO2 enolase 2 (gamma, neuronal)
ERMAP erythroblast membrane-associated protein (Scianna blood group)
FAM46C family with sequence similarity 46, member C
FAM63A family with sequence similarity 63, member A
FBXL15 F-box and leucine-rich repeat protein 15
FBXL2 F-box and leucine-rich repeat protein 2
FBXL6 F-box and leucine-rich repeat protein 6
FER fer (fps/fes related) tyrosine kinase
FILIP1L filamin A interacting protein 1-like
FLT4 fms-related tyrosine kinase 4
FRMD1 FERM domain containing 1
FURIN furin (paired basic amino acid cleaving enzyme)
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GRTP1 growth hormone regulated TBC protein 1
GSTCD glutathione S-transferase, C-terminal domain containing
HIST1H2AK histone cluster 1, H2ak
HOXC10 homeobox C10
IDI2-AS1 IDI2 antisense RNA 1
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KLHL25 kelch-like family member 25
KRT24 keratin 24, type I
LARP6 La ribonucleoprotein domain family, member 6
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LRFN3 leucine rich repeat and fibronectin type III domain containing 3
MAGEA6 melanoma antigen family A6
MCOLN1 mucolipin 1
MMP2 matrix metallopeptidase 2
MVD mevalonate (diphospho) decarboxylase
MXD3 MAX dimerization protein 3
MYL5 myosin, light chain 5, regulatory
MYO19 myosin XIX
NPTX1 neuronal pentraxin I
NT5DC3 5'-nucleotidase domain containing 3
PCSK7 proprotein convertase subtilisin/kexin type 7
PDE8B phosphodiesterase 8B
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLA2G3 phospholipase A2, group III
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PRSS22 protease, serine, 22
RAD54L2 RAD54-like 2 (S. cerevisiae)
RASL11B RAS-like, family 11, member B
REM1 RAS (RAD and GEM)-like GTP-binding 1
RNF126P1 ring finger protein 126 pseudogene 1
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
SCARA3 scavenger receptor class A, member 3
SCD5 stearoyl-CoA desaturase 5
SCRN3 secernin 3
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
SETD8 SET domain containing (lysine methyltransferase) 8
SIGLEC15 sialic acid binding Ig-like lectin 15
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SPHK1 sphingosine kinase 1
STAG3L1 stromal antigen 3-like 1 (pseudogene)
STX1A syntaxin 1A (brain)
SYNGR3 synaptogyrin 3
TBC1D19 TBC1 domain family, member 19
THRAP3 thyroid hormone receptor associated protein 3
TMLHE trimethyllysine hydroxylase, epsilon
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TOM1 target of myb1 (chicken)
TTC30A tetratricopeptide repeat domain 30A
UPK3B uroplakin 3B
USB1 U6 snRNA biogenesis 1
VASH1 vasohibin 1
WLS wntless Wnt ligand secretion mediator
ZBTB48 zinc finger and BTB domain containing 48
ZC3H3 zinc finger CCCH-type containing 3
ZNF282 zinc finger protein 282