Prestwick-664-2178 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the Prestwick-664-2178 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4
ACBD4 acyl-CoA binding domain containing 4
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2
ATP10A ATPase, class V, type 10A
B9D1 B9 protein domain 1
BDNF brain-derived neurotrophic factor
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
C1ORF68 chromosome 1 open reading frame 68
C21ORF2 chromosome 21 open reading frame 2
CA6 carbonic anhydrase VI
CACFD1 calcium channel flower domain containing 1
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CCDC40 coiled-coil domain containing 40
CCL22 chemokine (C-C motif) ligand 22
CD24 CD24 molecule
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2
CDH8 cadherin 8, type 2
CIZ1 CDKN1A interacting zinc finger protein 1
CNGB3 cyclic nucleotide gated channel beta 3
CSNK1G1 casein kinase 1, gamma 1
DAPK3 death-associated protein kinase 3
DCAKD dephospho-CoA kinase domain containing
DGKI diacylglycerol kinase, iota
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
EHD1 EH-domain containing 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPHB1 EPH receptor B1
EXPH5 exophilin 5
FABP3 fatty acid binding protein 3, muscle and heart
FAM163A family with sequence similarity 163, member A
FSCN3 fascin actin-bundling protein 3, testicular
GLRX3 glutaredoxin 3
GPLD1 glycosylphosphatidylinositol specific phospholipase D1
GRIP2 glutamate receptor interacting protein 2
GRM1 glutamate receptor, metabotropic 1
GUK1 guanylate kinase 1
HNF1B HNF1 homeobox B
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma
INSL4 insulin-like 4 (placenta)
IQCE IQ motif containing E
IRF6 interferon regulatory factor 6
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
JPH3 junctophilin 3
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KHK ketohexokinase (fructokinase)
LAMP1 lysosomal-associated membrane protein 1
LARS2 leucyl-tRNA synthetase 2, mitochondrial
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LRRC37BP1 leucine rich repeat containing 37B pseudogene 1
MCM3AP minichromosome maintenance complex component 3 associated protein
MECOM MDS1 and EVI1 complex locus
MET MET proto-oncogene, receptor tyrosine kinase
MISP mitotic spindle positioning
MMP13 matrix metallopeptidase 13
MUC8 mucin 8
MXRA8 matrix-remodelling associated 8
NCAPH2 non-SMC condensin II complex, subunit H2
NCR2 natural cytotoxicity triggering receptor 2
ONECUT1 one cut homeobox 1
OXCT2 3-oxoacid CoA transferase 2
PDE4DIP phosphodiesterase 4D interacting protein
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PDE8B phosphodiesterase 8B
PDGFB platelet-derived growth factor beta polypeptide
PLAT plasminogen activator, tissue
PRMT8 protein arginine methyltransferase 8
PTCRA pre T-cell antigen receptor alpha
PTGDR2 prostaglandin D2 receptor 2
PTK7 protein tyrosine kinase 7 (inactive)
PTPRM protein tyrosine phosphatase, receptor type, M
QPCTL glutaminyl-peptide cyclotransferase-like
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
REC8 REC8 meiotic recombination protein
REPS2 RALBP1 associated Eps domain containing 2
RGS12 regulator of G-protein signaling 12
SARDH sarcosine dehydrogenase
SELPLG selectin P ligand
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SIT1 signaling threshold regulating transmembrane adaptor 1
SIX2 SIX homeobox 2
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC35A2 solute carrier family 35 (UDP-galactose transporter), member A2
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SPN sialophorin
SPTBN1 spectrin, beta, non-erythrocytic 1
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
T T, brachyury homolog (mouse)
TBXA2R thromboxane A2 receptor
TCF4 transcription factor 4
TJAP1 tight junction associated protein 1 (peripheral)
TRPV5 transient receptor potential cation channel, subfamily V, member 5
TTLL4 tubulin tyrosine ligase-like family member 4
