Prestwick-664-3715 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the Prestwick-664-3715 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACVR1B activin A receptor, type IB
ADAM22 ADAM metallopeptidase domain 22
ADCY1 adenylate cyclase 1 (brain)
AIF1 allograft inflammatory factor 1
AKAP8L A kinase (PRKA) anchor protein 8-like
ANK1 ankyrin 1, erythrocytic
ANXA10 annexin A10
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
ARTN artemin
ATG10 autophagy related 10
BMP7 bone morphogenetic protein 7
BST1 bone marrow stromal cell antigen 1
C18ORF25 chromosome 18 open reading frame 25
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCL16 chemokine (C-C motif) ligand 16
CCL27 chemokine (C-C motif) ligand 27
CD58 CD58 molecule
CDHR2 cadherin-related family member 2
CEP250 centrosomal protein 250kDa
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)
CLTCL1 clathrin, heavy chain-like 1
COMT catechol-O-methyltransferase
CYLC2 cylicin, basic protein of sperm head cytoskeleton 2
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
DAPK1 death-associated protein kinase 1
DDR2 discoidin domain receptor tyrosine kinase 2
DMPK dystrophia myotonica-protein kinase
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DOPEY2 dopey family member 2
DTNA dystrobrevin, alpha
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2
EGR1 early growth response 1
ESR1 estrogen receptor 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
EXOSC2 exosome component 2
FCF1 FCF1 rRNA-processing protein
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGF22 fibroblast growth factor 22
FGF6 fibroblast growth factor 6
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
HAB1 B1 for mucin
HEXA hexosaminidase A (alpha polypeptide)
HKDC1 hexokinase domain containing 1
HLA-DOA major histocompatibility complex, class II, DO alpha
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
IFI44 interferon-induced protein 44
IGHA1 immunoglobulin heavy constant alpha 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
JAM2 junctional adhesion molecule 2
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3
KIAA1109 KIAA1109
KIF24 kinesin family member 24
KLK13 kallikrein-related peptidase 13
LATS1 large tumor suppressor kinase 1
LIPG lipase, endothelial
LRAT lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)
LRRK1 leucine-rich repeat kinase 1
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2
MRC2 mannose receptor, C type 2
MST1L macrophage stimulating 1-like
NAV3 neuron navigator 3
NNAT neuronatin
NR4A1 nuclear receptor subfamily 4, group A, member 1
NRP1 neuropilin 1
NRP2 neuropilin 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OR1F1 olfactory receptor, family 1, subfamily F, member 1
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
POU2F2 POU class 2 homeobox 2
PRDX2 peroxiredoxin 2
PRKCE protein kinase C, epsilon
PTPRJ protein tyrosine phosphatase, receptor type, J
RABEP1 rabaptin, RAB GTPase binding effector protein 1
RASA3 RAS p21 protein activator 3
RDH16 retinol dehydrogenase 16 (all-trans)
RGS5 regulator of G-protein signaling 5
RHAG Rh-associated glycoprotein
RNF6 ring finger protein (C3H2C3 type) 6
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SEC14L4 SEC14-like 4 (S. cerevisiae)
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
SFTPB surfactant protein B
SPACA1 sperm acrosome associated 1
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SRRT serrate, RNA effector molecule
SYCE1L synaptonemal complex central element protein 1-like
TACSTD2 tumor-associated calcium signal transducer 2
TAOK2 TAO kinase 2
TBX1 T-box 1
TET3 tet methylcytosine dioxygenase 3
TMEM212 transmembrane protein 212
TRIM2 tripartite motif containing 2
TUBA3C tubulin, alpha 3c
WNT16 wingless-type MMTV integration site family, member 16
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF287 zinc finger protein 287
ZSWIM1 zinc finger, SWIM-type containing 1

decreased expression

Symbol Name
AK5 adenylate kinase 5
ALPP alkaline phosphatase, placental
AMDHD2 amidohydrolase domain containing 2
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
BIRC7 baculoviral IAP repeat containing 7
BTC betacellulin
C1RL complement component 1, r subcomponent-like
C5ORF45 chromosome 5 open reading frame 45
C6ORF47 chromosome 6 open reading frame 47
CASZ1 castor zinc finger 1
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CCDC7 coiled-coil domain containing 7
CCDC9 coiled-coil domain containing 9
CCNO cyclin O
CIDEC cell death-inducing DFFA-like effector c
CLCA1 chloride channel accessory 1
CLCN6 chloride channel, voltage-sensitive 6
CLSTN3 calsyntenin 3
CNIH3 cornichon family AMPA receptor auxiliary protein 3
CNPY4 canopy FGF signaling regulator 4
CPED1 cadherin-like and PC-esterase domain containing 1
DAGLA diacylglycerol lipase, alpha
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DZANK1 double zinc ribbon and ankyrin repeat domains 1
EDN1 endothelin 1
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
ELAVL3 ELAV like neuron-specific RNA binding protein 3
ERN2 endoplasmic reticulum to nucleus signaling 2
FANCC Fanconi anemia, complementation group C
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GTF2I general transcription factor IIi
HIST1H3C histone cluster 1, H3c
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IL11RA interleukin 11 receptor, alpha
IL2 interleukin 2
ING4 inhibitor of growth family, member 4
IRF1 interferon regulatory factor 1
KCNMB4 potassium channel subfamily M regulatory beta subunit 4
KLF3 Kruppel-like factor 3 (basic)
LIN7B lin-7 homolog B (C. elegans)
LMO7 LIM domain 7
LMTK1 lemur tail kinase 1
LNPEP leucyl/cystinyl aminopeptidase
LOC730101 uncharacterized LOC730101
LRRC61 leucine rich repeat containing 61
MAGEH1 melanoma antigen family H1
MAL mal, T-cell differentiation protein
MANBA mannosidase, beta A, lysosomal
MAP2 microtubule-associated protein 2
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1
MLYCD malonyl-CoA decarboxylase
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MTMR12 myotubularin related protein 12
MYOZ3 myozenin 3
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
NELL2 NEL-like 2 (chicken)
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PAQR5 progestin and adipoQ receptor family member V
PARP3 poly (ADP-ribose) polymerase family, member 3
PAX9 paired box 9
PDZK1 PDZ domain containing 1
PHGDH phosphoglycerate dehydrogenase
PID1 phosphotyrosine interaction domain containing 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLXNB3 plexin B3
PODXL2 podocalyxin-like 2
POLL polymerase (DNA directed), lambda
PRSS22 protease, serine, 22
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
QSER1 glutamine and serine rich 1
RASAL2 RAS protein activator like 2
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
ROM1 retinal outer segment membrane protein 1
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
SGK2 serum/glucocorticoid regulated kinase 2
SIRT6 sirtuin 6
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLC46A3 solute carrier family 46, member 3
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
SYCP2 synaptonemal complex protein 2
TEX15 testis expressed 15
THNSL1 threonine synthase-like 1 (S. cerevisiae)
TMEM74B transmembrane protein 74B
TMSB15A thymosin beta 15a
TRAF3IP2 TRAF3 interacting protein 2
TSNAXIP1 translin-associated factor X interacting protein 1
TTC30A tetratricopeptide repeat domain 30A
WDR25 WD repeat domain 25
ZFHX2 zinc finger homeobox 2
ZNF137P zinc finger protein 137, pseudogene
ZNF358 zinc finger protein 358
ZNF516 zinc finger protein 516