Prestwick-642-4419 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the Prestwick-642-4419 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7
ADORA1 adenosine A1 receptor
AMN amnion associated transmembrane protein
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
ARTN artemin
ASIC1 acid sensing (proton gated) ion channel 1
ATP10B ATPase, class V, type 10B
BEGAIN brain-enriched guanylate kinase-associated
BEST2 bestrophin 2
BGN biglycan
BTN3A1 butyrophilin, subfamily 3, member A1
C2ORF27A chromosome 2 open reading frame 27A
C3ORF18 chromosome 3 open reading frame 18
C8ORF44 chromosome 8 open reading frame 44
C9ORF9 chromosome 9 open reading frame 9
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1
CADM4 cell adhesion molecule 4
CASP2 caspase 2, apoptosis-related cysteine peptidase
CBX2 chromobox homolog 2
CD86 CD86 molecule
CDC14B cell division cycle 14B
CDKN2A cyclin-dependent kinase inhibitor 2A
CDO1 cysteine dioxygenase type 1
CEACAM21 carcinoembryonic antigen-related cell adhesion molecule 21
CELF2 CUGBP, Elav-like family member 2
CLCN4 chloride channel, voltage-sensitive 4
CLEC3B C-type lectin domain family 3, member B
COL8A2 collagen, type VIII, alpha 2
DBT dihydrolipoamide branched chain transacylase E2
DICER1 dicer 1, ribonuclease type III
DIO2 deiodinase, iodothyronine, type II
DOCK3 dedicator of cytokinesis 3
EFNB3 ephrin-B3
ESR2 estrogen receptor 2 (ER beta)
ETV7 ets variant 7
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit
FGFR2 fibroblast growth factor receptor 2
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GK glycerol kinase
GLS glutaminase
GPER1 G protein-coupled estrogen receptor 1
GPSM3 G-protein signaling modulator 3
GRIA3 glutamate receptor, ionotropic, AMPA 3
GRIP2 glutamate receptor interacting protein 2
HBP1 HMG-box transcription factor 1
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HIST1H2AK histone cluster 1, H2ak
HRH1 histamine receptor H1
ICAM1 intercellular adhesion molecule 1
IFNA17 interferon, alpha 17
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITM2C integral membrane protein 2C
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KIFC3 kinesin family member C3
KLF13 Kruppel-like factor 13
KRT16 keratin 16, type I
KRT85 keratin 85, type II
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1
MBNL2 muscleblind-like splicing regulator 2
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MLXIPL MLX interacting protein-like
MN1 meningioma (disrupted in balanced translocation) 1
MX1 MX dynamin-like GTPase 1
MYH14 myosin, heavy chain 14, non-muscle
NDOR1 NADPH dependent diflavin oxidoreductase 1
NEIL1 nei endonuclease VIII-like 1 (E. coli)
NF1 neurofibromin 1
NPPA natriuretic peptide A
NPR2 natriuretic peptide receptor 2
NRL neural retina leucine zipper
OLFM1 olfactomedin 1
OSBPL7 oxysterol binding protein-like 7
PCDH11X protocadherin 11 X-linked
PCDHB11 protocadherin beta 11
PDE4C phosphodiesterase 4C, cAMP-specific
PDE4DIP phosphodiesterase 4D interacting protein
PDIA2 protein disulfide isomerase family A, member 2
PGK2 phosphoglycerate kinase 2
PON1 paraoxonase 1
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RUNX1 runt-related transcription factor 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFTPB surfactant protein B
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
STAB2 stabilin 2
SULT4A1 sulfotransferase family 4A, member 1
SWAP70 SWAP switching B-cell complex 70kDa subunit
TBX10 T-box 10
TBX3 T-box 3
THEMIS2 thymocyte selection associated family member 2
TSPAN9 tetraspanin 9
TUBA3C tubulin, alpha 3c
WDR78 WD repeat domain 78
ZER1 zyg-11 related, cell cycle regulator
ZNF362 zinc finger protein 362
ZNF493 zinc finger protein 493
ZNF821 zinc finger protein 821

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8
AOC2 amine oxidase, copper containing 2 (retina-specific)
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
BTF3P11 basic transcription factor 3 pseudogene 11
BTF3P12 basic transcription factor 3 pseudogene 12
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDK3 cyclin-dependent kinase 3
CEACAM4 carcinoembryonic antigen-related cell adhesion molecule 4
CLSTN2 calsyntenin 2
CRIP1 cysteine-rich protein 1 (intestinal)
CRYGC crystallin, gamma C
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DGKQ diacylglycerol kinase, theta 110kDa
DSC3 desmocollin 3
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EDAR ectodysplasin A receptor
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
ERCC2 excision repair cross-complementation group 2
ETAA1 Ewing tumor-associated antigen 1
ETNK2 ethanolamine kinase 2
FAM120C family with sequence similarity 120C
FANCE Fanconi anemia, complementation group E
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GK2 glycerol kinase 2
GLTSCR1 glioma tumor suppressor candidate region gene 1
GMPR guanosine monophosphate reductase
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
GPR27 G protein-coupled receptor 27
HIST1H3G histone cluster 1, H3g
HOXC8 homeobox C8
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
HYAL3 hyaluronoglucosaminidase 3
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IQCC IQ motif containing C
IQSEC2 IQ motif and Sec7 domain 2
ITGA10 integrin, alpha 10
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
LAMP3 lysosomal-associated membrane protein 3
LMNB1 lamin B1
LRP5L low density lipoprotein receptor-related protein 5-like
LZTR1 leucine-zipper-like transcription regulator 1
MGC12488
MLLT4-AS1 MLLT4 antisense RNA 1 (head to head)
MRPL41 mitochondrial ribosomal protein L41
MUC3A mucin 3A, cell surface associated
MX2 MX dynamin-like GTPase 2
NEUROD1 neuronal differentiation 1
NPY4R neuropeptide Y receptor Y4
NXPH4 neurexophilin 4
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OR1D2 olfactory receptor, family 1, subfamily D, member 2
PADI3 peptidyl arginine deiminase, type III
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PDZD2 PDZ domain containing 2
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
PODNL1 podocan-like 1
PRICKLE3 prickle homolog 3 (Drosophila)
RAB40C RAB40C, member RAS oncogene family
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
REM1 RAS (RAD and GEM)-like GTP-binding 1
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RORC RAR-related orphan receptor C
SCN10A sodium channel, voltage gated, type X alpha subunit
SEC14L5 SEC14-like 5 (S. cerevisiae)
SH2B3 SH2B adaptor protein 3
SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SNTA1 syntrophin, alpha 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
STRA6 stimulated by retinoic acid 6
TCEAL2 transcription elongation factor A (SII)-like 2
TCTN1 tectonic family member 1
TPCN1 two pore segment channel 1
TPSG1 tryptase gamma 1
TPST2 tyrosylprotein sulfotransferase 2
TRIM21 tripartite motif containing 21
TRIM36 tripartite motif containing 36
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TTLL1 tubulin tyrosine ligase-like family member 1
USP27X ubiquitin specific peptidase 27, X-linked
WFDC2 WAP four-disulfide core domain 2
YY2 YY2 transcription factor
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZFHX2 zinc finger homeobox 2
ZNF506 zinc finger protein 506