Prestwick-675-6042 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the Prestwick-675-6042 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AGFG1 ArfGAP with FG repeats 1
AMACR alpha-methylacyl-CoA racemase
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38
ARID3B AT rich interactive domain 3B (BRIGHT-like)
BET1L Bet1 golgi vesicular membrane trafficking protein-like
BIRC3 baculoviral IAP repeat containing 3
C19ORF66 chromosome 19 open reading frame 66
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CCDC64 coiled-coil domain containing 64
CCPG1 cell cycle progression 1
CD300A CD300a molecule
CD47 CD47 molecule
CD48 CD48 molecule
CD70 CD70 molecule
CEP295 centrosomal protein 295kDa
CFAP45 cilia and flagella associated protein 45
CFHR4 complement factor H-related 4
CNTNAP2 contactin associated protein-like 2
CREBBP CREB binding protein
CRYAB crystallin, alpha B
CTRL chymotrypsin-like
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
ELL2 elongation factor, RNA polymerase II, 2
ELP6 elongator acetyltransferase complex subunit 6
EMP1 epithelial membrane protein 1
ERC2-IT1 ERC2 intronic transcript 1
FAT4 FAT atypical cadherin 4
FBXO21 F-box protein 21
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GIPR gastric inhibitory polypeptide receptor
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GRAMD1C GRAM domain containing 1C
GRM3 glutamate receptor, metabotropic 3
GRM6 glutamate receptor, metabotropic 6
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
ICOSLG inducible T-cell co-stimulator ligand
ITGA7 integrin, alpha 7
ITGA8 integrin, alpha 8
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KIAA1467 KIAA1467
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLHL25 kelch-like family member 25
KLK7 kallikrein-related peptidase 7
KMT2A lysine (K)-specific methyltransferase 2A
KRT15 keratin 15, type I
KRTAP5-8 keratin associated protein 5-8
LAMP1 lysosomal-associated membrane protein 1
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
LIMK1 LIM domain kinase 1
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma
MBD2 methyl-CpG binding domain protein 2
MEF2D myocyte enhancer factor 2D
MFGE8 milk fat globule-EGF factor 8 protein
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
NCOR2 nuclear receptor corepressor 2
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
NSUN6 NOP2/Sun domain family, member 6
OR1G1 olfactory receptor, family 1, subfamily G, member 1
OR2W1 olfactory receptor, family 2, subfamily W, member 1
P3H2 prolyl 3-hydroxylase 2
PDE12 phosphodiesterase 12
PDE3A phosphodiesterase 3A, cGMP-inhibited
PMFBP1 polyamine modulated factor 1 binding protein 1
POLM polymerase (DNA directed), mu
POU2F2 POU class 2 homeobox 2
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PQBP1 polyglutamine binding protein 1
PRB4 proline-rich protein BstNI subfamily 4
PURA purine-rich element binding protein A
PVR poliovirus receptor
RGS12 regulator of G-protein signaling 12
RIMS3 regulating synaptic membrane exocytosis 3
RORC RAR-related orphan receptor C
RXRB retinoid X receptor, beta
SAMD9 sterile alpha motif domain containing 9
SCAMP1 secretory carrier membrane protein 1
SECTM1 secreted and transmembrane 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SIRT5 sirtuin 5
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SOX10 SRY (sex determining region Y)-box 10
STAC SH3 and cysteine rich domain
STK17A serine/threonine kinase 17a
SV2A synaptic vesicle glycoprotein 2A
SYN3 synapsin III
SYNDIG1 synapse differentiation inducing 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFPI2 tissue factor pathway inhibitor 2
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
TP63 tumor protein p63
TPM2 tropomyosin 2 (beta)
