Prestwick-682-2164 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the Prestwick-682-2164 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACOX1 acyl-CoA oxidase 1, palmitoyl
AGGF1 angiogenic factor with G patch and FHA domains 1
AMBRA1 autophagy/beclin-1 regulator 1
APLP2 amyloid beta (A4) precursor-like protein 2
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide
C2CD2L C2CD2-like
C3ORF18 chromosome 3 open reading frame 18
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CFAP45 cilia and flagella associated protein 45
CLGN calmegin
CLIC5 chloride intracellular channel 5
CNOT4 CCR4-NOT transcription complex, subunit 4
CPNE7 copine VII
CRABP2 cellular retinoic acid binding protein 2
CREM cAMP responsive element modulator
CRY2 cryptochrome circadian clock 2
CYR61 cysteine-rich, angiogenic inducer, 61
DDAH2 dimethylarginine dimethylaminohydrolase 2
DDR1-AS1 DDR1 antisense RNA 1 (head to head)
DHRS7 dehydrogenase/reductase (SDR family) member 7
DMWD dystrophia myotonica, WD repeat containing
DTNA dystrobrevin, alpha
DUSP4 dual specificity phosphatase 4
EFNA4 ephrin-A4
EFR3B EFR3 homolog B (S. cerevisiae)
EIF1 eukaryotic translation initiation factor 1
ELAC1 elaC ribonuclease Z 1
EML2 echinoderm microtubule associated protein like 2
EXOC7 exocyst complex component 7
EXOSC2 exosome component 2
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit
FAM168A family with sequence similarity 168, member A
FLOT1 flotillin 1
FLRT1 fibronectin leucine rich transmembrane protein 1
FOSL2 FOS-like antigen 2
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GRIK5 glutamate receptor, ionotropic, kainate 5
GSTTP1 glutathione S-transferase theta pseudogene 1
GTPBP3 GTP binding protein 3 (mitochondrial)
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
HFE hemochromatosis
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IL5RA interleukin 5 receptor, alpha
IQCK IQ motif containing K
KAT2A K(lysine) acetyltransferase 2A
KRAS Kirsten rat sarcoma viral oncogene homolog
KRIT1 KRIT1, ankyrin repeat containing
LENEP lens epithelial protein
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LMAN1 lectin, mannose-binding, 1
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAP4 microtubule-associated protein 4
MARC1 mitochondrial amidoxime reducing component 1
MBNL1 muscleblind-like splicing regulator 1
MBNL2 muscleblind-like splicing regulator 2
MED25 mediator complex subunit 25
MFAP3 microfibrillar-associated protein 3
MLN motilin
MOXD1 monooxygenase, DBH-like 1
N4BP2L2-IT2 N4BPL2 intronic transcript 2
NBPF10 neuroblastoma breakpoint family, member 10
NEK9 NIMA-related kinase 9
NIPAL2 NIPA-like domain containing 2
NPAS3 neuronal PAS domain protein 3
NPC1 Niemann-Pick disease, type C1
NR2F1 nuclear receptor subfamily 2, group F, member 1
NUCB1 nucleobindin 1
NUMA1 nuclear mitotic apparatus protein 1
OR2H2 olfactory receptor, family 2, subfamily H, member 2
ORAI2 ORAI calcium release-activated calcium modulator 2
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PPP2R4 protein phosphatase 2A activator, regulatory subunit 4
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
R3HDM1 R3H domain containing 1
RAD52 RAD52 homolog (S. cerevisiae)
REC8 REC8 meiotic recombination protein
SGK2 serum/glucocorticoid regulated kinase 2
SIL1 SIL1 nucleotide exchange factor
SIPA1L3 signal-induced proliferation-associated 1 like 3
SIT1 signaling threshold regulating transmembrane adaptor 1
SLC16A4 solute carrier family 16, member 4
SLMO1 slowmo homolog 1 (Drosophila)
SOCS6 suppressor of cytokine signaling 6
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SRF serum response factor (c-fos serum response element-binding transcription factor)
STS steroid sulfatase (microsomal), isozyme S
TAF6L TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TAPT1 transmembrane anterior posterior transformation 1
TSC22D3 TSC22 domain family, member 3
