Prestwick-685-7382 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the Prestwick-685-7382 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
AMDHD2 amidohydrolase domain containing 2
AMT aminomethyltransferase
ANKRD6 ankyrin repeat domain 6
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ATP9A ATPase, class II, type 9A
C14ORF105 chromosome 14 open reading frame 105
CACNB3 calcium channel, voltage-dependent, beta 3 subunit
CADM3 cell adhesion molecule 3
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CD6 CD6 molecule
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3
CEP162 centrosomal protein 162kDa
CES2 carboxylesterase 2
CHRM3 cholinergic receptor, muscarinic 3
CIR1 corepressor interacting with RBPJ, 1
COL8A1 collagen, type VIII, alpha 1
DCTN1 dynactin 1
DDR1-AS1 DDR1 antisense RNA 1 (head to head)
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DMBT1 deleted in malignant brain tumors 1
DPYS dihydropyrimidinase
DUSP1 dual specificity phosphatase 1
ELOVL5 ELOVL fatty acid elongase 5
EPHB2 EPH receptor B2
ETV1 ets variant 1
FKBP8 FK506 binding protein 8, 38kDa
FRMD4B FERM domain containing 4B
FUZ fuzzy planar cell polarity protein
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GAS7 growth arrest-specific 7
GATA2 GATA binding protein 2
GLRX3 glutaredoxin 3
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GRK5 G protein-coupled receptor kinase 5
HN1L hematological and neurological expressed 1-like
ICA1 islet cell autoantigen 1, 69kDa
INSIG1 insulin induced gene 1
KIF1C kinesin family member 1C
KLHL4 kelch-like family member 4
LDAH lipid droplet associated hydrolase
LDLR low density lipoprotein receptor
LOC100286895 cell division cycle 27 homolog pseudogene
LOXL2 lysyl oxidase-like 2
LRRC23 leucine rich repeat containing 23
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MCM3AP minichromosome maintenance complex component 3 associated protein
MED31 mediator complex subunit 31
MFAP3L microfibrillar-associated protein 3-like
MFSD11 major facilitator superfamily domain containing 11
MX1 MX dynamin-like GTPase 1
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
N4BP1 NEDD4 binding protein 1
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NUP214 nucleoporin 214kDa
PDCD6 programmed cell death 6
PDE4DIP phosphodiesterase 4D interacting protein
PDE8B phosphodiesterase 8B
PEX6 peroxisomal biogenesis factor 6
PHLDB1 pleckstrin homology-like domain, family B, member 1
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PLK4 polo-like kinase 4
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PTPRH protein tyrosine phosphatase, receptor type, H
R3HCC1L R3H domain and coiled-coil containing 1-like
RARG retinoic acid receptor, gamma
RBMS2 RNA binding motif, single stranded interacting protein 2
RPL23AP32 ribosomal protein L23a pseudogene 32
RPL37A ribosomal protein L37a
RPL7 ribosomal protein L7
RPLP2 ribosomal protein, large, P2
RUNX3 runt-related transcription factor 3
RUSC2 RUN and SH3 domain containing 2
SETDB1 SET domain, bifurcated 1
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SIRAL2 SIR2 antiphage like 2
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SND1-IT1 SND1 intronic transcript 1
SNPH syntaphilin
SP100 SP100 nuclear antigen
SPI1 Spi-1 proto-oncogene
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3
SPTAN1 spectrin, alpha, non-erythrocytic 1
TAGLN3 transgelin 3
TAOK2 TAO kinase 2
TBL1Y transducin (beta)-like 1, Y-linked
TMEM63A transmembrane protein 63A
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TRPC1 transient receptor potential cation channel, subfamily C, member 1
UBQLN4 ubiquilin 4
WDR25 WD repeat domain 25
ZNF277 zinc finger protein 277
ZNF442 zinc finger protein 442
ZNF76 zinc finger protein 76
ZXDB zinc finger, X-linked, duplicated B

decreased expression

