Prestwick-665-6041 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the Prestwick-665-6041 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AASS aminoadipate-semialdehyde synthase
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ADGRG1 adhesion G protein-coupled receptor G1
AMPD3 adenosine monophosphate deaminase 3
ASIC2 acid sensing (proton gated) ion channel 2
ASPN asporin
B3GNTL1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1
BIN1 bridging integrator 1
BTF3P11 basic transcription factor 3 pseudogene 11
C14ORF1 chromosome 14 open reading frame 1
C17ORF53 chromosome 17 open reading frame 53
CABP2 calcium binding protein 2
CASP10 caspase 10, apoptosis-related cysteine peptidase
CASP5 caspase 5, apoptosis-related cysteine peptidase
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3
CEND1 cell cycle exit and neuronal differentiation 1
CIDEB cell death-inducing DFFA-like effector b
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CST4 cystatin S
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
EPX eosinophil peroxidase
EPYC epiphycan
EXOSC2 exosome component 2
FAM120C family with sequence similarity 120C
FAM182B family with sequence similarity 182, member B
FCAR Fc fragment of IgA receptor
FGF17 fibroblast growth factor 17
FGF4 fibroblast growth factor 4
FGF6 fibroblast growth factor 6
FLJ11292
FRMPD1 FERM and PDZ domain containing 1
GAP43 growth associated protein 43
GCNT4 glucosaminyl (N-acetyl) transferase 4, core 2
GRK4 G protein-coupled receptor kinase 4
GRM8 glutamate receptor, metabotropic 8
GTPBP1 GTP binding protein 1
HOXD10 homeobox D10
HR hair growth associated
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IGHA1 immunoglobulin heavy constant alpha 1
IGLV3-19 immunoglobulin lambda variable 3-19
IL16 interleukin 16
INHBA inhibin, beta A
KALRN kalirin, RhoGEF kinase
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KRT14 keratin 14, type I
LAIR1 leukocyte-associated immunoglobulin-like receptor 1
LBX1 ladybird homeobox 1
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LRRC48 leucine rich repeat containing 48
MAPRE3 microtubule-associated protein, RP/EB family, member 3
MBD2 methyl-CpG binding domain protein 2
MECOM MDS1 and EVI1 complex locus
METTL7A methyltransferase like 7A
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MXD4 MAX dimerization protein 4
NAG18 NAG18 mRNA
OBSL1 obscurin-like 1
OPCML opioid binding protein/cell adhesion molecule-like
PARP8 poly (ADP-ribose) polymerase family, member 8
PAX3 paired box 3
PAX8 paired box 8
PCDHB17P protocadherin beta 17 pseudogene
PDE11A phosphodiesterase 11A
PDE12 phosphodiesterase 12
PDLIM5 PDZ and LIM domain 5
PECAM1 platelet/endothelial cell adhesion molecule 1
PKP1 plakophilin 1
PMFBP1 polyamine modulated factor 1 binding protein 1
POLDIP3 polymerase (DNA-directed), delta interacting protein 3
POU2F2 POU class 2 homeobox 2
PRB1 proline-rich protein BstNI subfamily 1
PROL1 proline rich, lacrimal 1
PTGER3 prostaglandin E receptor 3 (subtype EP3)
RCE1 Ras converting CAAX endopeptidase 1
RGS12 regulator of G-protein signaling 12
RGS14 regulator of G-protein signaling 14
RNF126P1 ring finger protein 126 pseudogene 1
RTN2 reticulon 2
SAMD9 sterile alpha motif domain containing 9
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2
SMR3A submaxillary gland androgen regulated protein 3A
SNTA1 syntrophin, alpha 1
SPATA1 spermatogenesis associated 1
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
SSX1 synovial sarcoma, X breakpoint 1
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6
TAPBP TAP binding protein (tapasin)
TCF3 transcription factor 3
TNNT3 troponin T type 3 (skeletal, fast)
TRAK1 trafficking protein, kinesin binding 1
ZNF223 zinc finger protein 223
ZNF440 zinc finger protein 440

decreased expression