UBE2I ubiquitin-conjugating enzyme E2I
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
ZBTB20 zinc finger and BTB domain containing 20
ZMAT5 zinc finger, matrin-type 5
ZNF510 zinc finger protein 510
ZNF696 zinc finger protein 696

decreased expression

Symbol Name
A1CF APOBEC1 complementation factor
ACOX2 acyl-CoA oxidase 2, branched chain
ASTE1 asteroid homolog 1 (Drosophila)
ATAT1 alpha tubulin acetyltransferase 1
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
C16ORF45 chromosome 16 open reading frame 45
C2ORF27A chromosome 2 open reading frame 27A
C6ORF47 chromosome 6 open reading frame 47
CA11 carbonic anhydrase XI
CAPN5 calpain 5
CD34 CD34 molecule
CDA cytidine deaminase
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CIDEC cell death-inducing DFFA-like effector c
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DGKG diacylglycerol kinase, gamma 90kDa
DOC2A double C2-like domains, alpha
EMILIN2 elastin microfibril interfacer 2
EPHA4 EPH receptor A4
EPHB6 EPH receptor B6
EXOSC1 exosome component 1
F5 coagulation factor V (proaccelerin, labile factor)
FAM204A family with sequence similarity 204, member A
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FKBP5 FK506 binding protein 5
FMOD fibromodulin
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GJA1 gap junction protein, alpha 1, 43kDa
GLI3 GLI family zinc finger 3
GSTA3 glutathione S-transferase alpha 3
GSTT1 glutathione S-transferase theta 1
HAAO 3-hydroxyanthranilate 3,4-dioxygenase
HDAC7 histone deacetylase 7
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HSPA1L heat shock 70kDa protein 1-like
HYAL2 hyaluronoglucosaminidase 2
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
KCNMB4 potassium channel subfamily M regulatory beta subunit 4
KIAA0355 KIAA0355
KIF20A kinesin family member 20A
LATS1 large tumor suppressor kinase 1
LHFPL2 lipoma HMGIC fusion partner-like 2
LIMD2 LIM domain containing 2
LIME1 Lck interacting transmembrane adaptor 1
LRP3 low density lipoprotein receptor-related protein 3
LRP5 low density lipoprotein receptor-related protein 5
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAPKBP1 mitogen-activated protein kinase binding protein 1
MEGF8 multiple EGF-like-domains 8
MRPS18C mitochondrial ribosomal protein S18C
NECAB3 N-terminal EF-hand calcium binding protein 3
NOD2 nucleotide-binding oligomerization domain containing 2
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PDLIM2 PDZ and LIM domain 2 (mystique)
PIPOX pipecolic acid oxidase
PLD2 phospholipase D2
PODNL1 podocan-like 1
PRSS12 protease, serine, 12 (neurotrypsin, motopsin)
RABL6 RAB, member RAS oncogene family-like 6
RETN resistin
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RNF39 ring finger protein 39
RPL13P5 ribosomal protein L13 pseudogene 5
SCAMP4 secretory carrier membrane protein 4
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SOCS7 suppressor of cytokine signaling 7
SOX12 SRY (sex determining region Y)-box 12
SPATA1 spermatogenesis associated 1
SPINT1 serine peptidase inhibitor, Kunitz type 1
STARD3 StAR-related lipid transfer (START) domain containing 3
STEAP1 six transmembrane epithelial antigen of the prostate 1
STIM1 stromal interaction molecule 1
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TEC tec protein tyrosine kinase
TFF2 trefoil factor 2
THRAP3 thyroid hormone receptor associated protein 3
TIMP2 TIMP metallopeptidase inhibitor 2
TLR8 toll-like receptor 8
TPM3 tropomyosin 3
TRAF2 TNF receptor-associated factor 2
TREM2 triggering receptor expressed on myeloid cells 2
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TTC30A tetratricopeptide repeat domain 30A
TUBA4B tubulin, alpha 4b
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene)
WASF3 WAS protein family, member 3
WDR4 WD repeat domain 4
ZFHX2 zinc finger homeobox 2
ZIM2 zinc finger, imprinted 2
ZNF345 zinc finger protein 345
ZSCAN31 zinc finger and SCAN domain containing 31