TTC38 tetratricopeptide repeat domain 38
VIM vimentin
WDR55 WD repeat domain 55
ZNF446 zinc finger protein 446

decreased expression

Symbol Name
ACAD10 acyl-CoA dehydrogenase family, member 10
ADCY7 adenylate cyclase 7
ADGRG2 adhesion G protein-coupled receptor G2
ANP32A-IT1 ANP32A intronic transcript 1
AOC2 amine oxidase, copper containing 2 (retina-specific)
ASPHD1 aspartate beta-hydroxylase domain containing 1
ATG10 autophagy related 10
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
B9D2 B9 protein domain 2
BAG4 BCL2-associated athanogene 4
BAHD1 bromo adjacent homology domain containing 1
BMP15 bone morphogenetic protein 15
C14ORF93 chromosome 14 open reading frame 93
C1QB complement component 1, q subcomponent, B chain
C22ORF46 chromosome 22 open reading frame 46
CCDC25 coiled-coil domain containing 25
CCDC85C coiled-coil domain containing 85C
CCDC88C coiled-coil domain containing 88C
CDADC1 cytidine and dCMP deaminase domain containing 1
CEACAM4 carcinoembryonic antigen-related cell adhesion molecule 4
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLDN17 claudin 17
CLIP4 CAP-GLY domain containing linker protein family, member 4
CNGB3 cyclic nucleotide gated channel beta 3
CRY2 cryptochrome circadian clock 2
CRYBB2P1 crystallin, beta B2 pseudogene 1
CRYGC crystallin, gamma C
CUL9 cullin 9
CUZD1 CUB and zona pellucida-like domains 1
DBF4B DBF4 zinc finger B
DDIT3 DNA-damage-inducible transcript 3
DES desmin
DMXL1 Dmx-like 1
DYSF dysferlin
ENO3 enolase 3 (beta, muscle)
ERN2 endoplasmic reticulum to nucleus signaling 2
EXO5 exonuclease 5
FAM131A family with sequence similarity 131, member A
FAM169A family with sequence similarity 169, member A
FGL1 fibrinogen-like 1
FMOD fibromodulin
FOXC1 forkhead box C1
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GAMT guanidinoacetate N-methyltransferase
GPC3 glypican 3
HDAC5 histone deacetylase 5
HIST1H2AJ histone cluster 1, H2aj
IFI35 interferon-induced protein 35
INO80D INO80 complex subunit D
INPP5J inositol polyphosphate-5-phosphatase J
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KCNK12 potassium channel, two pore domain subfamily K, member 12
KDM8 lysine (K)-specific demethylase 8
KPNA5 karyopherin alpha 5 (importin alpha 6)
LIME1 Lck interacting transmembrane adaptor 1
LMX1B LIM homeobox transcription factor 1, beta
LPXN leupaxin
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MMP3 matrix metallopeptidase 3
MSI1 musashi RNA-binding protein 1
NDE1 nudE neurodevelopment protein 1
NNAT neuronatin
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
OLFML2A olfactomedin-like 2A
OSGIN1 oxidative stress induced growth inhibitor 1
PER3 period circadian clock 3
PHEX phosphate regulating endopeptidase homolog, X-linked
PHOX2A paired-like homeobox 2a
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PROS1 protein S (alpha)
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2
PRSS16 protease, serine, 16 (thymus)
PRSS53 protease, serine, 53
RAB30 RAB30, member RAS oncogene family
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RGCC regulator of cell cycle
RNF122 ring finger protein 122
SDC3 syndecan 3
SIGLEC15 sialic acid binding Ig-like lectin 15
STAG3 stromal antigen 3
STRA6 stimulated by retinoic acid 6
SYNC syncoilin, intermediate filament protein
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TCTN2 tectonic family member 2
THBS3 thrombospondin 3
TNS2 tensin 2
TUBA3C tubulin, alpha 3c
USP27X ubiquitin specific peptidase 27, X-linked
VEGFB vascular endothelial growth factor B
VPS9D1 VPS9 domain containing 1
YY2 YY2 transcription factor
ZNF10 zinc finger protein 10
ZNF134 zinc finger protein 134
ZNF362 zinc finger protein 362
ZNF507 zinc finger protein 507
ZNF701 zinc finger protein 701