Prestwick-1100-3880 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the Prestwick-1100-3880 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A2M alpha-2-macroglobulin
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACVR1B activin A receptor, type IB
ADCY2 adenylate cyclase 2 (brain)
ALCAM activated leukocyte cell adhesion molecule
AOC3 amine oxidase, copper containing 3
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ASCL1 achaete-scute family bHLH transcription factor 1
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
BMP10 bone morphogenetic protein 10
C19ORF66 chromosome 19 open reading frame 66
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CDC25C cell division cycle 25C
CLDN11 claudin 11
CNN1 calponin 1, basic, smooth muscle
CNTN1 contactin 1
CPNE7 copine VII
CTGF connective tissue growth factor
CYLC2 cylicin, basic protein of sperm head cytoskeleton 2
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12
DNASE2B deoxyribonuclease II beta
DUSP4 dual specificity phosphatase 4
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EIF5A2 eukaryotic translation initiation factor 5A2
ELAC1 elaC ribonuclease Z 1
EMC3 ER membrane protein complex subunit 3
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
EYA3 EYA transcriptional coactivator and phosphatase 3
FAM49A family with sequence similarity 49, member A
FAM63B family with sequence similarity 63, member B
FAM66D family with sequence similarity 66, member D
FGFR1 fibroblast growth factor receptor 1
FLI1 Fli-1 proto-oncogene, ETS transcription factor
GHRHR growth hormone releasing hormone receptor
GJD2 gap junction protein, delta 2, 36kDa
GPR137 G protein-coupled receptor 137
GRIK5 glutamate receptor, ionotropic, kainate 5
GSK3A glycogen synthase kinase 3 alpha
GTPBP1 GTP binding protein 1
HIRA histone cell cycle regulator
HMOX1 heme oxygenase 1
ICOSLG inducible T-cell co-stimulator ligand
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IL2RB interleukin 2 receptor, beta
IRF4 interferon regulatory factor 4
ITPKA inositol-trisphosphate 3-kinase A
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
JAK2 Janus kinase 2
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KCNQ2 potassium channel, voltage gated KQT-like subfamily Q, member 2
KHSRP KH-type splicing regulatory protein
KIFC1 kinesin family member C1
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLRAP1 killer cell lectin-like receptor subfamily A pseudogene 1
KXD1 KxDL motif containing 1
LLGL1 lethal giant larvae homolog 1 (Drosophila)
LMNB1 lamin B1
LUZP4 leucine zipper protein 4
MAP2K5 mitogen-activated protein kinase kinase 5
MAPT microtubule-associated protein tau
MFSD7 major facilitator superfamily domain containing 7
MMP25 matrix metallopeptidase 25
NELL2 NEL-like 2 (chicken)
NF2 neurofibromin 2 (merlin)
OSBPL10 oxysterol binding protein-like 10
PCSK6 proprotein convertase subtilisin/kexin type 6
PDE4C phosphodiesterase 4C, cAMP-specific
PGAP3 post-GPI attachment to proteins 3
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
POU3F4 POU class 3 homeobox 4
PRB4 proline-rich protein BstNI subfamily 4
PSCA prostate stem cell antigen
PTAFR platelet-activating factor receptor
PXDC1 PX domain containing 1
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RBM12B RNA binding motif protein 12B
RHBDL1 rhomboid, veinlet-like 1 (Drosophila)
RND2 Rho family GTPase 2
RUFY3 RUN and FYVE domain containing 3
SETD1B SET domain containing 1B
SIM2 single-minded family bHLH transcription factor 2
SIRT5 sirtuin 5
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC4A3 solute carrier family 4 (anion exchanger), member 3
SPEG SPEG complex locus
STS steroid sulfatase (microsomal), isozyme S
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
SVIL supervillin
TBX2 T-box 2
THBS1 thrombospondin 1
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TUBA4B tubulin, alpha 4b
VN1R1 vomeronasal 1 receptor 1
ZFYVE9 zinc finger, FYVE domain containing 9
