Prestwick-664-4275 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the Prestwick-664-4275 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAN aggrecan
ADAM12 ADAM metallopeptidase domain 12
AFF1 AF4/FMR2 family, member 1
AIM1L absent in melanoma 1-like
AKAP1 A kinase (PRKA) anchor protein 1
APCS amyloid P component, serum
AQP4 aquaporin 4
AQP6 aquaporin 6, kidney specific
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BMPR1B bone morphogenetic protein receptor, type IB
C10ORF12 chromosome 10 open reading frame 12
C3AR1 complement component 3a receptor 1
C8B complement component 8, beta polypeptide
CACYBP calcyclin binding protein
CATSPERG catsper channel auxiliary subunit gamma
CCDC40 coiled-coil domain containing 40
CIB2 calcium and integrin binding family member 2
CLEC3B C-type lectin domain family 3, member B
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CRHR1 corticotropin releasing hormone receptor 1
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
CUL3 cullin 3
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DOCK5 dedicator of cytokinesis 5
DUSP7 dual specificity phosphatase 7
EFHC2 EF-hand domain (C-terminal) containing 2
ELL2 elongation factor, RNA polymerase II, 2
EMC3 ER membrane protein complex subunit 3
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
ERC2 ELKS/RAB6-interacting/CAST family member 2
ERN2 endoplasmic reticulum to nucleus signaling 2
FOXO4 forkhead box O4
GJA4 gap junction protein, alpha 4, 37kDa
GK glycerol kinase
GPR137 G protein-coupled receptor 137
GYPC glycophorin C (Gerbich blood group)
HESX1 HESX homeobox 1
HIST1H2AL histone cluster 1, H2al
HMGB3P1 high mobility group box 3 pseudogene 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IDS iduronate 2-sulfatase
IGKV1D-13 immunoglobulin kappa variable 1D-13
IGL immunoglobulin lambda locus
IRF4 interferon regulatory factor 4
KITLG KIT ligand
KRT86 keratin 86, type II
LATS1 large tumor suppressor kinase 1
LRRC31 leucine rich repeat containing 31
MAN1C1 mannosidase, alpha, class 1C, member 1
MAPK14 mitogen-activated protein kinase 14
MAPRE3 microtubule-associated protein, RP/EB family, member 3
MERTK MER proto-oncogene, tyrosine kinase
MORN1 MORN repeat containing 1
NEBL nebulette
NEK1 NIMA-related kinase 1
OASL 2'-5'-oligoadenylate synthetase-like
OPN1SW opsin 1 (cone pigments), short-wave-sensitive
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PRAMEF12 PRAME family member 12
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTPRR protein tyrosine phosphatase, receptor type, R
PVT1 Pvt1 oncogene (non-protein coding)
RARG retinoic acid receptor, gamma
RHO rhodopsin
RIF1 replication timing regulatory factor 1
RIMS3 regulating synaptic membrane exocytosis 3
RRAGD Ras-related GTP binding D
RUNDC3A RUN domain containing 3A
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFTPB surfactant protein B
SH3BP2 SH3-domain binding protein 2
SH3D21 SH3 domain containing 21
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SLCO1C1 solute carrier organic anion transporter family, member 1C1
SOCS7 suppressor of cytokine signaling 7
SORCS3 sortilin-related VPS10 domain containing receptor 3
SOX2 SRY (sex determining region Y)-box 2
SRF serum response factor (c-fos serum response element-binding transcription factor)
STAB2 stabilin 2
STMN3 stathmin-like 3
SYNDIG1 synapse differentiation inducing 1
TACR1 tachykinin receptor 1
TCN2 transcobalamin II
THBS1 thrombospondin 1
THEMIS2 thymocyte selection associated family member 2
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18
TNNT2 troponin T type 2 (cardiac)
TRBV10-2 T cell receptor beta variable 10-2
TRIM25 tripartite motif containing 25
TRPM3 transient receptor potential cation channel, subfamily M, member 3
TULP2 tubby like protein 2
VCAN versican
WASL Wiskott-Aldrich syndrome-like
ZIM2 zinc finger, imprinted 2
ZNF407 zinc finger protein 407

