Prestwick-674-6034 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the Prestwick-674-6034 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A4GNT alpha-1,4-N-acetylglucosaminyltransferase
AKAP1 A kinase (PRKA) anchor protein 1
AKR1C1 aldo-keto reductase family 1, member C1
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
ARSD arylsulfatase D
ASB4 ankyrin repeat and SOCS box containing 4
ASIC4 acid sensing (proton gated) ion channel family member 4
B3GAT1 beta-1,3-glucuronyltransferase 1
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CAMK4 calcium/calmodulin-dependent protein kinase IV
CCDC28B coiled-coil domain containing 28B
CCL19 chemokine (C-C motif) ligand 19
CD5L CD5 molecule-like
CD70 CD70 molecule
CD79A CD79a molecule, immunoglobulin-associated alpha
CES3 carboxylesterase 3
CFAP45 cilia and flagella associated protein 45
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CIZ1 CDKN1A interacting zinc finger protein 1
COL3A1 collagen, type III, alpha 1
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8
DCBLD2 discoidin, CUB and LCCL domain containing 2
DGCR14 DiGeorge syndrome critical region gene 14
DGCR8 DGCR8 microprocessor complex subunit
DLGAP1 discs, large (Drosophila) homolog-associated protein 1
DMPK dystrophia myotonica-protein kinase
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DUSP9 dual specificity phosphatase 9
EFS embryonal Fyn-associated substrate
EMID1 EMI domain containing 1
ERO1LB ERO1-like beta (S. cerevisiae)
EZR ezrin
FGF1 fibroblast growth factor 1 (acidic)
FGF16 fibroblast growth factor 16
FLJ21369 uncharacterized protein FLJ21369
FSCN3 fascin actin-bundling protein 3, testicular
GABRQ gamma-aminobutyric acid (GABA) A receptor, theta
GABRR1 gamma-aminobutyric acid (GABA) A receptor, rho 1
GSTTP1 glutathione S-transferase theta pseudogene 1
HFE hemochromatosis
HLF hepatic leukemia factor
HOXA10 homeobox A10
HPR haptoglobin-related protein
HR hair growth associated
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
IGFALS insulin-like growth factor binding protein, acid labile subunit
KCNH6 potassium channel, voltage gated eag related subfamily H, member 6
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KRT83 keratin 83, type II
L3MBTL1 l(3)mbt-like 1 (Drosophila)
LIMCH1 LIM and calponin homology domains 1
LY6G6C lymphocyte antigen 6 complex, locus G6C
MAOB monoamine oxidase B
MEF2C myocyte enhancer factor 2C
MEGF6 multiple EGF-like-domains 6
MOB3B MOB kinase activator 3B
MXD4 MAX dimerization protein 4
MYL4 myosin, light chain 4, alkali; atrial, embryonic
MYO1A myosin IA
NCOR2 nuclear receptor corepressor 2
NOX5 NADPH oxidase, EF-hand calcium binding domain 5
OR2W1 olfactory receptor, family 2, subfamily W, member 1
PAX2 paired box 2
PCDHGC3 protocadherin gamma subfamily C, 3
PEG10 paternally expressed 10
POU2F2 POU class 2 homeobox 2
PRB1 proline-rich protein BstNI subfamily 1
PRUNE2 prune homolog 2 (Drosophila)
PVR poliovirus receptor
PYY peptide YY
RAB33A RAB33A, member RAS oncogene family
RGS12 regulator of G-protein signaling 12
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
SIGLEC7 sialic acid binding Ig-like lectin 7
SIGLEC8 sialic acid binding Ig-like lectin 8
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SNCAIP synuclein, alpha interacting protein
SP140 SP140 nuclear body protein
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STATH statherin
SYN3 synapsin III
TAF6L TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TAPBP TAP binding protein (tapasin)
TGM2 transglutaminase 2
TIMP3 TIMP metallopeptidase inhibitor 3
TJAP1 tight junction associated protein 1 (peripheral)
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
TPPP tubulin polymerization promoting protein
TRH thyrotropin-releasing hormone
TRPC2 transient receptor potential cation channel, subfamily C, member 2, pseudogene
TUBA8 tubulin, alpha 8
TYRO3 TYRO3 protein tyrosine kinase
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VIM vimentin
