Prestwick-1085-3554 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the Prestwick-1085-3554 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AFAP1 actin filament associated protein 1
AJAP1 adherens junctions associated protein 1
AMACR alpha-methylacyl-CoA racemase
APC adenomatous polyposis coli
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATP10B ATPase, class V, type 10B
BIN1 bridging integrator 1
C9ORF9 chromosome 9 open reading frame 9
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCDC57 coiled-coil domain containing 57
CD6 CD6 molecule
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CFHR4 complement factor H-related 4
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CIZ1 CDKN1A interacting zinc finger protein 1
CNTN5 contactin 5
COL4A1 collagen, type IV, alpha 1
CYLC2 cylicin, basic protein of sperm head cytoskeleton 2
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
DRD1 dopamine receptor D1
DYSF dysferlin
EFNA3 ephrin-A3
ERCC2 excision repair cross-complementation group 2
EXTL1 exostosin-like glycosyltransferase 1
FGFR1 fibroblast growth factor receptor 1
FLOT1 flotillin 1
FOXN2 forkhead box N2
FSTL1 follistatin-like 1
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GAP43 growth associated protein 43
GJA8 gap junction protein, alpha 8, 50kDa
GPR161 G protein-coupled receptor 161
GSTA3 glutathione S-transferase alpha 3
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic
IL1RN interleukin 1 receptor antagonist
IL22 interleukin 22
ITGB8 integrin, beta 8
KIAA1109 KIAA1109
KRT83 keratin 83, type II
LAMA2 laminin, alpha 2
LAPTM5 lysosomal protein transmembrane 5
LFNG LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
LLGL1 lethal giant larvae homolog 1 (Drosophila)
MAN1C1 mannosidase, alpha, class 1C, member 1
MAOA monoamine oxidase A
MAST2 microtubule associated serine/threonine kinase 2
MCF2L MCF.2 cell line derived transforming sequence-like
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MMP25 matrix metallopeptidase 25
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NAG18 NAG18 mRNA
NF1 neurofibromin 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
OCLM oculomedin
OPCML opioid binding protein/cell adhesion molecule-like
PARP8 poly (ADP-ribose) polymerase family, member 8
PCDH12 protocadherin 12
PKP1 plakophilin 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PODXL2 podocalyxin-like 2
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
PTCH1 patched 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1
REPS1 RALBP1 associated Eps domain containing 1
RGS12 regulator of G-protein signaling 12
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila)
RSG1 REM2 and RAB-like small GTPase 1
S100A9 S100 calcium binding protein A9
SIGLEC6 sialic acid binding Ig-like lectin 6
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5
SLC39A9 solute carrier family 39, member 9
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SNCAIP synuclein, alpha interacting protein
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
SPON1 spondin 1, extracellular matrix protein
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6
STAC SH3 and cysteine rich domain
STK11 serine/threonine kinase 11
TAC3 tachykinin 3
TAS2R10 taste receptor, type 2, member 10
TFEB transcription factor EB
TLE2 transducin-like enhancer of split 2
TMEM19 transmembrane protein 19
TMEM53 transmembrane protein 53
TSPAN12 tetraspanin 12
TUBB2B tubulin, beta 2B class IIb
UBXN1 UBX domain protein 1
VPS9D1 VPS9 domain containing 1
WAPAL wings apart-like homolog (Drosophila)
XAF1 XIAP associated factor 1
YIPF2 Yip1 domain family, member 2
ZFP36L1 ZFP36 ring finger protein-like 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF3 zinc finger protein 3
ZNF639 zinc finger protein 639

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ABCA11P ATP-binding cassette, sub-family A (ABC1), member 11, pseudogene
ABHD14A abhydrolase domain containing 14A
ACADSB acyl-CoA dehydrogenase, short/branched chain
ACSF2 acyl-CoA synthetase family member 2
AMPD2 adenosine monophosphate deaminase 2
ANXA2P3 annexin A2 pseudogene 3
AP4M1 adaptor-related protein complex 4, mu 1 subunit
ASPHD1 aspartate beta-hydroxylase domain containing 1
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BAHCC1 BAH domain and coiled-coil containing 1
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BBC3 BCL2 binding component 3
C1ORF115 chromosome 1 open reading frame 115
C22ORF29 chromosome 22 open reading frame 29
C5 complement component 5
C6ORF47 chromosome 6 open reading frame 47
CAPG capping protein (actin filament), gelsolin-like
CBX7 chromobox homolog 7
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CENPC centromere protein C
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CLSPN claspin
CNN2 calponin 2
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
DNMBP dynamin binding protein
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DUSP2 dual specificity phosphatase 2
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
EPN3 epsin 3
FAM193B family with sequence similarity 193, member B
FGF23 fibroblast growth factor 23
GMEB1 glucocorticoid modulatory element binding protein 1
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPX2 glutathione peroxidase 2
GSTCD glutathione S-transferase, C-terminal domain containing
GUSBP3 glucuronidase, beta pseudogene 3
HIRA histone cell cycle regulator
HPS6 Hermansky-Pudlak syndrome 6
IFT140 intraflagellar transport 140
IL17RA interleukin 17 receptor A
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KLF3 Kruppel-like factor 3 (basic)
LAMB3 laminin, beta 3
LIG4 ligase IV, DNA, ATP-dependent
LOC642236 FSHD region gene 1 pseudogene
LY6D lymphocyte antigen 6 complex, locus D
LYRM9 LYR motif containing 9
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
NES nestin
NT5DC3 5'-nucleotidase domain containing 3
OLFML2A olfactomedin-like 2A
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PCDHB3 protocadherin beta 3
PCDHB8 protocadherin beta 8
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1
PIGH phosphatidylinositol glycan anchor biosynthesis, class H
PIGL phosphatidylinositol glycan anchor biosynthesis, class L
PLD3 phospholipase D family, member 3
PLEKHA6 pleckstrin homology domain containing, family A member 6
PNPLA6 patatin-like phospholipase domain containing 6
POM121 POM121 transmembrane nucleoporin
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
PTDSS2 phosphatidylserine synthase 2
RAB33B RAB33B, member RAS oncogene family
RPAP1 RNA polymerase II associated protein 1
RPL10L ribosomal protein L10-like
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
SIGLEC15 sialic acid binding Ig-like lectin 15
SKA1 spindle and kinetochore associated complex subunit 1
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
SSBP3 single stranded DNA binding protein 3
SULT4A1 sulfotransferase family 4A, member 1
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TMC7 transmembrane channel-like 7
TMEM120B transmembrane protein 120B
TMPRSS3 transmembrane protease, serine 3
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TPK1 thiamin pyrophosphokinase 1
TRABD TraB domain containing
TRIM5 tripartite motif containing 5
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TTC23 tetratricopeptide repeat domain 23
TUBA3D tubulin, alpha 3d
USB1 U6 snRNA biogenesis 1
UST uronyl-2-sulfotransferase
VAX2 ventral anterior homeobox 2
VGF VGF nerve growth factor inducible
WDR47 WD repeat domain 47
XYLT2 xylosyltransferase II
ZBED8 zinc finger, BED-type containing 8
ZNF652 zinc finger protein 652