UBA6 ubiquitin-like modifier activating enzyme 6
WNT2 wingless-type MMTV integration site family member 2
ZNF276 zinc finger protein 276
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ACP6 acid phosphatase 6, lysophosphatidic
ACPP acid phosphatase, prostate
ADGRG2 adhesion G protein-coupled receptor G2
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
APOL6 apolipoprotein L, 6
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BIK BCL2-interacting killer (apoptosis-inducing)
BRIP1 BRCA1 interacting protein C-terminal helicase 1
BTD biotinidase
C16ORF59 chromosome 16 open reading frame 59
C17ORF53 chromosome 17 open reading frame 53
CAND2 cullin-associated and neddylation-dissociated 2 (putative)
CDR2L cerebellar degeneration-related protein 2-like
CEL carboxyl ester lipase
CEP170B centrosomal protein 170B
CEP97 centrosomal protein 97kDa
CHMP1A charged multivesicular body protein 1A
CHMP6 charged multivesicular body protein 6
CREB3 cAMP responsive element binding protein 3
CRELD1 cysteine-rich with EGF-like domains 1
CTNNBIP1 catenin, beta interacting protein 1
DENND5B DENN/MADD domain containing 5B
DHRS7B dehydrogenase/reductase (SDR family) member 7B
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24
DNAL4 dynein, axonemal, light chain 4
DNMBP dynamin binding protein
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FBXW4P1 F-box and WD repeat domain containing 4 pseudogene 1
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)
FKBP9 FK506 binding protein 9, 63 kDa
FMO4 flavin containing monooxygenase 4
FMOD fibromodulin
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GID4 GID complex subunit 4
GNG7 guanine nucleotide binding protein (G protein), gamma 7
HCFC2 host cell factor C2
HIST1H2AJ histone cluster 1, H2aj
HIST1H2BC histone cluster 1, H2bc
HIST1H4D histone cluster 1, H4d
ICK intestinal cell (MAK-like) kinase
IDI2-AS1 IDI2 antisense RNA 1
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KIAA0355 KIAA0355
KIAA1107 KIAA1107
KLHL12 kelch-like family member 12
LMNB2 lamin B2
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
LRRC20 leucine rich repeat containing 20
LY96 lymphocyte antigen 96
MCOLN1 mucolipin 1
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
MICALL2 MICAL-like 2
NCS1 neuronal calcium sensor 1
NIPAL2 NIPA-like domain containing 2
OR1D2 olfactory receptor, family 1, subfamily D, member 2
PAQR6 progestin and adipoQ receptor family member VI
PDLIM2 PDZ and LIM domain 2 (mystique)
PDZD7 PDZ domain containing 7
PER3 period circadian clock 3
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PKN1 protein kinase N1
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PNOC prepronociceptin
POLL polymerase (DNA directed), lambda
POR P450 (cytochrome) oxidoreductase
PRSS12 protease, serine, 12 (neurotrypsin, motopsin)
PTDSS2 phosphatidylserine synthase 2
QTRT1 queuine tRNA-ribosyltransferase 1
RAB3A RAB3A, member RAS oncogene family
RAD54L2 RAD54-like 2 (S. cerevisiae)
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
SALL2 spalt-like transcription factor 2
SETD1A SET domain containing 1A
SIL1 SIL1 nucleotide exchange factor
SLC15A3 solute carrier family 15 (oligopeptide transporter), member 3
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SNX15 sorting nexin 15
SPAG1 sperm associated antigen 1
ST8SIA5 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
STX11 syntaxin 11
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
SUSD6 sushi domain containing 6
TESK1 testis-specific kinase 1
TMEM242 transmembrane protein 242
TRAF1 TNF receptor-associated factor 1
TRIM36 tripartite motif containing 36
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene)
UBXN6 UBX domain protein 6
UNC119 unc-119 homolog (C. elegans)
ZFAND3 zinc finger, AN1-type domain 3
ZFYVE16 zinc finger, FYVE domain containing 16
ZNF254 zinc finger protein 254
ZNF528 zinc finger protein 528
ZNF8 zinc finger protein 8