ZNF345 zinc finger protein 345
ZNF44 zinc finger protein 44

decreased expression

Symbol Name
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ADAM15 ADAM metallopeptidase domain 15
ADM adrenomedullin
ADTRP androgen-dependent TFPI-regulating protein
ALOX15 arachidonate 15-lipoxygenase
AOC2 amine oxidase, copper containing 2 (retina-specific)
BAGE B melanoma antigen
BCAS1 breast carcinoma amplified sequence 1
BMP4 bone morphogenetic protein 4
C11ORF30 chromosome 11 open reading frame 30
C5ORF45 chromosome 5 open reading frame 45
CAMK1 calcium/calmodulin-dependent protein kinase I
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCDC9 coiled-coil domain containing 9
CCNL2 cyclin L2
CCNO cyclin O
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CHKB choline kinase beta
CHRM3 cholinergic receptor, muscarinic 3
CHST10 carbohydrate sulfotransferase 10
CLCN6 chloride channel, voltage-sensitive 6
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
CNTFR ciliary neurotrophic factor receptor
COPZ2 coatomer protein complex, subunit zeta 2
CRABP1 cellular retinoic acid binding protein 1
CRMP1 collapsin response mediator protein 1
CXADR coxsackie virus and adenovirus receptor
DGKE diacylglycerol kinase, epsilon 64kDa
EHMT1 euchromatic histone-lysine N-methyltransferase 1
ENO3 enolase 3 (beta, muscle)
EPB41L5 erythrocyte membrane protein band 4.1 like 5
FAM76A family with sequence similarity 76, member A
FBXL6 F-box and leucine-rich repeat protein 6
FLT4 fms-related tyrosine kinase 4
FOXN2 forkhead box N2
GADD45G growth arrest and DNA-damage-inducible, gamma
GLCE glucuronic acid epimerase
GSTCD glutathione S-transferase, C-terminal domain containing
HDAC5 histone deacetylase 5
HOXC5 homeobox C5
HSPA1L heat shock 70kDa protein 1-like
IMPACT impact RWD domain protein
KCNK12 potassium channel, two pore domain subfamily K, member 12
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KIF13B kinesin family member 13B
KLK5 kallikrein-related peptidase 5
LMX1B LIM homeobox transcription factor 1, beta
LOC390998 ribosomal protein L10 pseudogene
LTBP2 latent transforming growth factor beta binding protein 2
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MAST3 microtubule associated serine/threonine kinase 3
MMP9 matrix metallopeptidase 9
NDOR1 NADPH dependent diflavin oxidoreductase 1
NEUROD4 neuronal differentiation 4
NT5DC3 5'-nucleotidase domain containing 3
P2RY4 pyrimidinergic receptor P2Y, G-protein coupled, 4
PARD6A par-6 family cell polarity regulator alpha
PCDHA6 protocadherin alpha 6
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PMP22 peripheral myelin protein 22
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PQLC2 PQ loop repeat containing 2
PRR4 proline rich 4 (lacrimal)
RETSAT retinol saturase (all-trans-retinol 13,14-reductase)
RPGR retinitis pigmentosa GTPase regulator
SCN10A sodium channel, voltage gated, type X alpha subunit
SCUBE2 signal peptide, CUB domain, EGF-like 2
SEC14L2 SEC14-like 2 (S. cerevisiae)
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
SLC17A2 solute carrier family 17, member 2
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLIT2 slit homolog 2 (Drosophila)
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
STIM1 stromal interaction molecule 1
SYCP2 synaptonemal complex protein 2
TEP1 telomerase-associated protein 1
TMCC2 transmembrane and coiled-coil domain family 2
TOR4A torsin family 4, member A
TRAIP TRAF interacting protein
TRDMT1 tRNA aspartic acid methyltransferase 1
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TSNAXIP1 translin-associated factor X interacting protein 1
TUBA3C tubulin, alpha 3c
UPK3B uroplakin 3B
USB1 U6 snRNA biogenesis 1
VPS9D1 VPS9 domain containing 1
YY2 YY2 transcription factor
ZFHX4 zinc finger homeobox 4
ZMAT5 zinc finger, matrin-type 5
ZNF180 zinc finger protein 180
ZNF35 zinc finger protein 35
ZNF442 zinc finger protein 442
ZNF573 zinc finger protein 573
ZNF747 zinc finger protein 747
ZSCAN31 zinc finger and SCAN domain containing 31