Prestwick-675-3682 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the Prestwick-675-3682 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ABAT 4-aminobutyrate aminotransferase
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACE angiotensin I converting enzyme
ACOT11 acyl-CoA thioesterase 11
ACOX3 acyl-CoA oxidase 3, pristanoyl
ACPP acid phosphatase, prostate
ADRBK1 adrenergic, beta, receptor kinase 1
ANKRD55 ankyrin repeat domain 55
APOL6 apolipoprotein L, 6
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BMP5 bone morphogenetic protein 5
BTF3P11 basic transcription factor 3 pseudogene 11
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CD93 CD93 molecule
CHN2 chimerin 2
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)
COL3A1 collagen, type III, alpha 1
CTNS cystinosin, lysosomal cystine transporter
CYBRD1 cytochrome b reductase 1
DMD dystrophin
DOCK10 dedicator of cytokinesis 10
ECE1 endothelin converting enzyme 1
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
EVI2A ecotropic viral integration site 2A
F13A1 coagulation factor XIII, A1 polypeptide
FAS Fas cell surface death receptor
FAXDC2 fatty acid hydroxylase domain containing 2
FLT3LG fms-related tyrosine kinase 3 ligand
FMO5 flavin containing monooxygenase 5
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GAS2 growth arrest-specific 2
GATA2 GATA binding protein 2
GGT1 gamma-glutamyltransferase 1
GPR137 G protein-coupled receptor 137
GRM7 glutamate receptor, metabotropic 7
HLA-DOA major histocompatibility complex, class II, DO alpha
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HOXB7 homeobox B7
HR hair growth associated
HRASLS2 HRAS-like suppressor 2
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
IL13 interleukin 13
INHA inhibin, alpha
INSL4 insulin-like 4 (placenta)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
JAK3 Janus kinase 3
KAT8 K(lysine) acetyltransferase 8
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KCTD14 potassium channel tetramerization domain containing 14
LDB2 LIM domain binding 2
LTA lymphotoxin alpha
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2
MARK1 MAP/microtubule affinity-regulating kinase 1
MATN1 matrilin 1, cartilage matrix protein
MEGF6 multiple EGF-like-domains 6
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MTRF1L mitochondrial translational release factor 1-like
MUC3B mucin 3B, cell surface associated
MYRF myelin regulatory factor
N4BP1 NEDD4 binding protein 1
NDRG2 NDRG family member 2
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NPFF neuropeptide FF-amide peptide precursor
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin)
NRXN3 neurexin 3
PAPOLG poly(A) polymerase gamma
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PAX5 paired box 5
PDLIM4 PDZ and LIM domain 4
PDPN podoplanin
PER2 period circadian clock 2
PGAP3 post-GPI attachment to proteins 3
PGLYRP4 peptidoglycan recognition protein 4
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLA2G1B phospholipase A2, group IB (pancreas)
PLEKHS1 pleckstrin homology domain containing, family S member 1
POU3F4 POU class 3 homeobox 4
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C)
RAB6A RAB6A, member RAS oncogene family
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RNPS1 RNA binding protein S1, serine-rich domain
SAMD4A sterile alpha motif domain containing 4A
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SPANXC SPANX family, member C
TBC1D30 TBC1 domain family, member 30
TESC tescalcin
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TNNT2 troponin T type 2 (cardiac)
ZNF222 zinc finger protein 222
ZNF235 zinc finger protein 235

decreased expression

Symbol Name
ADCY6 adenylate cyclase 6
ADGRL2 adhesion G protein-coupled receptor L2
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4
BCL9 B-cell CLL/lymphoma 9
BEGAIN brain-enriched guanylate kinase-associated
BTBD18 BTB (POZ) domain containing 18
C19ORF40 chromosome 19 open reading frame 40
C3 complement component 3
C5ORF42 chromosome 5 open reading frame 42
C9ORF9 chromosome 9 open reading frame 9
CBX8 chromobox homolog 8
CDHR2 cadherin-related family member 2
CDK20 cyclin-dependent kinase 20
CDON cell adhesion associated, oncogene regulated
CEL carboxyl ester lipase
CEP41 centrosomal protein 41kDa
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal)
CLSPN claspin
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
COL16A1 collagen, type XVI, alpha 1
COLGALT2 collagen beta(1-O)galactosyltransferase 2
CPED1 cadherin-like and PC-esterase domain containing 1
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DNMBP dynamin binding protein
FLCN folliculin
GALT galactose-1-phosphate uridylyltransferase
GBP2 guanylate binding protein 2, interferon-inducible
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GLB1L galactosidase, beta 1-like
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPR137B G protein-coupled receptor 137B
GPR19 G protein-coupled receptor 19
GREB1L growth regulation by estrogen in breast cancer-like
HDAC11 histone deacetylase 11
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HOXA2 homeobox A2
HSF2BP heat shock transcription factor 2 binding protein
IFI6 interferon, alpha-inducible protein 6
IFNA17 interferon, alpha 17
IQCC IQ motif containing C
KRT17 keratin 17, type I
KRT8P12 keratin 8 pseudogene 12
KRT9 keratin 9, type I
LAX1 lymphocyte transmembrane adaptor 1
LIMS2 LIM and senescent cell antigen-like domains 2
LIN7B lin-7 homolog B (C. elegans)
LMTK2 lemur tyrosine kinase 2
LPPR4 lipid phosphate phosphatase-related protein type 4
MAK male germ cell-associated kinase
MCC mutated in colorectal cancers
MEFV Mediterranean fever
MEGF8 multiple EGF-like-domains 8
MMP3 matrix metallopeptidase 3
MTA2 metastasis associated 1 family, member 2
NIPAL2 NIPA-like domain containing 2
NPHP1 nephronophthisis 1 (juvenile)
NPY1R neuropeptide Y receptor Y1
NTSR1 neurotensin receptor 1 (high affinity)
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
PADI1 peptidyl arginine deiminase, type I
PCDH17 protocadherin 17
PCDHA9 protocadherin alpha 9
PENK proenkephalin
PGP phosphoglycolate phosphatase
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLEKHO1 pleckstrin homology domain containing, family O member 1
PNRC1 proline-rich nuclear receptor coactivator 1
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
REM1 RAS (RAD and GEM)-like GTP-binding 1
RFPL3 ret finger protein-like 3
RGCC regulator of cell cycle
RPL23AP32 ribosomal protein L23a pseudogene 32
SCN8A sodium channel, voltage gated, type VIII alpha subunit
SCUBE3 signal peptide, CUB domain, EGF-like 3
SETD8 SET domain containing (lysine methyltransferase) 8
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC35C2 solute carrier family 35 (GDP-fucose transporter), member C2
SLC46A3 solute carrier family 46, member 3
SLITRK5 SLIT and NTRK-like family, member 5
SLMO1 slowmo homolog 1 (Drosophila)
SLN sarcolipin
SP4 Sp4 transcription factor
STAG3 stromal antigen 3
STIM1 stromal interaction molecule 1
STK16 serine/threonine kinase 16
SYCE1L synaptonemal complex central element protein 1-like
TFCP2L1 transcription factor CP2-like 1
TICAM1 toll-like receptor adaptor molecule 1
TLR2 toll-like receptor 2
TPST2 tyrosylprotein sulfotransferase 2
TRAPPC6A trafficking protein particle complex 6A
UBQLN4 ubiquilin 4
VEGFB vascular endothelial growth factor B
VLDLR very low density lipoprotein receptor
ZBTB48 zinc finger and BTB domain containing 48
ZNF506 zinc finger protein 506
ZNF668 zinc finger protein 668