Prestwick-674-4276 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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194 genes differentially expressed following the Prestwick-674-4276 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A2M alpha-2-macroglobulin
ACACB acetyl-CoA carboxylase beta
ACSBG2 acyl-CoA synthetase bubblegum family member 2
ACTA1 actin, alpha 1, skeletal muscle
ADAM12 ADAM metallopeptidase domain 12
ADGRA2 adhesion G protein-coupled receptor A2
ALDOB aldolase B, fructose-bisphosphate
ANKRD55 ankyrin repeat domain 55
ARHGAP35 Rho GTPase activating protein 35
ATF7IP activating transcription factor 7 interacting protein
ATXN3 ataxin 3
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2
BST1 bone marrow stromal cell antigen 1
CA1 carbonic anhydrase I
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CASZ1 castor zinc finger 1
CD22 CD22 molecule
CEP250 centrosomal protein 250kDa
CHI3L2 chitinase 3-like 2
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
COPE coatomer protein complex, subunit epsilon
CPA3 carboxypeptidase A3 (mast cell)
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
DGKG diacylglycerol kinase, gamma 90kDa
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DSTYK dual serine/threonine and tyrosine protein kinase
DTNA dystrobrevin, alpha
EFHD1 EF-hand domain family, member D1
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
ERN2 endoplasmic reticulum to nucleus signaling 2
FBXO41 F-box protein 41
FRS2 fibroblast growth factor receptor substrate 2
GLS glutaminase
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GPR17 G protein-coupled receptor 17
GPR22 G protein-coupled receptor 22
GREB1L growth regulation by estrogen in breast cancer-like
GYPB glycophorin B (MNS blood group)
HHLA1 HERV-H LTR-associating 1
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2
HNF1A HNF1 homeobox A
HR hair growth associated
IGKV1D-13 immunoglobulin kappa variable 1D-13
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
KCTD14 potassium channel tetramerization domain containing 14
KLHL18 kelch-like family member 18
LAMB4 laminin, beta 4
LARP4B La ribonucleoprotein domain family, member 4B
LDB2 LIM domain binding 2
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
MAP3K13 mitogen-activated protein kinase kinase kinase 13
MAPRE3 microtubule-associated protein, RP/EB family, member 3
MECOM MDS1 and EVI1 complex locus
MOBP myelin-associated oligodendrocyte basic protein
MST1 macrophage stimulating 1
MUC3A mucin 3A, cell surface associated
MYT1 myelin transcription factor 1
N4BP2L1 NEDD4 binding protein 2-like 1
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)
NPTX2 neuronal pentraxin II
NTF3 neurotrophin 3
OR1D2 olfactory receptor, family 1, subfamily D, member 2
OR1G1 olfactory receptor, family 1, subfamily G, member 1
OSBP2 oxysterol binding protein 2
OSBPL10 oxysterol binding protein-like 10
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
PKP4 plakophilin 4
POU6F1 POU class 6 homeobox 1
PRELP proline/arginine-rich end leucine-rich repeat protein
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKCE protein kinase C, epsilon
PRKG1 protein kinase, cGMP-dependent, type I
PVT1 Pvt1 oncogene (non-protein coding)
RAB6A RAB6A, member RAS oncogene family
RARG retinoic acid receptor, gamma
RIMS3 regulating synaptic membrane exocytosis 3
SEC14L5 SEC14-like 5 (S. cerevisiae)
SH3D21 SH3 domain containing 21
SLC16A6 solute carrier family 16, member 6
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SOCS3 suppressor of cytokine signaling 3
SOX30 SRY (sex determining region Y)-box 30
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
SRSF7 serine/arginine-rich splicing factor 7
SUGP1 SURP and G patch domain containing 1
SYCP1 synaptonemal complex protein 1
SYNDIG1 synapse differentiation inducing 1
TAPBP TAP binding protein (tapasin)
TCF4 transcription factor 4
TLK1 tousled-like kinase 1