decreased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ADAP2 ArfGAP with dual PH domains 2
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ANOS1 anosmin 1
ANP32A-IT1 ANP32A intronic transcript 1
APOL6 apolipoprotein L, 6
ATF7IP2 activating transcription factor 7 interacting protein 2
BCAS3 breast carcinoma amplified sequence 3
BEX1 brain expressed, X-linked 1
C11ORF63 chromosome 11 open reading frame 63
C11ORF80 chromosome 11 open reading frame 80
C1S complement component 1, s subcomponent
CA11 carbonic anhydrase XI
CA5BP1 carbonic anhydrase VB pseudogene 1
CCNO cyclin O
CD70 CD70 molecule
CDADC1 cytidine and dCMP deaminase domain containing 1
CLEC4E C-type lectin domain family 4, member E
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CORT cortistatin
CRMP1 collapsin response mediator protein 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DENND3 DENN/MADD domain containing 3
DOCK1 dedicator of cytokinesis 1
ELP6 elongator acetyltransferase complex subunit 6
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
EPN3 epsin 3
ERCC2 excision repair cross-complementation group 2
FAM50B family with sequence similarity 50, member B
FBXO31 F-box protein 31
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FGF23 fibroblast growth factor 23
FURIN furin (paired basic amino acid cleaving enzyme)
GAMT guanidinoacetate N-methyltransferase
GLS2 glutaminase 2 (liver, mitochondrial)
GMPR guanosine monophosphate reductase
H2AFJ H2A histone family, member J
HDHD3 haloacid dehalogenase-like hydrolase domain containing 3
HHLA3 HERV-H LTR-associating 3
HIST1H3F histone cluster 1, H3f
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8
IDI2-AS1 IDI2 antisense RNA 1
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IFNAR1 interferon (alpha, beta and omega) receptor 1
INF2 inverted formin, FH2 and WH2 domain containing
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KIAA0319L KIAA0319-like
KLHL3 kelch-like family member 3
KLHL36 kelch-like family member 36
KLRG1 killer cell lectin-like receptor subfamily G, member 1
KRT6A keratin 6A, type II
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LYRM9 LYR motif containing 9
MED31 mediator complex subunit 31
MMP3 matrix metallopeptidase 3
NME3 NME/NM23 nucleoside diphosphate kinase 3
NTSR1 neurotensin receptor 1 (high affinity)
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PARD6A par-6 family cell polarity regulator alpha
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PGPEP1 pyroglutamyl-peptidase I
PHF14 PHD finger protein 14
PHGDH phosphoglycerate dehydrogenase
PIEZO1 piezo-type mechanosensitive ion channel component 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLEKHO1 pleckstrin homology domain containing, family O member 1
PODNL1 podocan-like 1
POLL polymerase (DNA directed), lambda
PRKX protein kinase, X-linked
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
RAD54L RAD54-like (S. cerevisiae)
RPAIN RPA interacting protein
SCN1B sodium channel, voltage gated, type I beta subunit
SLC44A1 solute carrier family 44 (choline transporter), member 1
SLC46A3 solute carrier family 46, member 3
SLC4A3 solute carrier family 4 (anion exchanger), member 3
SPTBN2 spectrin, beta, non-erythrocytic 2
STARD3 StAR-related lipid transfer (START) domain containing 3
TBXAS1 thromboxane A synthase 1 (platelet)
TEP1 telomerase-associated protein 1
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TH tyrosine hydroxylase
THBS3 thrombospondin 3
TIAM2 T-cell lymphoma invasion and metastasis 2
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TOR4A torsin family 4, member A
TRAF2 TNF receptor-associated factor 2
TRAPPC6A trafficking protein particle complex 6A
UNC119 unc-119 homolog (C. elegans)
ZC2HC1C zinc finger, C2HC-type containing 1C
ZFHX2 zinc finger homeobox 2
ZNF219 zinc finger protein 219
ZNF276 zinc finger protein 276
ZNF428 zinc finger protein 428
ZNF606 zinc finger protein 606