Prestwick-642-4594 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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195 genes differentially expressed following the Prestwick-642-4594 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACSBG1 acyl-CoA synthetase bubblegum family member 1
ACSM3 acyl-CoA synthetase medium-chain family member 3
ADAM23 ADAM metallopeptidase domain 23
AR androgen receptor
BATF basic leucine zipper transcription factor, ATF-like
BBC3 BCL2 binding component 3
BEX1 brain expressed, X-linked 1
BTNL2 butyrophilin-like 2
C1QTNF3 C1q and tumor necrosis factor related protein 3
C8ORF4 chromosome 8 open reading frame 4
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit
CASP2 caspase 2, apoptosis-related cysteine peptidase
CCDC82 coiled-coil domain containing 82
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CREM cAMP responsive element modulator
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
CYP2A7 cytochrome P450, family 2, subfamily A, polypeptide 7
DHODH dihydroorotate dehydrogenase (quinone)
EFR3B EFR3 homolog B (S. cerevisiae)
EGFL7 EGF-like-domain, multiple 7
ESRRG estrogen-related receptor gamma
ETV1 ets variant 1
F13A1 coagulation factor XIII, A1 polypeptide
FAM63B family with sequence similarity 63, member B
FSHB follicle stimulating hormone, beta polypeptide
GIF gastric intrinsic factor (vitamin B synthesis)
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GRIK5 glutamate receptor, ionotropic, kainate 5
GRM8 glutamate receptor, metabotropic 8
HIPK3 homeodomain interacting protein kinase 3
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HLF hepatic leukemia factor
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IL18RAP interleukin 18 receptor accessory protein
IL36RN interleukin 36 receptor antagonist
ING4 inhibitor of growth family, member 4
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KYNU kynureninase
LATS1 large tumor suppressor kinase 1
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
LRRK1 leucine-rich repeat kinase 1
MBD2 methyl-CpG binding domain protein 2
MET MET proto-oncogene, receptor tyrosine kinase
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MMP11 matrix metallopeptidase 11
MOBP myelin-associated oligodendrocyte basic protein
MRPS18C mitochondrial ribosomal protein S18C
MYO1B myosin IB
MYOZ1 myozenin 1
NAAA N-acylethanolamine acid amidase
NCBP1 nuclear cap binding protein subunit 1, 80kDa
NEK9 NIMA-related kinase 9
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NPTX1 neuronal pentraxin I
NTF3 neurotrophin 3
NUP160 nucleoporin 160kDa
OPRM1 opioid receptor, mu 1
PADI1 peptidyl arginine deiminase, type I
PDE4D phosphodiesterase 4D, cAMP-specific
PGLYRP4 peptidoglycan recognition protein 4
PICALM phosphatidylinositol binding clathrin assembly protein
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PNPLA3 patatin-like phospholipase domain containing 3
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha
PRAF2 PRA1 domain family, member 2
PRDM14 PR domain containing 14
PRKCE protein kinase C, epsilon
PTRF polymerase I and transcript release factor
RNF146 ring finger protein 146
RPL10 ribosomal protein L10
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SAP30 Sin3A-associated protein, 30kDa
SC5D sterol-C5-desaturase
SCARF1 scavenger receptor class F, member 1
SCN2A sodium channel, voltage gated, type II alpha subunit
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5
SLC44A1 solute carrier family 44 (choline transporter), member 1
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
STS steroid sulfatase (microsomal), isozyme S
SYT2 synaptotagmin II
TEF thyrotrophic embryonic factor
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLR4 toll-like receptor 4
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TRIM3 tripartite motif containing 3
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast)
VCL vinculin
WT1 Wilms tumor 1
ZNF506 zinc finger protein 506
ZNF549 zinc finger protein 549
ZNF778 zinc finger protein 778

decreased expression

Symbol Name
ADGRB2 adhesion G protein-coupled receptor B2
ADGRG2 adhesion G protein-coupled receptor G2
AGO1 argonaute RISC catalytic component 1
ALG12 ALG12, alpha-1,6-mannosyltransferase
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BAHCC1 BAH domain and coiled-coil containing 1
BMP15 bone morphogenetic protein 15
BOLA1 bolA family member 1
C14ORF93 chromosome 14 open reading frame 93
C19ORF40 chromosome 19 open reading frame 40
C1S complement component 1, s subcomponent
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CDH7 cadherin 7, type 2
CDIP1 cell death-inducing p53 target 1
CEL carboxyl ester lipase
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CLIP2 CAP-GLY domain containing linker protein 2
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
COL9A2 collagen, type IX, alpha 2
CPA4 carboxypeptidase A4
CREB5 cAMP responsive element binding protein 5
CSF1R colony stimulating factor 1 receptor
DTX2 deltex 2, E3 ubiquitin ligase
EDIL3 EGF-like repeats and discoidin I-like domains 3
EGF epidermal growth factor
ELAVL3 ELAV like neuron-specific RNA binding protein 3
ELP6 elongator acetyltransferase complex subunit 6
EYA4 EYA transcriptional coactivator and phosphatase 4
FAM120C family with sequence similarity 120C
FBXW12 F-box and WD repeat domain containing 12
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOXC1 forkhead box C1
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GUSBP3 glucuronidase, beta pseudogene 3
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIST1H4A histone cluster 1, H4a
HOOK1 hook microtubule-tethering protein 1
HOXC4 homeobox C4
HYI hydroxypyruvate isomerase (putative)
KIAA0556 KIAA0556
KIAA0894 KIAA0894 protein
KIAA1107 KIAA1107
KIAA1462 KIAA1462
KLHL26 kelch-like family member 26
LIMS2 LIM and senescent cell antigen-like domains 2
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LRP3 low density lipoprotein receptor-related protein 3
MAGEF1 melanoma antigen family F1
MEGF8 multiple EGF-like-domains 8
MX1 MX dynamin-like GTPase 1
NABP1 nucleic acid binding protein 1
NOTCH1 notch 1
ODF2 outer dense fiber of sperm tails 2
PACS1 phosphofurin acidic cluster sorting protein 1
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PLA2G15 phospholipase A2, group XV
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
POM121 POM121 transmembrane nucleoporin
PRR4 proline rich 4 (lacrimal)
PRSS53 protease, serine, 53
PSKH1 protein serine kinase H1
RANBP17 RAN binding protein 17
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RHOBTB2 Rho-related BTB domain containing 2
ROM1 retinal outer segment membrane protein 1
RPH3AL rabphilin 3A-like (without C2 domains)
RUSC2 RUN and SH3 domain containing 2
RWDD2A RWD domain containing 2A
SAMD9 sterile alpha motif domain containing 9
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SMR3A submaxillary gland androgen regulated protein 3A
SPEG SPEG complex locus
SPIDR scaffolding protein involved in DNA repair
STARD3 StAR-related lipid transfer (START) domain containing 3
STON1 stonin 1
STRN4 striatin, calmodulin binding protein 4
TAOK1 TAO kinase 1
TRIM32 tripartite motif containing 32
TSPAN2 tetraspanin 2
TUBA3C tubulin, alpha 3c
VGF VGF nerve growth factor inducible
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial
ZNF205 zinc finger protein 205
ZNF214 zinc finger protein 214
ZNF611 zinc finger protein 611
ZNF623 zinc finger protein 623
ZNF747 zinc finger protein 747
ZNF76 zinc finger protein 76
ZNF821 zinc finger protein 821
ZNF839 zinc finger protein 839