ZIM2 zinc finger, imprinted 2
ZNF3 zinc finger protein 3

decreased expression

Symbol Name
A1CF APOBEC1 complementation factor
ACAD10 acyl-CoA dehydrogenase family, member 10
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
AGMAT agmatine ureohydrolase (agmatinase)
ALOX12 arachidonate 12-lipoxygenase
ARMC4 armadillo repeat containing 4
BAHCC1 BAH domain and coiled-coil containing 1
BHLHB9 basic helix-loop-helix domain containing, class B, 9
BIRC7 baculoviral IAP repeat containing 7
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
CAMK1 calcium/calmodulin-dependent protein kinase I
CASZ1 castor zinc finger 1
CBX8 chromobox homolog 8
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CD1A CD1a molecule
CD83 CD83 molecule
CEP97 centrosomal protein 97kDa
CNGB3 cyclic nucleotide gated channel beta 3
CNR2 cannabinoid receptor 2 (macrophage)
CORO7 coronin 7
CRIP1 cysteine-rich protein 1 (intestinal)
CSTA cystatin A (stefin A)
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DGAT1 diacylglycerol O-acyltransferase 1
DHRS3 dehydrogenase/reductase (SDR family) member 3
DLL3 delta-like 3 (Drosophila)
DSCAM Down syndrome cell adhesion molecule
DUSP13 dual specificity phosphatase 13
EGFL7 EGF-like-domain, multiple 7
F3 coagulation factor III (thromboplastin, tissue factor)
FAM120C family with sequence similarity 120C
FAM155A family with sequence similarity 155, member A
FAM53B family with sequence similarity 53, member B
FBRS fibrosin
FKBP2 FK506 binding protein 2, 13kDa
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GAMT guanidinoacetate N-methyltransferase
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GJA9 gap junction protein, alpha 9, 59kDa
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPR27 G protein-coupled receptor 27
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14
HSF4 heat shock transcription factor 4
IRF2BP1 interferon regulatory factor 2 binding protein 1
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
JMJD4 jumonji domain containing 4
KLK8 kallikrein-related peptidase 8
KRT15 keratin 15, type I
LMO2 LIM domain only 2 (rhombotin-like 1)
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MAOB monoamine oxidase B
MAP2 microtubule-associated protein 2
MEFV Mediterranean fever
MMP17 matrix metallopeptidase 17 (membrane-inserted)
MTA2 metastasis associated 1 family, member 2
MUC3A mucin 3A, cell surface associated
MUC3B mucin 3B, cell surface associated
NKAIN1 Na+/K+ transporting ATPase interacting 1
NPIPB15 nuclear pore complex interacting protein family, member B15
NPPA natriuretic peptide A
NRGN neurogranin (protein kinase C substrate, RC3)
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PLEKHJ1 pleckstrin homology domain containing, family J member 1
PMM1 phosphomannomutase 1
PRPH peripherin
PTPRS protein tyrosine phosphatase, receptor type, S
PVRL3 poliovirus receptor-related 3
RAI2 retinoic acid induced 2
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RCAN3 RCAN family member 3
RPH3AL rabphilin 3A-like (without C2 domains)
S100A4 S100 calcium binding protein A4
SCARA3 scavenger receptor class A, member 3
SENP7 SUMO1/sentrin specific peptidase 7
SIGLEC15 sialic acid binding Ig-like lectin 15
SLC44A1 solute carrier family 44 (choline transporter), member 1
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9
SPRYD7 SPRY domain containing 7
SPTBN2 spectrin, beta, non-erythrocytic 2
STX1A syntaxin 1A (brain)
SYNC syncoilin, intermediate filament protein
TAOK1 TAO kinase 1
TBC1D2 TBC1 domain family, member 2
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TMEM209 transmembrane protein 209
TNS2 tensin 2
UBTD1 ubiquitin domain containing 1
VPS9D1 VPS9 domain containing 1
WNT16 wingless-type MMTV integration site family, member 16
ZIC3 Zic family member 3
ZNF205 zinc finger protein 205
ZNF41 zinc finger protein 41
ZNF804A zinc finger protein 804A
ZSCAN2 zinc finger and SCAN domain containing 2