Symbol Name
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
ACAD8 acyl-CoA dehydrogenase family, member 8
ACKR3 atypical chemokine receptor 3
ADGRF1 adhesion G protein-coupled receptor F1
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
ALS2CL ALS2 C-terminal like
AMOTL2 angiomotin like 2
ANKEF1 ankyrin repeat and EF-hand domain containing 1
ANOS1 anosmin 1
APH1B APH1B gamma secretase subunit
ASB13 ankyrin repeat and SOCS box containing 13
AUH AU RNA binding protein/enoyl-CoA hydratase
BAG4 BCL2-associated athanogene 4
BDNF brain-derived neurotrophic factor
BEX1 brain expressed, X-linked 1
C16ORF59 chromosome 16 open reading frame 59
C3ORF52 chromosome 3 open reading frame 52
CBX7 chromobox homolog 7
CCNT1 cyclin T1
CDH7 cadherin 7, type 2
CDK3 cyclin-dependent kinase 3
CENPJ centromere protein J
CLEC16A C-type lectin domain family 16, member A
CPEB1 cytoplasmic polyadenylation element binding protein 1
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
ECM1 extracellular matrix protein 1
ELOVL4 ELOVL fatty acid elongase 4
EN2 engrailed homeobox 2
EPHB6 EPH receptor B6
EVPL envoplakin
F8 coagulation factor VIII, procoagulant component
FADS2 fatty acid desaturase 2
FAM188A family with sequence similarity 188, member A
FCHSD2 FCH and double SH3 domains 2
FHOD1 formin homology 2 domain containing 1
FOXC1 forkhead box C1
GAB2 GRB2-associated binding protein 2
GAMT guanidinoacetate N-methyltransferase
GATAD2A GATA zinc finger domain containing 2A
GLDC glycine dehydrogenase (decarboxylating)
GPATCH3 G patch domain containing 3
INF2 inverted formin, FH2 and WH2 domain containing
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
KCTD7 potassium channel tetramerization domain containing 7
KIRREL kin of IRRE like (Drosophila)
LINS lines homolog (Drosophila)
MED22 mediator complex subunit 22
METTL1 methyltransferase like 1
METTL2B methyltransferase like 2B
MNX1 motor neuron and pancreas homeobox 1
MOB3B MOB kinase activator 3B
MORC3 MORC family CW-type zinc finger 3
MOXD1 monooxygenase, DBH-like 1
MST1R macrophage stimulating 1 receptor
MTMR11 myotubularin related protein 11
MYL5 myosin, light chain 5, regulatory
NABP2 nucleic acid binding protein 2
NMNAT2 nicotinamide nucleotide adenylyltransferase 2
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PEX26 peroxisomal biogenesis factor 26
PHKB phosphorylase kinase, beta
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLA2G15 phospholipase A2, group XV
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
POLDIP2 polymerase (DNA-directed), delta interacting protein 2
RAD54L2 RAD54-like 2 (S. cerevisiae)
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RBM38 RNA binding motif protein 38
RPP25 ribonuclease P/MRP 25kDa subunit
SCARA3 scavenger receptor class A, member 3
SERINC5 serine incorporator 5
SETBP1 SET binding protein 1
SETD1B SET domain containing 1B
SH3GLB2 SH3-domain GRB2-like endophilin B2
SIDT1 SID1 transmembrane family, member 1
SIGLEC15 sialic acid binding Ig-like lectin 15
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
STAC SH3 and cysteine rich domain
STK16 serine/threonine kinase 16
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae)
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
SYNPO synaptopodin
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TMEM132A transmembrane protein 132A
TMEM62 transmembrane protein 62
TMEM8A transmembrane protein 8A
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TRAPPC11 trafficking protein particle complex 11
UGT8 UDP glycosyltransferase 8
ZBTB39 zinc finger and BTB domain containing 39
ZC3H3 zinc finger CCCH-type containing 3
ZKSCAN4 zinc finger with KRAB and SCAN domains 4
ZNF189 zinc finger protein 189
ZNF282 zinc finger protein 282
ZNF408 zinc finger protein 408
ZSCAN31 zinc finger and SCAN domain containing 31