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TRAF3IP3 TRAF3 interacting protein 3
ZBTB7A zinc finger and BTB domain containing 7A
ZNF141 zinc finger protein 141
ZNF235 zinc finger protein 235
ZNF609 zinc finger protein 609
ZNF93 zinc finger protein 93

decreased expression

Symbol Name
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3
ACOX2 acyl-CoA oxidase 2, branched chain
AFAP1 actin filament associated protein 1
ANKH ANKH inorganic pyrophosphate transport regulator
ARID3B AT rich interactive domain 3B (BRIGHT-like)
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BTC betacellulin
C16ORF59 chromosome 16 open reading frame 59
CA5BP1 carbonic anhydrase VB pseudogene 1
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated
CCDC106 coiled-coil domain containing 106
CCDC132 coiled-coil domain containing 132
CCDC7 coiled-coil domain containing 7
CCNE1 cyclin E1
CDH7 cadherin 7, type 2
CFAP69 cilia and flagella associated protein 69
CLSPN claspin
CNTNAP1 contactin associated protein 1
CRMP1 collapsin response mediator protein 1
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CUL9 cullin 9
DBF4B DBF4 zinc finger B
DLK2 delta-like 2 homolog (Drosophila)
DNAH7 dynein, axonemal, heavy chain 7
EFNB1 ephrin-B1
ELP6 elongator acetyltransferase complex subunit 6
EYA4 EYA transcriptional coactivator and phosphatase 4
FAM120C family with sequence similarity 120C
FAM204A family with sequence similarity 204, member A
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GLS2 glutaminase 2 (liver, mitochondrial)
GLTSCR1 glioma tumor suppressor candidate region gene 1
GMPR guanosine monophosphate reductase
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HLA-DMA major histocompatibility complex, class II, DM alpha
IFNA14 interferon, alpha 14
IL17RA interleukin 17 receptor A
IQCC IQ motif containing C
IQSEC2 IQ motif and Sec7 domain 2
KIAA0319L KIAA0319-like
KLHL25 kelch-like family member 25
KLHL36 kelch-like family member 36
LINC00216 long intergenic non-protein coding RNA 216
LRP3 low density lipoprotein receptor-related protein 3
LRRC6 leucine rich repeat containing 6
LYRM9 LYR motif containing 9
LZTS3 leucine zipper, putative tumor suppressor family member 3
MANBA mannosidase, beta A, lysosomal
MAP3K7CL MAP3K7 C-terminal like
MEIS1 Meis homeobox 1
MOB3B MOB kinase activator 3B
MON1B MON1 secretory trafficking family member B
MTG1 mitochondrial ribosome-associated GTPase 1
MYL5 myosin, light chain 5, regulatory
MYO1F myosin IF
NTSR1 neurotensin receptor 1 (high affinity)
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
ORAI3 ORAI calcium release-activated calcium modulator 3
PALM paralemmin
PGP phosphoglycolate phosphatase
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
POLL polymerase (DNA directed), lambda
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
RASL11B RAS-like, family 11, member B
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RGS17 regulator of G-protein signaling 17
RHBDD3 rhomboid domain containing 3
RPA4 replication protein A4, 30kDa
S100A3 S100 calcium binding protein A3
SCN1B sodium channel, voltage gated, type I beta subunit
SENP7 SUMO1/sentrin specific peptidase 7
SERGEF secretion regulating guanine nucleotide exchange factor
SERTAD3 SERTA domain containing 3
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
TCTN1 tectonic family member 1
TEP1 telomerase-associated protein 1
THAP7 THAP domain containing 7
TIAM2 T-cell lymphoma invasion and metastasis 2
TRMT44 tRNA methyltransferase 44 homolog (S. cerevisiae)
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene)
USP20 ubiquitin specific peptidase 20
VGF VGF nerve growth factor inducible
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
YIPF1 Yip1 domain family, member 1
ZNF222 zinc finger protein 222
ZNF350 zinc finger protein 350
ZNF428 zinc finger protein 428
ZNF667 zinc finger protein 667
ZNF862 zinc finger protein 862