Symbol Name
ACTL8 actin-like 8
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
AKR1C3 aldo-keto reductase family 1, member C3
AP1G2 adaptor-related protein complex 1, gamma 2 subunit
APOLD1 apolipoprotein L domain containing 1
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma
B9D2 B9 protein domain 2
BAG4 BCL2-associated athanogene 4
C1ORF109 chromosome 1 open reading frame 109
C5ORF45 chromosome 5 open reading frame 45
C7ORF43 chromosome 7 open reading frame 43
CAMK1 calcium/calmodulin-dependent protein kinase I
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CCDC186 coiled-coil domain containing 186
CDC73 cell division cycle 73
CHKB choline kinase beta
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
CLCN5 chloride channel, voltage-sensitive 5
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
COPZ2 coatomer protein complex, subunit zeta 2
CRY2 cryptochrome circadian clock 2
CRYBB2P1 crystallin, beta B2 pseudogene 1
CRYL1 crystallin, lambda 1
CST6 cystatin E/M
CTSK cathepsin K
CUZD1 CUB and zona pellucida-like domains 1
DGKE diacylglycerol kinase, epsilon 64kDa
DHDDS dehydrodolichyl diphosphate synthase
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
DMTF1 cyclin D binding myb-like transcription factor 1
DUSP8 dual specificity phosphatase 8
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EHMT1 euchromatic histone-lysine N-methyltransferase 1
ELOVL4 ELOVL fatty acid elongase 4
FOXN2 forkhead box N2
FRS2 fibroblast growth factor receptor substrate 2
GBP2 guanylate binding protein 2, interferon-inducible
GFOD1 glucose-fructose oxidoreductase domain containing 1
GLI3 GLI family zinc finger 3
GPX2 glutathione peroxidase 2
HIST1H2AI histone cluster 1, H2ai
INO80D INO80 complex subunit D
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KLF2 Kruppel-like factor 2
KLHL2 kelch-like family member 2
KLK5 kallikrein-related peptidase 5
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LIG4 ligase IV, DNA, ATP-dependent
LIN37 lin-37 DREAM MuvB core complex component
LMO2 LIM domain only 2 (rhombotin-like 1)
LYPD1 LY6/PLAUR domain containing 1
MAN2C1 mannosidase, alpha, class 2C, member 1
MBNL3 muscleblind-like splicing regulator 3
MBTD1 mbt domain containing 1
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MDM4 MDM4, p53 regulator
N4BP3 NEDD4 binding protein 3
NAA38 N(alpha)-acetyltransferase 38, NatC auxiliary subunit
NOL10 nucleolar protein 10
NR1H3 nuclear receptor subfamily 1, group H, member 3
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
OSGIN1 oxidative stress induced growth inhibitor 1
PCDHA9 protocadherin alpha 9
PGBD5 piggyBac transposable element derived 5
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PPT2 palmitoyl-protein thioesterase 2
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
RBL1 retinoblastoma-like 1
RFTN1 raftlin, lipid raft linker 1
RIT1 Ras-like without CAAX 1
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPGRIP1L RPGRIP1-like
S100A4 S100 calcium binding protein A4
SIRAL2 SIR2 antiphage like 2
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae)
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
SYBU syntabulin (syntaxin-interacting)
TBX19 T-box 19
TFB1M transcription factor B1, mitochondrial
TH tyrosine hydroxylase
TOM1 target of myb1 (chicken)
TPST2 tyrosylprotein sulfotransferase 2
TUBGCP5 tubulin, gamma complex associated protein 5
UBXN8 UBX domain protein 8
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
ZBED1 zinc finger, BED-type containing 1
ZBTB3 zinc finger and BTB domain containing 3
ZBTB48 zinc finger and BTB domain containing 48
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF16 zinc finger protein 16
ZNF34 zinc finger protein 34
ZNF350 zinc finger protein 350
ZNF813 zinc finger protein 813