Prestwick-674-4738 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the Prestwick-674-4738 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTN2 actinin, alpha 2
ADORA1 adenosine A1 receptor
AHSP alpha hemoglobin stabilizing protein
AKT3 v-akt murine thymoma viral oncogene homolog 3
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
APOB apolipoprotein B
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BDNF brain-derived neurotrophic factor
BMP10 bone morphogenetic protein 10
BTF3P11 basic transcription factor 3 pseudogene 11
C19ORF66 chromosome 19 open reading frame 66
C1ORF54 chromosome 1 open reading frame 54
C21ORF2 chromosome 21 open reading frame 2
CABP2 calcium binding protein 2
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit
CASP2 caspase 2, apoptosis-related cysteine peptidase
CCDC134 coiled-coil domain containing 134
CCL27 chemokine (C-C motif) ligand 27
CCR7 chemokine (C-C motif) receptor 7
CD86 CD86 molecule
CDRT1 CMT1A duplicated region transcript 1
CNTNAP2 contactin associated protein-like 2
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CPQ carboxypeptidase Q
CRTC1 CREB regulated transcription coactivator 1
CTSF cathepsin F
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR6 chemokine (C-X-C motif) receptor 6
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
EDNRA endothelin receptor type A
EGR1 early growth response 1
FLJ11292
FPR1 formyl peptide receptor 1
GABRQ gamma-aminobutyric acid (GABA) A receptor, theta
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GDNF glial cell derived neurotrophic factor
GPR68 G protein-coupled receptor 68
GRB10 growth factor receptor-bound protein 10
GRM7 glutamate receptor, metabotropic 7
GSK3A glycogen synthase kinase 3 alpha
GSTA4 glutathione S-transferase alpha 4
GSTP1 glutathione S-transferase pi 1
HIC2 hypermethylated in cancer 2
HOXB2 homeobox B2
HOXB3 homeobox B3
IL2RB interleukin 2 receptor, beta
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KLRB1 killer cell lectin-like receptor subfamily B, member 1
LILRA5 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5
LOX lysyl oxidase
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MAPK11 mitogen-activated protein kinase 11
MAPT microtubule-associated protein tau
MARK2 MAP/microtubule affinity-regulating kinase 2
MASP2 mannan-binding lectin serine peptidase 2
MCAM melanoma cell adhesion molecule
MEF2C myocyte enhancer factor 2C
MEG3 maternally expressed 3 (non-protein coding)
MEGF6 multiple EGF-like-domains 6
MTMR1 myotubularin related protein 1
N4BP2L2-IT2 N4BPL2 intronic transcript 2
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NPAS2 neuronal PAS domain protein 2
NPFFR1 neuropeptide FF receptor 1
NPY4R neuropeptide Y receptor Y4
NRF1 nuclear respiratory factor 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
OR2B6 olfactory receptor, family 2, subfamily B, member 6
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDGFC platelet derived growth factor C
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
POU6F1 POU class 6 homeobox 1
PTCRA pre T-cell antigen receptor alpha
PTGDS prostaglandin D2 synthase 21kDa (brain)
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C)
SCN1B sodium channel, voltage gated, type I beta subunit
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SETBP1 SET binding protein 1
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1
SLC43A3 solute carrier family 43, member 3
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SLC9A7 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7
STXBP5L syntaxin binding protein 5-like
SUGP1 SURP and G patch domain containing 1
SYT5 synaptotagmin V
TBC1D2 TBC1 domain family, member 2
TBL2 transducin (beta)-like 2
TBX5 T-box 5
TMBIM1 transmembrane BAX inhibitor motif containing 1
TMCC2 transmembrane and coiled-coil domain family 2
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TRIM22 tripartite motif containing 22

decreased expression

Symbol Name
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12
ACSL4 acyl-CoA synthetase long-chain family member 4
ALPK1 alpha-kinase 1
ALS2CL ALS2 C-terminal like
ANKEF1 ankyrin repeat and EF-hand domain containing 1
ANP32A-IT1 ANP32A intronic transcript 1
ARHGAP11A Rho GTPase activating protein 11A
ARHGAP4 Rho GTPase activating protein 4
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
BAHCC1 BAH domain and coiled-coil containing 1
C2ORF54 chromosome 2 open reading frame 54
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CCDC132 coiled-coil domain containing 132
CCDC186 coiled-coil domain containing 186
CENPO centromere protein O
CEP97 centrosomal protein 97kDa
CES3 carboxylesterase 3
CFD complement factor D (adipsin)
CLCN6 chloride channel, voltage-sensitive 6
CLSPN claspin
CLSTN2 calsyntenin 2
CORO7 coronin 7
CPSF7 cleavage and polyadenylation specific factor 7, 59kDa
CUEDC1 CUE domain containing 1
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DGCR2 DiGeorge syndrome critical region gene 2
DMTN dematin actin binding protein
DOCK4 dedicator of cytokinesis 4
DYSF dysferlin
EXO5 exonuclease 5
FADS2 fatty acid desaturase 2
FKRP fukutin related protein
FLCN folliculin
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GID4 GID complex subunit 4
GINS4 GINS complex subunit 4 (Sld5 homolog)
GRTP1 growth hormone regulated TBC protein 1
GUSBP3 glucuronidase, beta pseudogene 3
HAMP hepcidin antimicrobial peptide
HIST1H2AJ histone cluster 1, H2aj
HIST1H4D histone cluster 1, H4d
HMHA1 histocompatibility (minor) HA-1
HOXA4 homeobox A4
HPN hepsin
ICK intestinal cell (MAK-like) kinase
IREB2 iron-responsive element binding protein 2
KIAA1456 KIAA1456
LY6G6C lymphocyte antigen 6 complex, locus G6C
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MGC12488
MRPL44 mitochondrial ribosomal protein L44
MRPS18C mitochondrial ribosomal protein S18C
MYH9 myosin, heavy chain 9, non-muscle
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
NFS1 NFS1 cysteine desulfurase
NPTX1 neuronal pentraxin I
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
OVOL1 ovo-like zinc finger 1
PAQR3 progestin and adipoQ receptor family member III
PCDHB8 protocadherin beta 8
PDE12 phosphodiesterase 12
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PGR progesterone receptor
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PRSS53 protease, serine, 53
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RBL1 retinoblastoma-like 1
RFTN1 raftlin, lipid raft linker 1
RNF208 ring finger protein 208
RPL23AP32 ribosomal protein L23a pseudogene 32
RRAGB Ras-related GTP binding B
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SMR3A submaxillary gland androgen regulated protein 3A
SPIDR scaffolding protein involved in DNA repair
SRPX sushi-repeat containing protein, X-linked
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TMEM38B transmembrane protein 38B
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TNS2 tensin 2
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TSGA10 testis specific, 10
VIM vimentin
WDR25 WD repeat domain 25
WDR62 WD repeat domain 62
ZBTB3 zinc finger and BTB domain containing 3
ZBTB6 zinc finger and BTB domain containing 6
ZNF141 zinc finger protein 141
ZNF204P zinc finger protein 204, pseudogene
ZNF254 zinc finger protein 254
ZNF286A zinc finger protein 286A
ZNF652 zinc finger protein 652
ZNF747 zinc finger protein 747
ZNF804A zinc finger protein 804A
Funding