Prestwick-559-2877 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the Prestwick-559-2877 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ALK anaplastic lymphoma receptor tyrosine kinase
APOM apolipoprotein M
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
BAIAP3 BAI1-associated protein 3
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BCL2A1 BCL2-related protein A1
C19ORF66 chromosome 19 open reading frame 66
C1ORF105 chromosome 1 open reading frame 105
CAV2 caveolin 2
CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEP41 centrosomal protein 41kDa
CFHR2 complement factor H-related 2
CHRNE cholinergic receptor, nicotinic, epsilon (muscle)
COL19A1 collagen, type XIX, alpha 1
CRISP2 cysteine-rich secretory protein 2
CYP4A22 cytochrome P450, family 4, subfamily A, polypeptide 22
DNAH17 dynein, axonemal, heavy chain 17
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2
ELAC2 elaC ribonuclease Z 2
ELP6 elongator acetyltransferase complex subunit 6
ERP44 endoplasmic reticulum protein 44
ESR2 estrogen receptor 2 (ER beta)
ETV4 ets variant 4
F5 coagulation factor V (proaccelerin, labile factor)
FAM131A family with sequence similarity 131, member A
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1
GRIP2 glutamate receptor interacting protein 2
HAB1 B1 for mucin
HEMK1 HemK methyltransferase family member 1
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HFE hemochromatosis
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HLA-DMB major histocompatibility complex, class II, DM beta
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14
HSPB3 heat shock 27kDa protein 3
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
IL20RA interleukin 20 receptor, alpha
INSIG1 insulin induced gene 1
KIAA1024 KIAA1024
KIR2DS4 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4
KLHL24 kelch-like family member 24
LHX1 LIM homeobox 1
LINC00312 long intergenic non-protein coding RNA 312
LPIN1 lipin 1
LRRC37A3 leucine rich repeat containing 37, member A3
MAPRE3 microtubule-associated protein, RP/EB family, member 3
MYF5 myogenic factor 5
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NNAT neuronatin
NR3C2 nuclear receptor subfamily 3, group C, member 2
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
OLAH oleoyl-ACP hydrolase
ONECUT2 one cut homeobox 2
OSBPL10 oxysterol binding protein-like 10
PAMR1 peptidase domain containing associated with muscle regeneration 1
PAPPA2 pappalysin 2
PDIA2 protein disulfide isomerase family A, member 2
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PLCH2 phospholipase C, eta 2
PLD2 phospholipase D2
PLLP plasmolipin
PML promyelocytic leukemia
POU4F1 POU class 4 homeobox 1
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PSG6 pregnancy specific beta-1-glycoprotein 6
R3HDM1 R3H domain containing 1
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
REM1 RAS (RAD and GEM)-like GTP-binding 1
REST RE1-silencing transcription factor
RGS14 regulator of G-protein signaling 14
RGS20 regulator of G-protein signaling 20
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6
RREB1 ras responsive element binding protein 1
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3
SLC22A14 solute carrier family 22, member 14
SLCO4C1 solute carrier organic anion transporter family, member 4C1
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SSTR5 somatostatin receptor 5
SSX1 synovial sarcoma, X breakpoint 1
STIM1 stromal interaction molecule 1
TCP10L t-complex 10-like
TGFB2 transforming growth factor, beta 2
TLDC1 TBC/LysM-associated domain containing 1
TRIM10 tripartite motif containing 10
TSC22D2 TSC22 domain family, member 2
TSHB thyroid stimulating hormone, beta
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)
WISP1 WNT1 inducible signaling pathway protein 1
ZNF286A zinc finger protein 286A
ZNF423 zinc finger protein 423
ZNF493 zinc finger protein 493

decreased expression

Symbol Name
ABLIM3 actin binding LIM protein family, member 3
ACAD10 acyl-CoA dehydrogenase family, member 10
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ACTG2 actin, gamma 2, smooth muscle, enteric
ADAM15 ADAM metallopeptidase domain 15
AFAP1 actin filament associated protein 1
AGBL5 ATP/GTP binding protein-like 5
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ANKRD40 ankyrin repeat domain 40
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
ARHGAP11A Rho GTPase activating protein 11A
ATG4A autophagy related 4A, cysteine peptidase
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
BFSP1 beaded filament structural protein 1, filensin
BTBD2 BTB (POZ) domain containing 2
BTF3P12 basic transcription factor 3 pseudogene 12
C1ORF159 chromosome 1 open reading frame 159
C1QTNF3 C1q and tumor necrosis factor related protein 3
CAPN5 calpain 5
CEP170B centrosomal protein 170B
CHPF chondroitin polymerizing factor
CORO1A coronin, actin binding protein, 1A
CRELD1 cysteine-rich with EGF-like domains 1
CUZD1 CUB and zona pellucida-like domains 1
DDIT3 DNA-damage-inducible transcript 3
DGKE diacylglycerol kinase, epsilon 64kDa
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DVL1 dishevelled segment polarity protein 1
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
EPB41L5 erythrocyte membrane protein band 4.1 like 5
ETAA1 Ewing tumor-associated antigen 1
FBXL2 F-box and leucine-rich repeat protein 2
FBXL6 F-box and leucine-rich repeat protein 6
FLCN folliculin
FOSL1 FOS-like antigen 1
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFT81 intraflagellar transport 81
IGFBP6 insulin-like growth factor binding protein 6
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
KLF2 Kruppel-like factor 2
KREMEN2 kringle containing transmembrane protein 2
KRI1 KRI1 homolog (S. cerevisiae)
LRP3 low density lipoprotein receptor-related protein 3
METTL16 methyltransferase like 16
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MSL1 male-specific lethal 1 homolog (Drosophila)
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MYO1E myosin IE
NKRF NFKB repressing factor
NLRX1 NLR family member X1
PLEKHO2 pleckstrin homology domain containing, family O member 2
POLE polymerase (DNA directed), epsilon, catalytic subunit
PRICKLE3 prickle homolog 3 (Drosophila)
PRKRIP1 PRKR interacting protein 1 (IL11 inducible)
PRR4 proline rich 4 (lacrimal)
PTDSS2 phosphatidylserine synthase 2
PVRL3 poliovirus receptor-related 3
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RPL10L ribosomal protein L10-like
RPP25 ribonuclease P/MRP 25kDa subunit
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SETD3 SET domain containing 3
SHPK sedoheptulokinase
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLC46A3 solute carrier family 46, member 3
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPINK4 serine peptidase inhibitor, Kazal type 4
STRN4 striatin, calmodulin binding protein 4
TFF2 trefoil factor 2
TH tyrosine hydroxylase
TMEM104 transmembrane protein 104
TNS2 tensin 2
TPCN1 two pore segment channel 1
TRAF2 TNF receptor-associated factor 2
TROAP trophinin associated protein
USP36 ubiquitin specific peptidase 36
VGF VGF nerve growth factor inducible
WRAP73 WD repeat containing, antisense to TP73
XKR8 XK, Kell blood group complex subunit-related family, member 8
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
ZBTB48 zinc finger and BTB domain containing 48
ZC3H3 zinc finger CCCH-type containing 3
ZDHHC18 zinc finger, DHHC-type containing 18
ZMAT5 zinc finger, matrin-type 5
ZMYM1 zinc finger, MYM-type 1
ZNF205 zinc finger protein 205
ZNF532 zinc finger protein 532
ZNF639 zinc finger protein 639
ZNF669 zinc finger protein 669
ZSCAN2 zinc finger and SCAN domain containing 2